CRISPR THERAPEUTICS AG

Ticker: CRSP CUSIP: H17182108 Class: NAMEN AKT

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q2 2023

Shares 6,864 Value ($000) $385 Avg Close $56.74 Range $43.10 - $72.00

Q4 2022

Shares 15,501 Value ($000) $630 Avg Close $53.05 Range $38.94 - $66.31

Q3 2022

Shares 10,520 Value ($000) $687 Avg Close $72.47 Range $60.41 - $86.95

Q2 2022

Shares 8,254 Value ($000) $502 Avg Close $58.79 Range $42.51 - $75.42

Q4 2021

Shares 5,518 Value ($000) $418 Avg Close $87.36 Range $67.15 - $112.39

Q2 2021

Shares 1,537 Value ($000) $249 Avg Close $121.62 Range $95.11 - $169.76

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2023	6,864	$385	$56.74	$43.10 - $72.00
Q4 2022	15,501	$630	$53.05	$38.94 - $66.31
Q3 2022	10,520	$687	$72.47	$60.41 - $86.95
Q2 2022	8,254	$502	$58.79	$42.51 - $75.42
Q4 2021	5,518	$418	$87.36	$67.15 - $112.39
Q2 2021	1,537	$249	$121.62	$95.11 - $169.76