| BAKER BROS. ADVISORS LP | 12,094,094 | $126,988 |
| RTW INVESTMENTS, LP | 11,433,354 | $120,050 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 11,190,129 | $117,496 |
| PERCEPTIVE ADVISORS LLC | 10,383,456 | $109,026 |
| Vestal Point Capital, LP | 6,125,000 | $64,313 |
| Jefferies Financial Group Inc. | 5,059,551 | $53,125 |
| T. Rowe Price Investment Management, Inc. | 4,789,996 | $50 |
| Sofinnova Investments, Inc. | 3,435,542 | $36,073 |
| MORGAN STANLEY | 2,089,796 | $21,943 |
| Point72 Asset Management, L.P. | 1,754,181 | $18,419 |
| CITADEL ADVISORS LLC | 1,714,961 | $18,007 |
| WELLINGTON MANAGEMENT GROUP LLP | 1,635,231 | $17,170 |
| Woodline Partners LP | 1,000,597 | $10,506 |
| Lynx1 Capital Management LP | 921,950 | $9,680 |
| SPHERA FUNDS MANAGEMENT LTD. | 861,105 | $9,042 |
| Alyeska Investment Group, L.P. | 789,163 | $8,286 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 748,035 | $8 |
| abrdn plc | 714,569 | $7,503 |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 697,431 | $7,323 |
| STEMPOINT CAPITAL LP | 610,308 | $6,408 |
| BALYASNY ASSET MANAGEMENT L.P. | 592,428 | $6,220 |
| UBS Group AG | 563,463 | $5,916 |
| Caption Management, LLC | 550,891 | $5,784 |
| WASATCH ADVISORS LP | 515,128 | $5,409 |
| TD Asset Management Inc | 500,724 | $5,258 |
| STATE STREET CORP | 444,658 | $4,669 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 402,352 | $4,052 |
| GOLDMAN SACHS GROUP INC | 323,023 | $3,392 |
| DAFNA Capital Management LLC | 261,138 | $2,742 |
| SG Americas Securities, LLC | 208,456 | $2 |
| Verition Fund Management LLC | 206,568 | $2,169 |
| NORTHERN TRUST CORP | 203,449 | $2,136 |
| Monashee Investment Management LLC | 160,336 | $1,684 |
| Burkehill Global Management, LP | 150,000 | $1,575 |
| Qube Research & Technologies Ltd | 147,328 | $1,547 |
| JPMORGAN CHASE & CO | 146,972 | $1,543 |
| GEODE CAPITAL MANAGEMENT, LLC | 134,763 | $1,415 |
| MYDA Advisors LLC | 120,000 | $1,260 |
| BNP PARIBAS ARBITRAGE, SA | 116,646 | $1,225 |
| ALPS ADVISORS INC | 110,082 | $1,156 |
| JANE STREET GROUP, LLC | 104,929 | $1,102 |
| SummitTX Capital, L.P. | 96,784 | $1,016 |
| MILLENNIUM MANAGEMENT LLC | 83,122 | $873 |
| Ishara Investments LP | 80,000 | $840 |
| SECTORAL ASSET MANAGEMENT INC | 63,015 | $662 |
| CITIGROUP INC | 56,367 | $592 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 55,300 | $557 |
| TUDOR INVESTMENT CORP ET AL | 54,720 | $575 |
| Jump Financial, LLC | 50,868 | $534 |
| Vanguard Personalized Indexing Management, LLC | 49,374 | $518 |
| Ikarian Capital, LLC | 48,569 | $510 |
| Longaeva Partners L.P. | 44,601 | $468 |
| MERCER GLOBAL ADVISORS INC /ADV | 29,987 | $315 |
| BARCLAYS PLC | 28,185 | $296 |
| Virtus Investment Advisers, LLC | 26,497 | $278 |
| BlackRock, Inc. | 25,554 | $268 |
| J. Goldman & Co LP | 22,788 | $239 |
| Aquatic Capital Management LLC | 20,220 | $212 |
| Graham Capital Management, L.P. | 19,630 | $206 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 17,024 | $179 |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 16,955 | $177 |
| GUGGENHEIM CAPITAL LLC | 16,402 | $172 |
| Pale Fire Capital SE | 16,272 | $171 |
| BANK OF AMERICA CORP /DE/ | 13,546 | $142 |
| Mariner, LLC | 13,405 | $141 |
| FOX RUN MANAGEMENT, L.L.C. | 12,307 | $129 |
| XTX Topco Ltd | 11,234 | $118 |
| Quarry LP | 8,001 | $84 |
| OSAIC HOLDINGS, INC. | 5,175 | $54 |
| WELLS FARGO & COMPANY/MN | 651 | $7 |
| Farther Finance Advisors, LLC | 528 | $6 |
| NewEdge Advisors, LLC | 100 | $1 |
| Clearstead Advisors, LLC | 25 | $0 |
| SBI Securities Co., Ltd. | 25 | $0 |
| HUNTINGTON NATIONAL BANK | 1 | $0 |