UNIQURE NV

Ticker: QURE CUSIP: N90064101 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,451,284 Value ($000) $34,729 Avg Close $38.59 Range $19.29 - $71.50

Q3 2025

Shares 897,538 Value ($000) $52,389 Avg Close $18.16 Range $12.33 - $60.70

Q2 2025

Shares 940,960 Value ($000) $13,117 Avg Close $13.45 Range $7.76 - $17.60

Q1 2025

Shares 916,499 Value ($000) $9,715 Avg Close $14.02 Range $9.38 - $19.18

Q4 2024

Shares 878,884 Value ($000) $15,521 Avg Close $8.63 Range $4.45 - $18.42

Q3 2024

Shares 804,896 Value ($000) $3,968 Avg Close $6.51 Range $3.73 - $11.35

Q2 2024

Shares 119,276 Value ($000) $534 Avg Close $4.87 Range $4.25 - $5.62

Q1 2024

Shares 236,277 Value ($000) $1,229 Avg Close $5.74 Range $4.76 - $7.12

Q4 2023

Shares 121,976 Value ($000) $826 Avg Close $6.61 Range $5.49 - $8.66

Q3 2023

Shares 61,359 Value ($000) $412 Avg Close $9.00 Range $6.64 - $11.95

Q2 2023

Shares 331,382 Value ($000) $3,798 Avg Close $18.95 Range $10.51 - $22.48

Q1 2023

Shares 260,255 Value ($000) $5,242 Avg Close $20.98 Range $18.01 - $23.46

Q4 2022

Shares 266,342 Value ($000) $6,038 Avg Close $21.57 Range $17.85 - $28.25

Q3 2022

Shares 73,398 Value ($000) $1,377 Avg Close $21.02 Range $16.75 - $25.81

Q3 2021

Shares 94,855 Value ($000) $3,036 Avg Close $30.48 Range $25.80 - $38.80

Q1 2021

Shares 158,096 Value ($000) $5,326 Avg Close $35.84 Range $28.58 - $42.27

Q4 2020

Shares 66,166 Value ($000) $2,391 Avg Close $42.18 Range $34.38 - $52.19

Q3 2020

Shares 124,138 Value ($000) $4,572 Avg Close $40.97 Range $35.76 - $48.50

Q4 2019

Shares 28,745 Value ($000) $2,060 Avg Close $54.91 Range $36.20 - $76.09

Q3 2019

Shares 430,879 Value ($000) $16,959 Avg Close $57.69 Range $38.07 - $77.46

Q2 2019

Shares 8,100 Value ($000) $633 Avg Close $63.72 Range $51.85 - $82.49

Q1 2019

Shares 55,180 Value ($000) $3,291 Avg Close $44.67 Range $26.94 - $69.60

Q4 2018

Shares 15,322 Value ($000) $442 Avg Close $27.83 Range $21.98 - $37.30

Q3 2018

Shares 6,091 Value ($000) $222 Avg Close $37.20 Range $28.00 - $43.23

Q4 2017

Shares 138,891 Value ($000) $2,721 Avg Close $15.23 Range $9.47 - $21.35

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,451,284	$34,729	$38.59	$19.29 - $71.50
Q3 2025	897,538	$52,389	$18.16	$12.33 - $60.70
Q2 2025	940,960	$13,117	$13.45	$7.76 - $17.60
Q1 2025	916,499	$9,715	$14.02	$9.38 - $19.18
Q4 2024	878,884	$15,521	$8.63	$4.45 - $18.42
Q3 2024	804,896	$3,968	$6.51	$3.73 - $11.35
Q2 2024	119,276	$534	$4.87	$4.25 - $5.62
Q1 2024	236,277	$1,229	$5.74	$4.76 - $7.12
Q4 2023	121,976	$826	$6.61	$5.49 - $8.66
Q3 2023	61,359	$412	$9.00	$6.64 - $11.95
Q2 2023	331,382	$3,798	$18.95	$10.51 - $22.48
Q1 2023	260,255	$5,242	$20.98	$18.01 - $23.46
Q4 2022	266,342	$6,038	$21.57	$17.85 - $28.25
Q3 2022	73,398	$1,377	$21.02	$16.75 - $25.81
Q3 2021	94,855	$3,036	$30.48	$25.80 - $38.80
Q1 2021	158,096	$5,326	$35.84	$28.58 - $42.27
Q4 2020	66,166	$2,391	$42.18	$34.38 - $52.19
Q3 2020	124,138	$4,572	$40.97	$35.76 - $48.50
Q4 2019	28,745	$2,060	$54.91	$36.20 - $76.09
Q3 2019	430,879	$16,959	$57.69	$38.07 - $77.46
Q2 2019	8,100	$633	$63.72	$51.85 - $82.49
Q1 2019	55,180	$3,291	$44.67	$26.94 - $69.60
Q4 2018	15,322	$442	$27.83	$21.98 - $37.30
Q3 2018	6,091	$222	$37.20	$28.00 - $43.23
Q4 2017	138,891	$2,721	$15.23	$9.47 - $21.35