CRESCENT BIOPHARMA INC.

Ticker: CBIO CUSIP: G2545C104 Class: COM

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025
Shares 24,903 Value ($000) $289 Avg Close $12.74 Range $9.81 - $16.35
Q3 2025
Shares 24,923 Value ($000) $296 Avg Close $13.27 Range $10.83 - $17.39