| FMR LLC | 4,133,514 | $49,023 |
| BVF INC/IL | 2,748,763 | $32,600 |
| Fairmount Funds Management LLC | 2,747,866 | $32,590 |
| VR Adviser, LLC | 2,133,576 | $25,304 |
| FCPM III SERVICES B.V. | 1,677,852 | $19,899 |
| Vestal Point Capital, LP | 1,500,000 | $17,790 |
| Opaleye Management Inc. | 1,178,300 | $13,975 |
| TANG CAPITAL MANAGEMENT LLC | 872,398 | $10,347 |
| ADAR1 Capital Management, LLC | 606,000 | $7,187 |
| Logos Global Management LP | 600,000 | $7,116 |
| VANGUARD GROUP INC | 557,506 | $6,612 |
| PERCEPTIVE ADVISORS LLC | 453,686 | $5,381 |
| Deep Track Capital, LP | 453,686 | $5,381 |
| Boxer Capital Management, LLC | 453,686 | $5,381 |
| RTW INVESTMENTS, LP | 372,856 | $4,422 |
| NEXTBio Capital Management LP | 372,856 | $4,422 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 338,125 | $4 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 302,457 | $3,587 |
| Point72 Asset Management, L.P. | 300,000 | $3,558 |
| HEIGHTS CAPITAL MANAGEMENT, INC | 264,000 | $3,131 |
| Alyeska Investment Group, L.P. | 264,000 | $3,109 |
| WELLINGTON MANAGEMENT GROUP LLP | 143,412 | $1,627 |
| TWO SIGMA INVESTMENTS, LP | 125,224 | $1,485 |
| BALYASNY ASSET MANAGEMENT L.P. | 111,715 | $1,325 |
| BlackRock, Inc. | 109,230 | $1,295 |
| GEODE CAPITAL MANAGEMENT, LLC | 91,079 | $1,081 |
| Stonepine Capital Management, LLC | 87,682 | $1,040 |
| Blackstone Inc. | 75,614 | $897 |
| Burkehill Global Management, LP | 74,000 | $844 |
| Woodline Partners LP | 74,000 | $878 |
| Jefferies Financial Group Inc. | 64,244 | $762 |
| MILLENNIUM MANAGEMENT LLC | 61,882 | $734 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 57,048 | $677 |
| RENAISSANCE TECHNOLOGIES LLC | 46,700 | $554 |
| TWO SIGMA ADVISERS, LP | 32,500 | $385 |
| MORGAN STANLEY | 27,521 | $326 |
| STATE STREET CORP | 26,217 | $311 |
| GOLDMAN SACHS GROUP INC | 25,245 | $299 |
| MOORE CAPITAL MANAGEMENT, LP | 25,000 | $297 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 24,903 | $289 |
| JPMORGAN CHASE & CO | 23,339 | $277 |
| JANE STREET GROUP, LLC | 22,965 | $272 |
| MARSHALL WACE, LLP | 21,826 | $259 |
| NORTHERN TRUST CORP | 17,229 | $204 |
| HRT FINANCIAL LP | 13,083 | $0 |
| OMERS ADMINISTRATION Corp | 11,600 | $138 |
| UBS Group AG | 7,125 | $85 |
| BANK OF AMERICA CORP /DE/ | 5,573 | $66 |
| BNP PARIBAS ARBITRAGE, SA | 3,585 | $43 |
| CITIGROUP INC | 623 | $7 |
| Tower Research Capital LLC (TRC) | 409 | $5 |
| SBI Securities Co., Ltd. | 68 | $1 |
| Avion Wealth | 40 | $0 |
| OSAIC HOLDINGS, INC. | 26 | $0 |
| ROYAL BANK OF CANADA | 20 | $0 |
| GROUP ONE TRADING, L.P. | 4 | $0 |