STRONGBRIDGE BIOPHARMA PLC

CUSIP: G85347105 Class: SHS USD

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q1 2019
Shares 951,600 Value ($000) $4,739 Avg Close — Range —
Q4 2018
Shares 931,600 Value ($000) $4,174 Avg Close — Range —
Q3 2018
Shares 1,179,010 Value ($000) $5,718 Avg Close — Range —
Q2 2018
Shares 673,996 Value ($000) $4,044 Avg Close — Range —
Q1 2016
Shares 60,718 Value ($000) $277 Avg Close — Range —
Q4 2015
Shares 181,818 Value ($000) $1,382 Avg Close — Range —