CRISPR THERAPEUTICS AG

Ticker: CRSP CUSIP: H17182108 Class: NAMEN AKT

Bank Pictet & Cie (Europe) AG's Holding History (CIK: 0001123274)

Note: Option positions (PUT/CALL) are excluded.

Q1 2022

Shares 4,519 Value ($000) $284 Avg Close $62.79 Range $50.54 - $79.40

Q4 2021

Shares 4,076 Value ($000) $309 Avg Close $87.36 Range $67.15 - $112.39

Q3 2021

Shares 3,544 Value ($000) $397 Avg Close $125.59 Range $109.63 - $163.00

Q2 2021

Shares 3,877 Value ($000) $628 Avg Close $121.62 Range $95.11 - $169.76

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2022	4,519	$284	$62.79	$50.54 - $79.40
Q4 2021	4,076	$309	$87.36	$67.15 - $112.39
Q3 2021	3,544	$397	$125.59	$109.63 - $163.00
Q2 2021	3,877	$628	$121.62	$95.11 - $169.76