Sio Capital Management, LLC Hedge Fund

Location: New York, NY

CIK: 0001482416 · Show all filings

Period: Q4 2022 (← Previous) (Next →)

Filing Date: Feb 13, 2023

Total Value: $270M (100.0% shares, 0.0% debt)

Holdings (46)

— PROMETHEUS BIOSCIENCES INC 23.4%

Value $63.16M Shares 574,200 Est. Cost — Unrealized —

— MEDICUS SCIENCES ACQUISITION 8.7%

Value $23.39M Shares 2,323,000 Est. Cost $9.72 Unrealized —

BCYC BICYCLE THERAPEUTICS PLC 7.5%

Value $20.23M Shares 683,425 Est. Cost $20.16 Unrealized —

CI CIGNA CORP 6.4%

Value $17.43M Shares 52,611 Est. Cost $187.09 Unrealized +59.7%

OGN ORGANON & CO 6.1%

Value $16.42M Shares 587,836 Est. Cost $29.18 Unrealized -24.7%

UTHR UNITED THERAPEUTICS CORP 5.7%

Value $15.28M Shares 54,959 Est. Cost $165.91 Unrealized +52.2%

DGX QUEST DIAGNOSTICS INC 5.3%

Value $14.39M Shares 92,000 Est. Cost — Unrealized —

COR AMERISOURCEBERGEN CORP 5.2%

Value $13.99M Shares 84,399 Est. Cost $135.64 Unrealized +13.1%

MDT MEDTRONIC PLC 3.7%

Value $9.948M Shares 128,000 Est. Cost $73.46 Unrealized 0.0%

STAA STAAR SURGICAL CO 2.8%

Value $7.627M Shares 157,129 Est. Cost $62.72 Unrealized 0.0%

ICLR ICON PLC 2.4%

Value $6.601M Shares 33,983 Est. Cost $198.26 Unrealized 0.0%

INGN INOGEN INC 2.1%

Value $5.651M Shares 286,692 Est. Cost $31.10 Unrealized -30.8%

AVTR AVANTOR INC 1.9%

Value $5.272M Shares 250,000 Est. Cost $20.70 Unrealized 0.0%

— HESKA CORP 1.9%

Value $5.241M Shares 84,309 Est. Cost $62.16 Unrealized —

PTGX PROTAGONIST THERAPEUTICS INC 1.8%

Value $4.742M Shares 434,635 Est. Cost $8.44 Unrealized 0.0%

NVAX NOVAVAX INC 1.3%

Value $3.495M Shares 340,000 Est. Cost $17.65 Unrealized 0.0%

— CYMABAY THERAPEUTICS INC 1.3%

Value $3.484M Shares 555,610 Est. Cost $3.37 Unrealized —

PHVS PHARVARIS NV 1.2%

Value $3.206M Shares 285,000 Est. Cost $5.25 Unrealized 0.0%

— MERRIMACK PHARMACEUTICALS INC 1.1%

Value $2.865M Shares 250,000 Est. Cost $11.46 Unrealized —

— REATA PHARMACEUTICALS INC 0.9%

Value $2.545M Shares 67,000 Est. Cost — Unrealized —

— HEALTH SCIENCES ACQUISITIONS CORP 2 0.9%

Value $2.495M Shares 250,000 Est. Cost $11.00 Unrealized —

— EUCRATES BIOMEDICAL ACQUISITION CORP. 0.9%

Value $2.482M Shares 248,674 Est. Cost $10.66 Unrealized —

— CTI BIOPHARMA CORP 0.7%

Value $1.983M Shares 330,000 Est. Cost $6.01 Unrealized —

— IVERIC BIO INC 0.7%

Value $1.85M Shares 86,400 Est. Cost — Unrealized —

— X4 PHARMACEUTICALS INC 0.7%

Value $1.813M Shares 1,825,963 Est. Cost $2.60 Unrealized —

MODD MODULAR MEDICAL INC 0.5%

Value $1.379M Shares 689,352 Est. Cost $4.31 Unrealized -30.1%

— MERUS NV 0.5%

Value $1.361M Shares 87,953 Est. Cost $31.80 Unrealized —

— AEGLEA BIO THERAPEUTICS INC 0.5%

Value $1.352M Shares 3,004,959 Est. Cost $1.46 Unrealized —

SVRA SAVARA INC 0.5%

Value $1.343M Shares 866,448 Est. Cost $1.21 Unrealized +13.1%

IDYA IDEAYA BIOSCIENCES INC 0.5%

Value $1.272M Shares 70,000 Est. Cost $12.99 Unrealized +29.5%

TYRA TYRA BIOSCIENCES INC 0.4%

Value $1.156M Shares 152,159 Est. Cost $10.81 Unrealized -34.6%

— MOLECULIN BIOTECH INC 0.4%

Value $1.099M Shares 1,036,853 Est. Cost $4.03 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 0.4%

Value $1.007M Shares 136,325 Est. Cost $11.29 Unrealized -13.7%

RLMD RELMADA THERAPEUTICS INC 0.3%

Value $822K Shares 235,600 Est. Cost $8.78 Unrealized 0.0%

RLMD RELMADA THERAPEUTICS INC 0.3%

Value $822K Shares 235,500 Est. Cost $8.78 Unrealized 0.0%

— FUSION PHARMACEUTICALS INC 0.3%

Value $820K Shares 260,448 Est. Cost $11.22 Unrealized —

— CONNECT BIOPHARMA HOLDINGS LTD 0.2%

Value $519K Shares 597,678 Est. Cost $3.02 Unrealized —

— SIENTRA INC 0.2%

Value $517K Shares 2,550,000 Est. Cost $0.20 Unrealized —

— ASLAN PHARMACEUTICALS LTD 0.2%

Value $457K Shares 1,270,758 Est. Cost $1.92 Unrealized —

— ELEVATION ONCOLOGY INC 0.1%

Value $342K Shares 359,731 Est. Cost $4.95 Unrealized —

— NEXTCURE INC 0.1%

Value $183K Shares 130,000 Est. Cost $6.00 Unrealized —

— CAREMAX INC 0.0%

Value $119K Shares 43,549 Est. Cost $8.24 Unrealized —

— VINCERX PHARMA INC 0.0%

Value $104K Shares 102,049 Est. Cost $18.89 Unrealized —

NYXH NYXOAH SA 0.0%

Value $80,389 Shares 16,110 Est. Cost $31.50 Unrealized -81.9%

HUMA HUMACYTE INC 0.0%

Value $20,314 Shares 49,998 Est. Cost $3.04 Unrealized 0.0%

— NEOLEUKIN THERAPEUTICS INC 0.0%

Value $19,501 Shares 38,312 Est. Cost $12.32 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	PROMETHEUS BIOSCIENCES INC	574,200	$63.16M	23.4%	—	—	Put	74349U108
—	MEDICUS SCIENCES ACQUISITION	2,323,000	$23.39M	8.7%	$9.72	—	CL A SHS	G5960S108
BCYC	BICYCLE THERAPEUTICS PLC	683,425	$20.23M	7.5%	$20.16	—	SPONSORED ADS	088786108
CI	CIGNA CORP	52,611	$17.43M	6.4%	$187.09	+59.7%	COM	125523100
OGN	ORGANON & CO	587,836	$16.42M	6.1%	$29.18	-24.7%	COMMON STOCK	68622V106
UTHR	UNITED THERAPEUTICS CORP	54,959	$15.28M	5.7%	$165.91	+52.2%	COM	91307C102
DGX	QUEST DIAGNOSTICS INC	92,000	$14.39M	5.3%	—	—	Put	74834L100
COR	AMERISOURCEBERGEN CORP	84,399	$13.99M	5.2%	$135.64	+13.1%	COM	03073E105
MDT	MEDTRONIC PLC	128,000	$9.948M	3.7%	$73.46	0.0%	SHS	G5960L103
STAA	STAAR SURGICAL CO	157,129	$7.627M	2.8%	$62.72	0.0%	COM PAR $0.01	852312305
ICLR	ICON PLC	33,983	$6.601M	2.4%	$198.26	0.0%	SHS	G4705A100
INGN	INOGEN INC	286,692	$5.651M	2.1%	$31.10	-30.8%	COM	45780L104
AVTR	AVANTOR INC	250,000	$5.272M	1.9%	$20.70	0.0%	COM	05352A100
—	HESKA CORP	84,309	$5.241M	1.9%	$62.16	—	COM RESTRC NEW	42805E306
PTGX	PROTAGONIST THERAPEUTICS INC	434,635	$4.742M	1.8%	$8.44	0.0%	COM	74366E102
NVAX	NOVAVAX INC	340,000	$3.495M	1.3%	$17.65	0.0%	COM NEW	670002401
—	CYMABAY THERAPEUTICS INC	555,610	$3.484M	1.3%	$3.37	—	COM	23257D103
PHVS	PHARVARIS NV	285,000	$3.206M	1.2%	$5.25	0.0%	COM	N69605108
—	MERRIMACK PHARMACEUTICALS INC	250,000	$2.865M	1.1%	$11.46	—	COM NEW	590328209
—	REATA PHARMACEUTICALS INC	67,000	$2.545M	0.9%	—	—	Put	75615P103
—	HEALTH SCIENCES ACQUISITIONS CORP 2	250,000	$2.495M	0.9%	$11.00	—	ORD SHS	G4411D109
—	EUCRATES BIOMEDICAL ACQUISITION CORP.	248,674	$2.482M	0.9%	$10.66	—	UNIT 10/23/2027	G3141W114
—	CTI BIOPHARMA CORP	330,000	$1.983M	0.7%	$6.01	—	COM	12648L601
—	IVERIC BIO INC	86,400	$1.85M	0.7%	—	—	Put	46583P102
—	X4 PHARMACEUTICALS INC	1,825,963	$1.813M	0.7%	$2.60	—	COM	98420X103
MODD	MODULAR MEDICAL INC	689,352	$1.379M	0.5%	$4.31	-30.1%	COM NEW	60785L207
—	MERUS NV	87,953	$1.361M	0.5%	$31.80	—	COM	N5749R100
—	AEGLEA BIO THERAPEUTICS INC	3,004,959	$1.352M	0.5%	$1.46	—	COM	00773J103
SVRA	SAVARA INC	866,448	$1.343M	0.5%	$1.21	+13.1%	COM	805111101
IDYA	IDEAYA BIOSCIENCES INC	70,000	$1.272M	0.5%	$12.99	+29.5%	COM	45166A102
TYRA	TYRA BIOSCIENCES INC	152,159	$1.156M	0.4%	$10.81	-34.6%	COM	90240B106
—	MOLECULIN BIOTECH INC	1,036,853	$1.099M	0.4%	$4.03	—	COM	60855D200
VNDA	VANDA PHARMACEUTICALS INC	136,325	$1.007M	0.4%	$11.29	-13.7%	COM	921659108
RLMD	RELMADA THERAPEUTICS INC	235,600	$822K	0.3%	$8.78	0.0%	Put	75955J402
RLMD	RELMADA THERAPEUTICS INC	235,500	$822K	0.3%	$8.78	0.0%	COM	75955J402
—	FUSION PHARMACEUTICALS INC	260,448	$820K	0.3%	$11.22	—	COM	36118A100
—	CONNECT BIOPHARMA HOLDINGS LTD	597,678	$519K	0.2%	$3.02	—	ADS	207523101
—	SIENTRA INC	2,550,000	$517K	0.2%	$0.20	—	COM	82621J105
—	ASLAN PHARMACEUTICALS LTD	1,270,758	$457K	0.2%	$1.92	—	ADS	04522R101
—	ELEVATION ONCOLOGY INC	359,731	$342K	0.1%	$4.95	—	COM	28623U101
—	NEXTCURE INC	130,000	$183K	0.1%	$6.00	—	COM	65343E108
—	CAREMAX INC	43,549	$119K	0.0%	$8.24	—	COM CL A	14171W103
—	VINCERX PHARMA INC	102,049	$104K	0.0%	$18.89	—	COM NEW	92731L106
NYXH	NYXOAH SA	16,110	$80,389	0.0%	$31.50	-81.9%	SHS	B6S7WD106
HUMA	HUMACYTE INC	49,998	$20,314	0.0%	$3.04	0.0%	*W EXP 08/27/202	44486Q103
—	NEOLEUKIN THERAPEUTICS INC	38,312	$19,501	0.0%	$12.32	—	COM	64049K104