HORIZON PHARMA PLC

CUSIP: G4617B105 Class: SHS

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q1 2017
Shares 480,000 Value ($000) $7,094 Avg Close — Range —
Q4 2016
Shares 300,000 Value ($000) $4,854 Avg Close — Range —
Q3 2016
Shares 535,000 Value ($000) $9,700 Avg Close — Range —
Q2 2016
Shares 50,000 Value ($000) $823 Avg Close — Range —
Q3 2015
Shares 200,000 Value ($000) $3,964 Avg Close — Range —