| FMR LLC | 6,240,936 | $149,346 |
| Avoro Capital Advisors LLC | 6,150,000 | $147,170 |
| RTW INVESTMENTS, LP | 3,711,462 | $88,815 |
| abrdn plc | 3,678,640 | $88,030 |
| STATE STREET CORP | 3,231,043 | $77,319 |
| JPMORGAN CHASE & CO | 2,934,626 | $70,226 |
| BlackRock, Inc. | 1,974,988 | $47,261 |
| TWO SIGMA INVESTMENTS, LP | 1,451,284 | $34,729 |
| MPM BioImpact LLC | 1,381,628 | $33,062 |
| JENNISON ASSOCIATES LLC | 1,371,190 | $32,813 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,218,350 | $29,155 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,216,734 | $29,116 |
| GOLDMAN SACHS GROUP INC | 1,167,608 | $27,941 |
| TWO SIGMA ADVISERS, LP | 1,110,400 | $26,572 |
| VANGUARD GROUP INC | 1,051,379 | $25,160 |
| Artia Global Partners LP | 1,023,539 | $24,493 |
| Integral Health Asset Management, LLC | 900,000 | $21,537 |
| MILLENNIUM MANAGEMENT LLC | 803,605 | $19,230 |
| GEODE CAPITAL MANAGEMENT, LLC | 776,071 | $18,578 |
| Fiera Capital Corp | 768,510 | $18,390 |
| FRANKLIN RESOURCES INC | 746,602 | $17,866 |
| ORBIMED ADVISORS LLC | 737,400 | $17,646 |
| MORGAN STANLEY | 716,927 | $17,156 |
| Nantahala Capital Management, LLC | 699,298 | $16,734 |
| Logos Global Management LP | 675,000 | $16,153 |
| Tyro Capital Management LLC | 663,929 | $15,888 |
| MAVERICK CAPITAL LTD | 661,820 | $15,837 |
| Assenagon Asset Management S.A. | 606,923 | $14,524 |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 521,677 | $12,484 |
| EVENTIDE ASSET MANAGEMENT, LLC | 498,212 | $11,922 |
| UBS Group AG | 491,454 | $11,760 |
| CITADEL ADVISORS LLC | 469,300 | $11,230 |
| Whitefort Capital Management, LP | 459,000 | $10,984 |
| Privium Fund Management B.V. | 416,270 | $9,961 |
| 683 Capital Management, LLC | 384,950 | $9,212 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 362,878 | $8,684 |
| READYSTATE ASSET MANAGEMENT LP | 361,560 | $8,652 |
| FRED ALGER MANAGEMENT, LLC | 344,878 | $8,253 |
| BANK OF AMERICA CORP /DE/ | 329,525 | $7,886 |
| First Turn Management, LLC | 321,655 | $7,697 |
| HRT FINANCIAL LP | 310,050 | $7 |
| Jump Financial, LLC | 306,131 | $7,326 |
| Boxer Capital Management, LLC | 290,000 | $6,940 |
| Catalio Capital Management, LP | 288,345 | $6,900 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 258,211 | $6,179 |
| Parkman Healthcare Partners LLC | 257,382 | $6,159 |
| ADAR1 Capital Management, LLC | 235,155 | $5,627 |
| Freshford Capital Management, LLC | 229,613 | $5,495 |
| BNP PARIBAS ARBITRAGE, SA | 221,343 | $5,297 |
| Voss Capital, LLC | 210,000 | $5,025 |
| BARCLAYS PLC | 209,790 | $5,020 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 208,646 | $5 |
| Eagle Health Investments LP | 205,247 | $4,912 |
| CITIGROUP INC | 184,765 | $4,421 |
| Caption Management, LLC | 177,277 | $4,242 |
| Sofinnova Investments, Inc. | 176,513 | $4,224 |
| Squarepoint Ops LLC | 176,000 | $4,212 |
| NORTHERN TRUST CORP | 168,820 | $4,040 |
| Rafferty Asset Management, LLC | 164,937 | $3,947 |
| Alyeska Investment Group, L.P. | 151,058 | $3,615 |
| NEW YORK STATE COMMON RETIREMENT FUND | 147,549 | $3,531 |
| FLAX POND CAPITAL, LLC | 146,498 | $3,506 |
| BALYASNY ASSET MANAGEMENT L.P. | 135,644 | $3,246 |
| D. E. Shaw & Co., Inc. | 131,956 | $3,158 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 126,047 | $3,016 |
| Hudson Bay Capital Management LP | 125,500 | $3,003 |
| Schonfeld Strategic Advisors LLC | 122,529 | $2,932 |
| NAN FUNG TRINITY (HK) LTD | 115,494 | $2,764 |
| SIMPLEX TRADING, LLC | 110,675 | $2,648 |
| ENVESTNET ASSET MANAGEMENT INC | 99,593 | $2,383 |
| Ikarian Capital, LLC | 91,060 | $2,179 |
| Jefferies Financial Group Inc. | 90,542 | $2,167 |
| Marex Group plc | 85,993 | $2,058 |
| ROYAL BANK OF CANADA | 85,640 | $2,050 |
| Clearline Capital LP | 83,681 | $2,002 |
| CAPITAL FUND MANAGEMENT S.A. | 82,978 | $1,986 |
| UBS ASSET MANAGEMENT AMERICAS INC | 80,249 | $1,920 |
| Rhenman & Partners Asset Management AB | 79,375 | $1,899 |
| Swiss National Bank | 79,000 | $1,890 |
| Walleye Capital LLC | 78,996 | $1,890 |
| Atom Investors LP | 78,209 | $1,872 |
| MOORE CAPITAL MANAGEMENT, LP | 75,000 | $1,795 |
| TUDOR INVESTMENT CORP ET AL | 74,036 | $1,772 |
| ExodusPoint Capital Management, LP | 73,775 | $1,765 |
| ALGERT GLOBAL LLC | 72,150 | $2 |
| AMERIPRISE FINANCIAL INC | 70,796 | $1,694 |
| WELLS FARGO & COMPANY/MN | 70,236 | $1,681 |
| Hennion & Walsh Asset Management, Inc. | 67,739 | $1,621 |
| SG Americas Securities, LLC | 64,326 | $2 |
| Eversept Partners, LP | 62,820 | $1,503 |
| PROFUND ADVISORS LLC | 59,463 | $1,423 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 55,015 | $1,308 |
| Senvest Management, LLC | 50,000 | $1,197 |
| Affinity Asset Advisors, LLC | 50,000 | $1,197 |
| WINTON GROUP Ltd | 48,185 | $1,153 |
| STIFEL FINANCIAL CORP | 45,987 | $1,100 |
| Y-Intercept (Hong Kong) Ltd | 45,778 | $1,095 |
| DIADEMA PARTNERS LP | 45,000 | $1,077 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 44,250 | $1,057 |
| STEMPOINT CAPITAL LP | 43,485 | $1,041 |
| 122 other institutions | 1,501,202 | $35,691 |