HORIZON PHARMA PLC

CUSIP: G4617B105 Class: SHS

ORBIMED ADVISORS LLC's Holding History (CIK: 0001055951)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 204,000 Value ($000) $4,043 Avg Close — Range —
Q2 2015
Shares 951,000 Value ($000) $33,038 Avg Close — Range —
Q1 2015
Shares 1,075,000 Value ($000) $27,918 Avg Close — Range —
Q4 2014
Shares 1,075,000 Value ($000) $13,857 Avg Close — Range —
Q3 2014
Shares 896,000 Value ($000) $11,003 Avg Close — Range —