| ARK Investment Management LLC | 10,522,057 | $551,777 |
| BlackRock, Inc. | 7,508,178 | $393,729 |
| Orbis Allan Gray Ltd | 5,950,145 | $312,026 |
| Capital International Investors | 5,892,745 | $309,016 |
| STATE STREET CORP | 3,753,440 | $196,830 |
| GSK plc | 3,220,627 | $168,890 |
| UBS Group AG | 2,524,144 | $132,366 |
| VANGUARD GROUP INC | 2,268,394 | $118,955 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,249,223 | $117,971 |
| SR ONE CAPITAL MANAGEMENT, LP | 2,038,763 | $106,913 |
| Sumitomo Mitsui Trust Holdings, Inc. | 1,958,111 | $102,683 |
| Nikko Asset Management Americas, Inc. | 1,958,111 | $102,605 |
| FMR LLC | 1,953,957 | $102,466 |
| T. Rowe Price Investment Management, Inc. | 1,845,364 | $97 |
| EcoR1 Capital, LLC | 1,389,276 | $72,854 |
| BANK OF AMERICA CORP /DE/ | 1,096,887 | $57,521 |
| NEA Management Company, LLC | 1,058,570 | $55,511 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,030,182 | $54,023 |
| DIMENSIONAL FUND ADVISORS LP | 907,107 | $47,573 |
| LOOMIS SAYLES & CO L P | 899,331 | $47,161 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 853,971 | $44,782 |
| NORTHERN TRUST CORP | 755,105 | $39,598 |
| MORGAN STANLEY | 667,060 | $34,981 |
| Squarepoint Ops LLC | 581,108 | $30,473 |
| JPMORGAN CHASE & CO | 542,954 | $28,473 |
| NORGES BANK | 490,206 | $25,706 |
| TWO SIGMA INVESTMENTS, LP | 470,621 | $24,679 |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 389,519 | $20,426 |
| WELLS FARGO & COMPANY/MN | 318,878 | $16,722 |
| Bank of New York Mellon Corp | 310,954 | $16,306 |
| AMERIPRISE FINANCIAL INC | 297,244 | $15,568 |
| GOLDMAN SACHS GROUP INC | 275,632 | $14,454 |
| CITADEL ADVISORS LLC | 267,685 | $14,037 |
| BARCLAYS PLC | 249,988 | $13,109 |
| Vestmark Advisory Solutions, Inc. | 249,548 | $13,086 |
| Nuveen, LLC | 183,384 | $9,617 |
| LPL Financial LLC | 170,831 | $8,958 |
| Pictet Asset Management Holding SA | 167,464 | $9,020 |
| RAYMOND JAMES FINANCIAL INC | 167,148 | $8,765 |
| ROYAL BANK OF CANADA | 165,565 | $8,682 |
| TWO SIGMA ADVISERS, LP | 162,400 | $8,516 |
| Swiss National Bank | 161,500 | $8,469 |
| TD Asset Management Inc | 158,416 | $8,307 |
| Contrarius Group Holdings Ltd | 156,605 | $8,212 |
| UBS ASSET MANAGEMENT AMERICAS INC | 148,901 | $7,808 |
| Versant Venture Management, LLC | 148,831 | $7,805 |
| CITIGROUP INC | 132,693 | $6,958 |
| Marex Group plc | 127,546 | $6,689 |
| No Street GP LP | 125,000 | $6,555 |
| RHUMBLINE ADVISERS | 118,778 | $6,229 |
| Reynders McVeigh Capital Management, LLC | 116,514 | $6 |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 116,104 | $6,088 |
| Rockefeller Capital Management L.P. | 112,667 | $5,908 |
| Private Advisor Group, LLC | 107,259 | $5,625 |
| ALGERT GLOBAL LLC | 102,850 | $5 |
| Rafferty Asset Management, LLC | 101,014 | $5,297 |
| Beck Bode, LLC | 98,801 | $5,181 |
| ALLIANCEBERNSTEIN L.P. | 96,357 | $5,053 |
| CAPITAL INTERNATIONAL SARL | 94,769 | $4,970 |
| GROUP ONE TRADING, L.P. | 93,954 | $4,927 |
| Baker Chad R | 93,270 | $4,961 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 89,708 | $4,709 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 89,356 | $5,200 |
| Legal & General Group Plc | 87,911 | $4,610 |
| VAN ECK ASSOCIATES CORP | 85,831 | $5 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 84,940 | $4 |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 84,390 | $4,425 |
| Neo Ivy Capital Management | 78,726 | $4,128 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 78,123 | $4,097 |
| COMMONWEALTH EQUITY SERVICES, LLC | 78,113 | $4,096 |
| Slow Capital, Inc. | 76,630 | $4,018 |
| DEUTSCHE BANK AG\ | 70,492 | $3,697 |
| Cetera Investment Advisers | 63,913 | $3,352 |
| CONGRESS ASSET MANAGEMENT CO /MA | 63,336 | $3,321 |
| NWAM LLC | 61,843 | $3,380 |
| Invesco Ltd. | 60,796 | $3,188 |
| OSAIC HOLDINGS, INC. | 59,211 | $3,105 |
| JONES FINANCIAL COMPANIES LLLP | 57,489 | $3,015 |
| EverSource Wealth Advisors, LLC | 57,465 | $3,013 |
| GUGGENHEIM CAPITAL LLC | 57,021 | $2,990 |
| ENVESTNET ASSET MANAGEMENT INC | 56,572 | $2,967 |
| Green Alpha Advisors, LLC | 55,737 | $2,923 |
| CAPITAL INTERNATIONAL LTD /CA/ | 55,519 | $2,911 |
| BENJAMIN EDWARDS INC | 54,636 | $2,865 |
| FIRST TRUST ADVISORS LP | 54,325 | $2,849 |
| NATIONAL BANK OF CANADA /FI/ | 53,525 | $2,807 |
| STIFEL FINANCIAL CORP | 52,180 | $2,736 |
| Curi Capital, LLC | 50,591 | $2,653 |
| LAZARD ASSET MANAGEMENT LLC | 50,246 | $2,635 |
| STATE OF WISCONSIN INVESTMENT BOARD | 48,172 | $2,526 |
| MetLife Investment Management, LLC | 48,011 | $2,518 |
| Cambridge Investment Research Advisors, Inc. | 44,408 | $2 |
| Privium Fund Management B.V. | 42,874 | $2,248 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 41,530 | $2,178 |
| Palo Alto Investors LP | 41,226 | $2,162 |
| DekaBank Deutsche Girozentrale | 40,745 | $2 |
| Qsemble Capital Management, LP | 40,586 | $2,128 |
| State of New Jersey Common Pension Fund D | 40,338 | $2,115 |
| TUDOR INVESTMENT CORP ET AL | 39,468 | $2,070 |
| Wealth Enhancement Trust Services, Inc. | 38,753 | $2,032 |
| 373 other institutions | 2,592,824 | $127,400 |