| SUVRETTA CAPITAL MANAGEMENT, LLC | 10,286,937 | $116,140 |
| STIFEL FINANCIAL CORP | 9,939,856 | $112,221 |
| BlackRock, Inc. | 9,448,040 | $106,668 |
| INFINITUM ASSET MANAGEMENT, LLC | 6,250,000 | $70,563 |
| STATE STREET CORP | 5,716,487 | $64,539 |
| TCG Crossover Management, LLC | 4,631,317 | $52,288 |
| VANGUARD GROUP INC | 4,395,946 | $49,630 |
| D. E. Shaw & Co., Inc. | 2,694,234 | $30,418 |
| FMR LLC | 2,682,234 | $30,282 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,392,277 | $27,014 |
| BNP PARIBAS ARBITRAGE, SA | 2,093,816 | $23,639 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,018,550 | $23 |
| GOLDMAN SACHS GROUP INC | 1,962,206 | $22,153 |
| BANK OF AMERICA CORP /DE/ | 1,792,443 | $20,237 |
| CITADEL ADVISORS LLC | 1,743,993 | $19,690 |
| Schonfeld Strategic Advisors LLC | 1,606,777 | $18,141 |
| BALYASNY ASSET MANAGEMENT L.P. | 1,591,054 | $17,963 |
| Qube Research & Technologies Ltd | 1,570,610 | $17,732 |
| Integral Health Asset Management, LLC | 1,500,000 | $16,935 |
| AQR CAPITAL MANAGEMENT LLC | 1,460,108 | $16,485 |
| JANUS HENDERSON GROUP PLC | 1,407,365 | $15,895 |
| Capital Research Global Investors | 1,332,792 | $15,047 |
| MILLENNIUM MANAGEMENT LLC | 1,324,247 | $14,951 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,318,775 | $14,889 |
| TWO SIGMA INVESTMENTS, LP | 1,259,031 | $14,214 |
| MYDA Advisors LLC | 1,250,000 | $14,113 |
| Sio Capital Management, LLC | 1,244,764 | $14,053 |
| ARS Investment Partners, LLC | 1,239,600 | $13,995 |
| ExodusPoint Capital Management, LP | 1,192,026 | $13,458 |
| UBS Group AG | 1,188,358 | $13,417 |
| MORGAN STANLEY | 975,196 | $11,010 |
| Iron Triangle Partners LP | 958,336 | $10,820 |
| Simplify Asset Management Inc. | 958,202 | $10,818 |
| DAFNA Capital Management LLC | 955,235 | $10,785 |
| Walleye Capital LLC | 854,424 | $9,646 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 847,412 | $9,567 |
| NORTHERN TRUST CORP | 840,285 | $9,487 |
| JANE STREET GROUP, LLC | 839,517 | $9,478 |
| ORACLE INVESTMENT MANAGEMENT INC | 772,181 | $8,718 |
| 5AM Venture Management, LLC | 738,972 | $8,343 |
| Nuveen, LLC | 731,953 | $8,264 |
| Fiera Capital Corp | 724,551 | $8,180 |
| Kynam Capital Management, LP | 702,884 | $7,936 |
| abrdn plc | 693,452 | $7,829 |
| Erste Asset Management GmbH | 693,300 | $7,851 |
| AMERICAN CENTURY COMPANIES INC | 685,584 | $7,740 |
| HRT FINANCIAL LP | 669,136 | $8 |
| Anson Funds Management LP | 667,381 | $7,535 |
| READYSTATE ASSET MANAGEMENT LP | 651,603 | $7,357 |
| Trexquant Investment LP | 604,182 | $6,821 |
| JPMORGAN CHASE & CO | 589,565 | $6,656 |
| UBS ASSET MANAGEMENT AMERICAS INC | 574,478 | $6,486 |
| Sarissa Capital Management LP | 513,184 | $5,794 |
| Pfizer Inc | 505,645 | $5,709 |
| Burkehill Global Management, LP | 500,000 | $5,645 |
| RAYMOND JAMES FINANCIAL INC | 436,796 | $4,931 |
| Point72 Asset Management, L.P. | 387,799 | $4,378 |
| TWO SIGMA ADVISERS, LP | 358,700 | $4,050 |
| QTR Family Wealth, LLC | 334,833 | $4,085 |
| BARCLAYS PLC | 320,846 | $3,622 |
| Woodline Partners LP | 300,389 | $3,391 |
| ALGERT GLOBAL LLC | 293,270 | $3 |
| Bank of New York Mellon Corp | 272,156 | $3,073 |
| Capital World Investors | 250,000 | $2,823 |
| Massar Capital Management, LP | 247,400 | $2,793 |
| NewEdge Wealth, LLC | 246,503 | $2,783 |
| Jump Financial, LLC | 245,891 | $2,776 |
| Swiss National Bank | 229,200 | $2,588 |
| Ikarian Capital, LLC | 212,481 | $2,399 |
| Quinn Opportunity Partners LLC | 210,326 | $2,375 |
| Rafferty Asset Management, LLC | 209,306 | $2,363 |
| Jain Global LLC | 208,987 | $2,359 |
| Invesco Ltd. | 194,751 | $2,199 |
| Voleon Capital Management LP | 174,035 | $1,965 |
| QVT Financial LP | 170,006 | $1,919 |
| IEQ CAPITAL, LLC | 163,388 | $1,845 |
| NEW YORK STATE COMMON RETIREMENT FUND | 160,251 | $1,809 |
| WELLS FARGO & COMPANY/MN | 151,516 | $1,711 |
| DCF Advisers, LLC | 151,500 | $1,710 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 150,000 | $1,694 |
| Graham Capital Management, L.P. | 145,852 | $1,647 |
| Eversept Partners, LP | 145,431 | $1,642 |
| Empowered Funds, LLC | 143,328 | $1,618 |
| TD Asset Management Inc | 141,678 | $1,600 |
| TANG CAPITAL MANAGEMENT LLC | 140,000 | $1,581 |
| DEUTSCHE BANK AG\ | 138,649 | $1,565 |
| VIRGINIA RETIREMENT SYSTEMS ET AL | 133,900 | $1,512 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 133,081 | $1,532 |
| ROYAL BANK OF CANADA | 122,581 | $1,384 |
| RHUMBLINE ADVISERS | 116,597 | $1,316 |
| Legal & General Group Plc | 113,426 | $1,281 |
| Aquatic Capital Management LLC | 111,838 | $1,263 |
| Susquehanna Portfolio Strategies, LLC | 110,840 | $1,251 |
| Knott David M Jr | 110,720 | $1,250 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 110,361 | $1,246 |
| SG Americas Securities, LLC | 105,518 | $1 |
| CAPITAL FUND MANAGEMENT S.A. | 104,574 | $1,181 |
| ALLIANCEBERNSTEIN L.P. | 96,236 | $1,087 |
| Ishara Investments LP | 88,000 | $994 |
| PDT Partners, LLC | 84,700 | $956 |
| 169 other institutions | 3,228,852 | $33,922 |