CRESCENT BIOPHARMA INC.

Ticker: CBIO CUSIP: G2545C104 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025
Shares 125,224 Value ($000) $1,485 Avg Close $12.74 Range $9.81 - $16.35
Q3 2025
Shares 28,318 Value ($000) $337 Avg Close $13.27 Range $10.83 - $17.39