CRISPR THERAPEUTICS AG

Ticker: CRSP CUSIP: H17182108 Class: NAMEN AKT

Palo Alto Investors LP's Holding History (CIK: 0001306923)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 41,226 Value ($000) $2,162 Avg Close $59.89 Range $48.02 - $78.48

Q3 2025

Shares 41,226 Value ($000) $2,672 Avg Close $57.41 Range $46.60 - $71.13

Q2 2025

Shares 44,625 Value ($000) $2,171 Avg Close $38.70 Range $30.04 - $51.52

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	41,226	$2,162	$59.89	$48.02 - $78.48
Q3 2025	41,226	$2,672	$57.41	$46.60 - $71.13
Q2 2025	44,625	$2,171	$38.70	$30.04 - $51.52