UNIQURE NV

Ticker: QURE CUSIP: N90064101 Class: Common Stock

D. E. Shaw & Co., Inc.'s Holding History (CIK: 0001009207)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 131,956 Value ($000) $3,158 Avg Close $38.59 Range $19.29 - $71.50

Q3 2025

Shares 32,537 Value ($000) $1,899 Avg Close $18.16 Range $12.33 - $60.70

Q2 2025

Shares 27,531 Value ($000) $384 Avg Close $13.45 Range $7.76 - $17.60

Q4 2024

Shares 299,771 Value ($000) $5,294 Avg Close $8.63 Range $4.45 - $18.42

Q3 2024

Shares 743,498 Value ($000) $3,665 Avg Close $6.51 Range $3.73 - $11.35

Q2 2024

Shares 576,008 Value ($000) $2,581 Avg Close $4.87 Range $4.25 - $5.62

Q1 2024

Shares 850,100 Value ($000) $4,421 Avg Close $5.74 Range $4.76 - $7.12

Q4 2023

Shares 560,331 Value ($000) $3,793 Avg Close $6.61 Range $5.49 - $8.66

Q3 2023

Shares 411,736 Value ($000) $2,763 Avg Close $9.00 Range $6.64 - $11.95

Q2 2023

Shares 20,115 Value ($000) $231 Avg Close $18.95 Range $10.51 - $22.48

Q2 2022

Shares 11,300 Value ($000) $211 Avg Close $15.91 Range $12.52 - $20.72

Q4 2020

Shares 23,702 Value ($000) $856 Avg Close $42.18 Range $34.38 - $52.19

Q2 2020

Shares 18,662 Value ($000) $841 Avg Close $59.06 Range $44.63 - $71.45

Q1 2020

Shares 17,507 Value ($000) $831 Avg Close $57.46 Range $37.50 - $76.69

Q4 2019

Shares 6,119 Value ($000) $438 Avg Close $54.91 Range $36.20 - $76.09

Q3 2019

Shares 26,441 Value ($000) $1,041 Avg Close $57.69 Range $38.07 - $77.46

Q1 2019

Shares 122,660 Value ($000) $7,317 Avg Close $44.67 Range $26.94 - $69.60

Q4 2018

Shares 29,657 Value ($000) $855 Avg Close $27.83 Range $21.98 - $37.30

Q3 2018

Shares 68,153 Value ($000) $2,480 Avg Close $37.20 Range $28.00 - $43.23

Q2 2018

Shares 97,047 Value ($000) $3,669 Avg Close $32.02 Range $21.57 - $40.98

Q1 2018

Shares 97,044 Value ($000) $2,281 Avg Close $21.81 Range $16.77 - $27.19

Q4 2017

Shares 106,442 Value ($000) $2,085 Avg Close $15.23 Range $9.47 - $21.35

Q4 2015

Shares 24,748 Value ($000) $409 Avg Close $18.53 Range $15.05 - $22.93

Q3 2015

Shares 49,838 Value ($000) $1,019 Avg Close $26.34 Range $18.51 - $36.38

Q2 2015

Shares 25,100 Value ($000) $678 Avg Close $28.48 Range $22.51 - $35.50

Q3 2014

Shares 24,287 Value ($000) $224 Avg Close $10.98 Range $9.00 - $14.50

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	131,956	$3,158	$38.59	$19.29 - $71.50
Q3 2025	32,537	$1,899	$18.16	$12.33 - $60.70
Q2 2025	27,531	$384	$13.45	$7.76 - $17.60
Q4 2024	299,771	$5,294	$8.63	$4.45 - $18.42
Q3 2024	743,498	$3,665	$6.51	$3.73 - $11.35
Q2 2024	576,008	$2,581	$4.87	$4.25 - $5.62
Q1 2024	850,100	$4,421	$5.74	$4.76 - $7.12
Q4 2023	560,331	$3,793	$6.61	$5.49 - $8.66
Q3 2023	411,736	$2,763	$9.00	$6.64 - $11.95
Q2 2023	20,115	$231	$18.95	$10.51 - $22.48
Q2 2022	11,300	$211	$15.91	$12.52 - $20.72
Q4 2020	23,702	$856	$42.18	$34.38 - $52.19
Q2 2020	18,662	$841	$59.06	$44.63 - $71.45
Q1 2020	17,507	$831	$57.46	$37.50 - $76.69
Q4 2019	6,119	$438	$54.91	$36.20 - $76.09
Q3 2019	26,441	$1,041	$57.69	$38.07 - $77.46
Q1 2019	122,660	$7,317	$44.67	$26.94 - $69.60
Q4 2018	29,657	$855	$27.83	$21.98 - $37.30
Q3 2018	68,153	$2,480	$37.20	$28.00 - $43.23
Q2 2018	97,047	$3,669	$32.02	$21.57 - $40.98
Q1 2018	97,044	$2,281	$21.81	$16.77 - $27.19
Q4 2017	106,442	$2,085	$15.23	$9.47 - $21.35
Q4 2015	24,748	$409	$18.53	$15.05 - $22.93
Q3 2015	49,838	$1,019	$26.34	$18.51 - $36.38
Q2 2015	25,100	$678	$28.48	$22.51 - $35.50
Q3 2014	24,287	$224	$10.98	$9.00 - $14.50