EcoR1 Capital, LLC Quant / Systematic

Location: San Francisco, CA

CIK: 0001587114 · Show all filings

Period: Q1 2016 (← Previous) (Next →)

Filing Date: May 16, 2016

Total Value: $286M (93.4% shares, 6.6% debt)

Holdings (37)

IRWD IRONWOOD PHARMACEUTICALS INC 7.9%

Value $22.55M Shares 2,061,417 Est. Cost $8.81 Unrealized -6.4%

— FIVE PRIME THERAPEUTICS INC 7.1%

Value $20.35M Shares 500,757 Est. Cost $36.09 Unrealized —

— EPIZYME INC 6.8%

Value $19.38M Shares 1,598,900 Est. Cost $15.17 Unrealized —

— FIBROGEN INC 6.4%

Value $18.39M Shares 863,745 Est. Cost $24.72 Unrealized —

— ARRAY BIOPHARMA INC 6.3%

Value $18.14M Shares 22,534,000 Est. Cost $0.81 Unrealized —

— RETROPHIN INC 5.8%

Value $16.73M Shares 1,225,084 Est. Cost $21.12 Unrealized —

— SPDR SERIES TRUST S&P BIOTECH 5.4%

Value $15.35M Shares 297,200 Est. Cost — Unrealized —

CYTK CYTOKINETICS INC 5.1%

Value $14.47M Shares 2,052,800 Est. Cost $9.04 Unrealized -19.1%

— GILEAD SCIENCES INC 4.8%

Value $13.78M Shares 150,000 Est. Cost — Unrealized —

— ASSEMBLY BIOSCIENCES INC 3.7%

Value $10.53M Shares 2,098,302 Est. Cost $9.53 Unrealized —

— CELATOR PHARMACEUTICALS INC 3.7%

Value $10.48M Shares 950,000 Est. Cost $11.03 Unrealized —

GLPG GALAPAGOS NV 3.6%

Value $10.32M Shares 246,691 Est. Cost $56.11 Unrealized —

KURA KURA ONCOLOGY INC 3.5%

Value $9.984M Shares 2,465,286 Est. Cost $10.42 Unrealized -54.5%

COLL COLLEGIUM PHARMACEUTICAL INC 3.0%

Value $8.587M Shares 473,123 Est. Cost $17.31 Unrealized +5.0%

— ACCELERON PHARMA INC 2.5%

Value $7.133M Shares 270,289 Est. Cost $26.39 Unrealized —

— AIMMUNE THERAPEUTICS INC 2.5%

Value $7.07M Shares 521,366 Est. Cost $13.56 Unrealized —

ENTA ENANTA PHARMACEUTICALS INC 2.5%

Value $7.06M Shares 240,383 Est. Cost $27.84 Unrealized 0.0%

— KITE PHARMA INC 2.4%

Value $6.887M Shares 150,000 Est. Cost $57.67 Unrealized —

SNDX SYNDAX PHARMACEUTICALS INC 2.4%

Value $6.804M Shares 510,829 Est. Cost $12.54 Unrealized 0.0%

— NABRIVA THERAPTCS AG 2.2%

Value $6.342M Shares 707,817 Est. Cost $9.50 Unrealized —

— FLEX PHARMA INC 2.2%

Value $6.318M Shares 575,925 Est. Cost $19.13 Unrealized —

— KINDRED BIOSCIENCES INC 1.7%

Value $4.943M Shares 1,432,765 Est. Cost $7.10 Unrealized —

— LOXO ONCOLOGY INC 1.4%

Value $4.109M Shares 150,308 Est. Cost $27.34 Unrealized —

— IRONWOOD PHARMACEUTICALS INC 1.1%

Value $3.282M Shares 300,000 Est. Cost — Unrealized —

— EIGER BIOPHARMACEUTICALS INC 1.1%

Value $3.179M Shares 189,545 Est. Cost $16.77 Unrealized —

EDIT EDITAS MEDICINE INC 1.1%

Value $3.037M Shares 87,921 Est. Cost $26.29 Unrealized 0.0%

— IMMUNOGEN INC 0.9%

Value $2.552M Shares 299,500 Est. Cost — Unrealized —

— CYTOKINETICS INC 0.6%

Value $1.763M Shares 250,000 Est. Cost — Unrealized —

— FORWARD PHARMA A/S 0.6%

Value $1.649M Shares 97,024 Est. Cost $23.61 Unrealized —

— ARRAY BIOPHARMA INC 0.5%

Value $1.534M Shares 520,000 Est. Cost — Unrealized —

— AKARI THERAPEUTICS PLC 0.5%

Value $1.292M Shares 92,303 Est. Cost $24.00 Unrealized —

— TARGACEPT INC 0.2%

Value $669K Shares 669,166 Est. Cost $1.00 Unrealized —

ONC BEIGENE LTD 0.2%

Value $462K Shares 15,766 Est. Cost $29.30 Unrealized —

— GLOBAL BLOOD THERAPEUTICS INC 0.2%

Value $445K Shares 28,032 Est. Cost $15.87 Unrealized —

— ATYR PHARMA INC 0.1%

Value $295K Shares 74,959 Est. Cost $18.52 Unrealized —

— SPARK THERAPEUTICS INC 0.1%

Value $257K Shares 8,700 Est. Cost $29.54 Unrealized —

— ZAFGEN INC 0.0%

Value $67,000 Shares 10,000 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
IRWD	IRONWOOD PHARMACEUTICALS INC	2,061,417	$22.55M	7.9%	$8.81	-6.4%	COM	46333X108
—	FIVE PRIME THERAPEUTICS INC	500,757	$20.35M	7.1%	$36.09	—	COM	33830X104
—	EPIZYME INC	1,598,900	$19.38M	6.8%	$15.17	—	COM	29428V104
—	FIBROGEN INC	863,745	$18.39M	6.4%	$24.72	—	COM	31572Q808
—	ARRAY BIOPHARMA INC	22,534,000	$18.14M	6.3%	$0.81	—	NOTE	04269XAA3
—	RETROPHIN INC	1,225,084	$16.73M	5.8%	$21.12	—	COM	761299106
—	SPDR SERIES TRUST S&P BIOTECH	297,200	$15.35M	5.4%	—	—	Call	78464A900
CYTK	CYTOKINETICS INC	2,052,800	$14.47M	5.1%	$9.04	-19.1%	COM	23282W605
—	GILEAD SCIENCES INC	150,000	$13.78M	4.8%	—	—	Call	375558903
—	ASSEMBLY BIOSCIENCES INC	2,098,302	$10.53M	3.7%	$9.53	—	COM	045396108
—	CELATOR PHARMACEUTICALS INC	950,000	$10.48M	3.7%	$11.03	—	COM	15089R102
GLPG	GALAPAGOS NV	246,691	$10.32M	3.6%	$56.11	—	SPONSORED ADR	36315X101
KURA	KURA ONCOLOGY INC	2,465,286	$9.984M	3.5%	$10.42	-54.5%	COM	50127T109
COLL	COLLEGIUM PHARMACEUTICAL INC	473,123	$8.587M	3.0%	$17.31	+5.0%	COM	19459J104
—	ACCELERON PHARMA INC	270,289	$7.133M	2.5%	$26.39	—	COM	00434H108
—	AIMMUNE THERAPEUTICS INC	521,366	$7.07M	2.5%	$13.56	—	COM	00900T107
ENTA	ENANTA PHARMACEUTICALS INC	240,383	$7.06M	2.5%	$27.84	0.0%	COM	29251M106
—	KITE PHARMA INC	150,000	$6.887M	2.4%	$57.67	—	COM	49803L109
SNDX	SYNDAX PHARMACEUTICALS INC	510,829	$6.804M	2.4%	$12.54	0.0%	COM	87164F105
—	NABRIVA THERAPTCS AG	707,817	$6.342M	2.2%	$9.50	—	SPONSORED ADR	62957M104
—	FLEX PHARMA INC	575,925	$6.318M	2.2%	$19.13	—	COM	33938A105
—	KINDRED BIOSCIENCES INC	1,432,765	$4.943M	1.7%	$7.10	—	COM	494577109
—	LOXO ONCOLOGY INC	150,308	$4.109M	1.4%	$27.34	—	COM	548862101
—	IRONWOOD PHARMACEUTICALS INC	300,000	$3.282M	1.1%	—	—	Call	46333X908
—	EIGER BIOPHARMACEUTICALS INC	189,545	$3.179M	1.1%	$16.77	—	COM	28249U105
EDIT	EDITAS MEDICINE INC	87,921	$3.037M	1.1%	$26.29	0.0%	COM	28106W103
—	IMMUNOGEN INC	299,500	$2.552M	0.9%	—	—	Call	45253H901
—	CYTOKINETICS INC	250,000	$1.763M	0.6%	—	—	Call	23282W905
—	FORWARD PHARMA A/S	97,024	$1.649M	0.6%	$23.61	—	SPONSORED ADR	34986J105
—	ARRAY BIOPHARMA INC	520,000	$1.534M	0.5%	—	—	Call	04269X905
—	AKARI THERAPEUTICS PLC	92,303	$1.292M	0.5%	$24.00	—	SPONSORED ADR	00972G108
—	TARGACEPT INC	669,166	$669K	0.2%	$1.00	—	NOTE	87611RAA6
ONC	BEIGENE LTD	15,766	$462K	0.2%	$29.30	—	SPONSORED ADR	07725L102
—	GLOBAL BLOOD THERAPEUTICS INC	28,032	$445K	0.2%	$15.87	—	COM	37890U108
—	ATYR PHARMA INC	74,959	$295K	0.1%	$18.52	—	COM	002120103
—	SPARK THERAPEUTICS INC	8,700	$257K	0.1%	$29.54	—	COM	84652J103
—	ZAFGEN INC	10,000	$67,000	0.0%	—	—	Call	98885E903