UNIQURE NV

Ticker: QURE CUSIP: N90064101 Class: Common Stock

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 16,462 Value ($000) $391 Avg Close $38.59 Range $19.29 - $71.50

Q3 2025

Shares 48,762 Value ($000) $2,846 Avg Close $18.16 Range $12.33 - $60.70

Q2 2023

Shares 18,700 Value ($000) $214 Avg Close $18.95 Range $10.51 - $22.48

Q2 2022

Shares 22,646 Value ($000) $418 Avg Close $15.91 Range $12.52 - $20.72

Q1 2022

Shares 23,489 Value ($000) $420 Avg Close $17.46 Range $14.29 - $21.85

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	16,462	$391	$38.59	$19.29 - $71.50
Q3 2025	48,762	$2,846	$18.16	$12.33 - $60.70
Q2 2023	18,700	$214	$18.95	$10.51 - $22.48
Q2 2022	22,646	$418	$15.91	$12.52 - $20.72
Q1 2022	23,489	$420	$17.46	$14.29 - $21.85