CRISPR THERAPEUTICS AG

Ticker: CRSP CUSIP: H17182108 Class: NAMEN AKT

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 162,400 Value ($000) $8,516 Avg Close $59.89 Range $48.02 - $78.48

Q3 2025

Shares 572,972 Value ($000) $37,134 Avg Close $57.41 Range $46.60 - $71.13

Q2 2025

Shares 1,344,700 Value ($000) $65,406 Avg Close $38.70 Range $30.04 - $51.52

Q1 2025

Shares 797,200 Value ($000) $27,129 Avg Close $42.39 Range $32.96 - $55.88

Q4 2024

Shares 84,800 Value ($000) $3,338 Avg Close $47.22 Range $38.20 - $59.07

Q3 2024

Shares 56,400 Value ($000) $2,650 Avg Close $50.74 Range $43.42 - $63.68

Q3 2023

Shares 9,600 Value ($000) $436 Avg Close $51.65 Range $44.53 - $59.67

Q2 2023

Shares 17,300 Value ($000) $971 Avg Close $56.74 Range $43.10 - $72.00

Q3 2021

Shares 220,600 Value ($000) $24,692 Avg Close $125.59 Range $109.63 - $163.00

Q2 2021

Shares 904,800 Value ($000) $146,478 Avg Close $121.62 Range $95.11 - $169.76

Q1 2021

Shares 1,027,700 Value ($000) $125,225 Avg Close $151.00 Range $100.00 - $220.20

Q4 2020

Shares 359,700 Value ($000) $55,074 Avg Close $118.20 Range $79.31 - $181.42

Q3 2020

Shares 322,500 Value ($000) $26,974 Avg Close $88.70 Range $74.00 - $105.12

Q2 2020

Shares 233,700 Value ($000) $17,175 Avg Close $58.47 Range $38.10 - $79.92

Q1 2020

Shares 226,900 Value ($000) $9,623 Avg Close $51.63 Range $32.30 - $64.19

Q4 2019

Shares 287,700 Value ($000) $17,522 Avg Close $54.60 Range $35.46 - $74.00

Q3 2019

Shares 57,300 Value ($000) $2,349 Avg Close $47.78 Range $40.70 - $53.90

Q2 2019

Shares 112,100 Value ($000) $5,280 Avg Close $39.97 Range $34.91 - $48.30

Q1 2019

Shares 239,400 Value ($000) $8,551 Avg Close $34.57 Range $27.15 - $42.03

Q4 2018

Shares 473,100 Value ($000) $13,516 Avg Close $34.76 Range $22.22 - $44.60

Q3 2018

Shares 413,100 Value ($000) $18,321 Avg Close $52.37 Range $43.68 - $66.26

Q2 2018

Shares 368,600 Value ($000) $21,659 Avg Close $56.97 Range $40.25 - $73.90

Q1 2018

Shares 34,400 Value ($000) $1,572 Avg Close $41.27 Range $23.01 - $61.24

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	162,400	$8,516	$59.89	$48.02 - $78.48
Q3 2025	572,972	$37,134	$57.41	$46.60 - $71.13
Q2 2025	1,344,700	$65,406	$38.70	$30.04 - $51.52
Q1 2025	797,200	$27,129	$42.39	$32.96 - $55.88
Q4 2024	84,800	$3,338	$47.22	$38.20 - $59.07
Q3 2024	56,400	$2,650	$50.74	$43.42 - $63.68
Q3 2023	9,600	$436	$51.65	$44.53 - $59.67
Q2 2023	17,300	$971	$56.74	$43.10 - $72.00
Q3 2021	220,600	$24,692	$125.59	$109.63 - $163.00
Q2 2021	904,800	$146,478	$121.62	$95.11 - $169.76
Q1 2021	1,027,700	$125,225	$151.00	$100.00 - $220.20
Q4 2020	359,700	$55,074	$118.20	$79.31 - $181.42
Q3 2020	322,500	$26,974	$88.70	$74.00 - $105.12
Q2 2020	233,700	$17,175	$58.47	$38.10 - $79.92
Q1 2020	226,900	$9,623	$51.63	$32.30 - $64.19
Q4 2019	287,700	$17,522	$54.60	$35.46 - $74.00
Q3 2019	57,300	$2,349	$47.78	$40.70 - $53.90
Q2 2019	112,100	$5,280	$39.97	$34.91 - $48.30
Q1 2019	239,400	$8,551	$34.57	$27.15 - $42.03
Q4 2018	473,100	$13,516	$34.76	$22.22 - $44.60
Q3 2018	413,100	$18,321	$52.37	$43.68 - $66.26
Q2 2018	368,600	$21,659	$56.97	$40.25 - $73.90
Q1 2018	34,400	$1,572	$41.27	$23.01 - $61.24