JAZZ PHARMACEUTICALS PLC

Ticker: JAZZ CUSIP: G50871105 Class: Common Stock

ORBIMED ADVISORS LLC's Holding History (CIK: 0001055951)

Note: Option positions (PUT/CALL) are excluded.

Q3 2018

Shares 884,000 Value ($000) $148,627 Avg Close $171.98 Range $160.15 - $181.46

Q2 2018

Shares 1,040,100 Value ($000) $179,209 Avg Close $163.46 Range $145.13 - $184.00

Q1 2018

Shares 1,040,100 Value ($000) $157,045 Avg Close $146.69 Range $132.88 - $159.72

Q4 2017

Shares 607,900 Value ($000) $81,854 Avg Close $138.70 Range $128.58 - $151.45

Q3 2017

Shares 749,200 Value ($000) $109,571 Avg Close $151.23 Range $139.28 - $162.59

Q2 2017

Shares 545,900 Value ($000) $84,887 Avg Close $152.92 Range $139.72 - $163.75

Q1 2017

Shares 371,400 Value ($000) $53,901 Avg Close $130.25 Range $109.14 - $148.14

Q4 2016

Shares 371,400 Value ($000) $40,494 Avg Close $111.38 Range $95.80 - $126.36

Q3 2016

Shares 246,900 Value ($000) $29,993 Avg Close $134.79 Range $117.34 - $153.98

Q2 2016

Shares 90,000 Value ($000) $12,718 Avg Close $147.42 Range $129.00 - $160.00

Q1 2016

Shares 90,000 Value ($000) $11,750 Avg Close $124.48 Range $108.50 - $139.55

Q4 2015

Shares 90,000 Value ($000) $12,650 Avg Close $138.57 Range $117.26 - $151.28

Q3 2015

Shares 115,000 Value ($000) $15,273 Avg Close $172.18 Range $121.12 - $194.73

Q2 2015

Shares 115,000 Value ($000) $20,248 Avg Close $179.59 Range $165.00 - $191.01

Q1 2015

Shares 115,000 Value ($000) $19,871 Avg Close $171.62 Range $155.06 - $190.17

Q4 2014

Shares 115,000 Value ($000) $18,829 Avg Close $165.98 Range $137.34 - $183.84

Q3 2014

Shares 115,000 Value ($000) $18,464 Avg Close $153.75 Range $131.69 - $176.36

Q2 2014

Shares 115,000 Value ($000) $16,906 Avg Close $138.69 Range $120.38 - $156.34

Q1 2014

Shares 115,000 Value ($000) $15,948 Avg Close $150.52 Range $123.55 - $176.60

Q4 2013

Shares 115,000 Value ($000) $14,554 Avg Close $103.48 Range $80.40 - $128.49

Q3 2013

Shares 72,000 Value ($000) $6,622 Avg Close $80.67 Range $69.00 - $93.84

Q2 2013

Shares 72,000 Value ($000) $4,949 Avg Close $61.12 Range $50.76 - $72.00

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2018	884,000	$148,627	$171.98	$160.15 - $181.46
Q2 2018	1,040,100	$179,209	$163.46	$145.13 - $184.00
Q1 2018	1,040,100	$157,045	$146.69	$132.88 - $159.72
Q4 2017	607,900	$81,854	$138.70	$128.58 - $151.45
Q3 2017	749,200	$109,571	$151.23	$139.28 - $162.59
Q2 2017	545,900	$84,887	$152.92	$139.72 - $163.75
Q1 2017	371,400	$53,901	$130.25	$109.14 - $148.14
Q4 2016	371,400	$40,494	$111.38	$95.80 - $126.36
Q3 2016	246,900	$29,993	$134.79	$117.34 - $153.98
Q2 2016	90,000	$12,718	$147.42	$129.00 - $160.00
Q1 2016	90,000	$11,750	$124.48	$108.50 - $139.55
Q4 2015	90,000	$12,650	$138.57	$117.26 - $151.28
Q3 2015	115,000	$15,273	$172.18	$121.12 - $194.73
Q2 2015	115,000	$20,248	$179.59	$165.00 - $191.01
Q1 2015	115,000	$19,871	$171.62	$155.06 - $190.17
Q4 2014	115,000	$18,829	$165.98	$137.34 - $183.84
Q3 2014	115,000	$18,464	$153.75	$131.69 - $176.36
Q2 2014	115,000	$16,906	$138.69	$120.38 - $156.34
Q1 2014	115,000	$15,948	$150.52	$123.55 - $176.60
Q4 2013	115,000	$14,554	$103.48	$80.40 - $128.49
Q3 2013	72,000	$6,622	$80.67	$69.00 - $93.84
Q2 2013	72,000	$4,949	$61.12	$50.76 - $72.00