HORIZON PHARMA PLC

CUSIP: G4617B105 Class: SHS

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q1 2019
Shares 185,000 Value ($000) $4,890 Avg Close — Range —
Q3 2016
Shares 275,000 Value ($000) $4,986 Avg Close — Range —
Q2 2016
Shares 200,000 Value ($000) $3,294 Avg Close — Range —
Q4 2014
Shares 220,000 Value ($000) $2,836 Avg Close — Range —