UNIQURE NV

Ticker: QURE CUSIP: N90064101 Class: Common Stock

Palo Alto Investors LP's Holding History (CIK: 0001306923)

Note: Option positions (PUT/CALL) are excluded.

Q3 2016

Shares 20,453 Value ($000) $156 Avg Close $7.93 Range $6.68 - $9.72

Q2 2016

Shares 20,453 Value ($000) $151 Avg Close $11.96 Range $6.75 - $15.00

Q1 2016

Shares 20,453 Value ($000) $243 Avg Close $14.77 Range $10.61 - $19.40

Q4 2015

Shares 20,453 Value ($000) $338 Avg Close $18.53 Range $15.05 - $22.93

Q3 2015

Shares 20,453 Value ($000) $418 Avg Close $26.34 Range $18.51 - $36.38

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2016	20,453	$156	$7.93	$6.68 - $9.72
Q2 2016	20,453	$151	$11.96	$6.75 - $15.00
Q1 2016	20,453	$243	$14.77	$10.61 - $19.40
Q4 2015	20,453	$338	$18.53	$15.05 - $22.93
Q3 2015	20,453	$418	$26.34	$18.51 - $36.38