Avoro Capital Advisors LLC Diversified Active

Location: New York, NY

CIK: 0001633313 · Show all filings

Period: Q1 2023 (← Previous) (Next →)

Filing Date: May 15, 2023

Total Value: $6.745B (100.0% shares, 0.0% debt)

Holdings (41)

— HORIZON THERAPEUTICS PLC 11.3%

Value $764M Shares 7,000,000 Est. Cost $66.26 Unrealized —

APLS APELLIS PHARMACEUTICALS INC 10.9%

Value $733M Shares 11,111,111 Est. Cost $48.71 Unrealized +18.5%

UTHR UNITED THERAPEUTICS CORP 9.5%

Value $643M Shares 2,870,000 Est. Cost $133.73 Unrealized +84.3%

SRPT SAREPTA THERAPEUTICS INC 7.5%

Value $503M Shares 3,650,000 Est. Cost $101.47 Unrealized +27.8%

ARGX ARGENX SE 7.1%

Value $480M Shares 1,287,500 Est. Cost $140.84 Unrealized —

MDGL MADRIGAL PHARMACEUTICALS INC 6.0%

Value $404M Shares 1,666,666 Est. Cost $118.73 Unrealized +129.5%

BMRN BIOMARIN PHARMACEUTICAL INC 5.7%

Value $384M Shares 3,945,000 Est. Cost $85.62 Unrealized +21.1%

— SEAGEN INC 5.4%

Value $365M Shares 1,801,906 Est. Cost $146.25 Unrealized —

ASND ASCENDIS PHARMA 5.3%

Value $357M Shares 3,325,000 Est. Cost $123.27 Unrealized —

FOLD AMICUS THERAPEUTICS INC 4.5%

Value $303M Shares 27,300,000 Est. Cost $10.47 Unrealized +17.8%

ALNY ALNYLAM PHARMACEUTICALS INC 3.3%

Value $221M Shares 1,105,000 Est. Cost $153.75 Unrealized +36.7%

— MIRATI THERAPEUTICS INC 3.1%

Value $207M Shares 5,555,555 Est. Cost $53.82 Unrealized —

XENE XENON PHARMACEUTICALS INC 2.6%

Value $175M Shares 4,900,000 Est. Cost $16.29 Unrealized +126.8%

— IVERIC BIO INC 2.5%

Value $165M Shares 6,800,000 Est. Cost $8.28 Unrealized —

KRYS KRYSTAL BIOTECH INC 2.1%

Value $140M Shares 1,750,000 Est. Cost $66.44 Unrealized +18.3%

KYMR KYMERA THERAPEUTICS INC 1.7%

Value $114M Shares 3,855,000 Est. Cost $31.77 Unrealized +1.5%

— DICE THERAPEUTICS INC 1.7%

Value $113M Shares 3,950,000 Est. Cost $28.94 Unrealized —

— CYMABAY THERAPEUTICS INC 1.3%

Value $89.82M Shares 10,300,000 Est. Cost $6.26 Unrealized —

BCRX BIOCRYST PHARMACEUTICALS INC 1.3%

Value $86.9M Shares 10,420,000 Est. Cost $11.88 Unrealized -19.0%

SNDX SYNDAX PHARMACEUTICALS INC 0.8%

Value $55.97M Shares 2,650,000 Est. Cost $21.05 Unrealized +18.1%

NUVL NUVALENT INC 0.7%

Value $49.28M Shares 1,888,888 Est. Cost $28.81 Unrealized +2.7%

IOVA IOVANCE BIOTHERAPEUTICS INC 0.6%

Value $42.89M Shares 7,020,000 Est. Cost $16.40 Unrealized -57.9%

RNAM AVIDITY BIOSCIENCES INC 0.6%

Value $38.53M Shares 2,510,000 Est. Cost $21.47 Unrealized +2.5%

KURA KURA ONCOLOGY INC 0.6%

Value $37.97M Shares 3,105,000 Est. Cost $23.38 Unrealized -46.6%

MNKD MANNKIND CORP 0.6%

Value $37.31M Shares 9,100,000 Est. Cost $3.56 Unrealized +35.7%

GLUE MONTE ROSA THERAPEUTICS INC 0.5%

Value $33.69M Shares 4,325,000 Est. Cost $17.56 Unrealized -60.4%

— MERSANA THERAPEUTICS INC 0.5%

Value $31.03M Shares 7,550,000 Est. Cost $21.34 Unrealized —

RARE ULTRAGENYX PHARMACEUTICAL INC 0.4%

Value $30.07M Shares 750,000 Est. Cost $64.00 Unrealized -33.0%

— MARINUS PHARMACEUTICALS INC 0.3%

Value $21.73M Shares 3,150,000 Est. Cost $12.20 Unrealized —

WHWK AADI BIOSCIENCES INC 0.3%

Value $20.63M Shares 2,849,402 Est. Cost $24.27 Unrealized -56.0%

DSGN DESIGN THERAPEUTICS INC 0.3%

Value $20.2M Shares 3,500,000 Est. Cost $19.27 Unrealized -61.2%

— VERRICA PHARMACEUTICALS INC 0.3%

Value $17.23M Shares 2,650,000 Est. Cost $6.50 Unrealized —

PMVP PMV PHARMACEUTICALS INC 0.2%

Value $14.6M Shares 3,060,000 Est. Cost $25.09 Unrealized -71.9%

AMLX AMYLYX PHARMACEUTICALS INC 0.2%

Value $13.88M Shares 473,100 Est. Cost $24.95 Unrealized +39.2%

FENC FENNEC PHARMACEUTICALS INC 0.1%

Value $9.984M Shares 1,200,000 Est. Cost $9.85 Unrealized -5.9%

— SERES THERAPEUTICS INC 0.1%

Value $7.343M Shares 1,295,000 Est. Cost $5.67 Unrealized —

TNGX TANGO THERAPEUTICS INC 0.1%

Value $6.478M Shares 1,640,000 Est. Cost $11.71 Unrealized -50.5%

IOBT IO BIOTECH INC 0.1%

Value $3.845M Shares 2,055,883 Est. Cost $9.66 Unrealized -74.2%

SRPT SAREPTA THERAPEUTICS INC 0.1%

Value $3.675M Shares 250,000 Est. Cost $101.47 Unrealized +27.8%

— IVERIC BIO INC 0.0%

Value $1.837M Shares 875,000 Est. Cost $8.28 Unrealized —

XBI SPDR SERIES TRUST - S&P BIOTECH 0.0%

Value $180K Shares 1,500,000 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	HORIZON THERAPEUTICS PLC	7,000,000	$764M	11.3%	$66.26	—	Common	G46188101
APLS	APELLIS PHARMACEUTICALS INC	11,111,111	$733M	10.9%	$48.71	+18.5%	Common	03753U106
UTHR	UNITED THERAPEUTICS CORP	2,870,000	$643M	9.5%	$133.73	+84.3%	Common	91307C102
SRPT	SAREPTA THERAPEUTICS INC	3,650,000	$503M	7.5%	$101.47	+27.8%	Common	803607100
ARGX	ARGENX SE	1,287,500	$480M	7.1%	$140.84	—	Sponsored ADR	04016X101
MDGL	MADRIGAL PHARMACEUTICALS INC	1,666,666	$404M	6.0%	$118.73	+129.5%	Common	558868105
BMRN	BIOMARIN PHARMACEUTICAL INC	3,945,000	$384M	5.7%	$85.62	+21.1%	Common	09061G101
—	SEAGEN INC	1,801,906	$365M	5.4%	$146.25	—	Common	81181C104
ASND	ASCENDIS PHARMA	3,325,000	$357M	5.3%	$123.27	—	Sponsored ADR	04351P101
FOLD	AMICUS THERAPEUTICS INC	27,300,000	$303M	4.5%	$10.47	+17.8%	Common	03152W109
ALNY	ALNYLAM PHARMACEUTICALS INC	1,105,000	$221M	3.3%	$153.75	+36.7%	Common	02043Q107
—	MIRATI THERAPEUTICS INC	5,555,555	$207M	3.1%	$53.82	—	Common	60468T105
XENE	XENON PHARMACEUTICALS INC	4,900,000	$175M	2.6%	$16.29	+126.8%	Common	98420N105
—	IVERIC BIO INC	6,800,000	$165M	2.5%	$8.28	—	Common	46583P102
KRYS	KRYSTAL BIOTECH INC	1,750,000	$140M	2.1%	$66.44	+18.3%	Common	501147102
KYMR	KYMERA THERAPEUTICS INC	3,855,000	$114M	1.7%	$31.77	+1.5%	Common	501575104
—	DICE THERAPEUTICS INC	3,950,000	$113M	1.7%	$28.94	—	Common	23345J104
—	CYMABAY THERAPEUTICS INC	10,300,000	$89.82M	1.3%	$6.26	—	Common	23257D103
BCRX	BIOCRYST PHARMACEUTICALS INC	10,420,000	$86.9M	1.3%	$11.88	-19.0%	Common	09058V103
SNDX	SYNDAX PHARMACEUTICALS INC	2,650,000	$55.97M	0.8%	$21.05	+18.1%	Common	87164F105
NUVL	NUVALENT INC	1,888,888	$49.28M	0.7%	$28.81	+2.7%	Common	670703107
IOVA	IOVANCE BIOTHERAPEUTICS INC	7,020,000	$42.89M	0.6%	$16.40	-57.9%	Common	462260100
RNAM	AVIDITY BIOSCIENCES INC	2,510,000	$38.53M	0.6%	$21.47	+2.5%	Common	05370A108
KURA	KURA ONCOLOGY INC	3,105,000	$37.97M	0.6%	$23.38	-46.6%	Common	50127T109
MNKD	MANNKIND CORP	9,100,000	$37.31M	0.6%	$3.56	+35.7%	Common	56400P706
GLUE	MONTE ROSA THERAPEUTICS INC	4,325,000	$33.69M	0.5%	$17.56	-60.4%	Common	61225M102
—	MERSANA THERAPEUTICS INC	7,550,000	$31.03M	0.5%	$21.34	—	Common	59045L106
RARE	ULTRAGENYX PHARMACEUTICAL INC	750,000	$30.07M	0.4%	$64.00	-33.0%	Common	90400D108
—	MARINUS PHARMACEUTICALS INC	3,150,000	$21.73M	0.3%	$12.20	—	Common	56854Q200
WHWK	AADI BIOSCIENCES INC	2,849,402	$20.63M	0.3%	$24.27	-56.0%	Common	00032Q104
DSGN	DESIGN THERAPEUTICS INC	3,500,000	$20.2M	0.3%	$19.27	-61.2%	Common	25056L103
—	VERRICA PHARMACEUTICALS INC	2,650,000	$17.23M	0.3%	$6.50	—	Common	92511W108
PMVP	PMV PHARMACEUTICALS INC	3,060,000	$14.6M	0.2%	$25.09	-71.9%	Common	69353Y103
AMLX	AMYLYX PHARMACEUTICALS INC	473,100	$13.88M	0.2%	$24.95	+39.2%	Common	03237H101
FENC	FENNEC PHARMACEUTICALS INC	1,200,000	$9.984M	0.1%	$9.85	-5.9%	Common	31447P100
—	SERES THERAPEUTICS INC	1,295,000	$7.343M	0.1%	$5.67	—	Common	81750R102
TNGX	TANGO THERAPEUTICS INC	1,640,000	$6.478M	0.1%	$11.71	-50.5%	Common	87583X109
IOBT	IO BIOTECH INC	2,055,883	$3.845M	0.1%	$9.66	-74.2%	Common	449778109
SRPT	SAREPTA THERAPEUTICS INC	250,000	$3.675M	0.1%	$101.47	+27.8%	Call	803607100
—	IVERIC BIO INC	875,000	$1.837M	0.0%	$8.28	—	Call	46583P102
XBI	SPDR SERIES TRUST - S&P BIOTECH	1,500,000	$180K	0.0%	—	—	Call	78464A870