PROTHENA CORP PLC

Ticker: PRTA CUSIP: G72800108 Class: Common Stock

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q2 2017

Shares 85,000 Value ($000) $4,600 Avg Close $53.29 Range $48.23 - $59.10

Q1 2017

Shares 87,100 Value ($000) $4,859 Avg Close $52.54 Range $45.13 - $63.14

Q4 2016

Shares 82,500 Value ($000) $4,058 Avg Close $55.18 Range $40.58 - $68.18

Q3 2016

Shares 50,000 Value ($000) $2,999 Avg Close $53.65 Range $35.04 - $64.50

Q1 2016

Shares 14,000 Value ($000) $576 Avg Close $39.14 Range $28.20 - $67.32

Q3 2014

Shares 157,000 Value ($000) $3,479,120 Avg Close $21.20 Range $16.71 - $24.31

Q2 2014

Shares 13,104 Value ($000) $295 Avg Close $25.01 Range $18.52 - $41.33

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2017	85,000	$4,600	$53.29	$48.23 - $59.10
Q1 2017	87,100	$4,859	$52.54	$45.13 - $63.14
Q4 2016	82,500	$4,058	$55.18	$40.58 - $68.18
Q3 2016	50,000	$2,999	$53.65	$35.04 - $64.50
Q1 2016	14,000	$576	$39.14	$28.20 - $67.32
Q3 2014	157,000	$3,479,120	$21.20	$16.71 - $24.31
Q2 2014	13,104	$295	$25.01	$18.52 - $41.33