Ghost Tree Capital, LLC Hedge Fund

CIK: 0001595851 · Show all filings

Period: Q1 2019 (← Previous) (Next →)

Filing Date: Apr 9, 2020

Total Value: $383M (100.0% shares, 0.0% debt)

Holdings (39)

ASND ASCENDIS PHARMA A S 11.8%

Value $45.31M Shares 385,000 Share Price $117.70 Est. Cost/Share $95.44 Unrealized @ Report Date —

ACAD ACADIA PHARMACEUTICALS INC 6.3%

Value $24.16M Shares 900,000 Share Price $26.85 * Est. Cost/Share $23.61 Unrealized @ Report Date -1.1%

ASND ASCENDIS PHARMA A S 5.7%

Value $21.77M Shares 185,000 Share Price $117.70 Est. Cost/Share $95.44 Unrealized @ Report Date —

— BLUEPRINT MEDICINES CORP 5.0%

Value $19.21M Shares 240,000 Share Price $80.05 Est. Cost/Share $80.05 Unrealized @ Report Date —

FOLD AMICUS THERAPEUTICS INC 4.6%

Value $17.68M Shares 1,300,000 Share Price $13.60 * Est. Cost/Share $11.60 Unrealized @ Report Date +5.3%

— GLOBAL BLOOD THERAPEUTICS IN 4.1%

Value $15.88M Shares 300,000 Share Price $52.93 Est. Cost/Share $49.14 Unrealized @ Report Date —

— IMMUNOMEDICS INC 4.0%

Value $15.37M Shares 800,000 Share Price $19.21 Est. Cost/Share $8.35 Unrealized @ Report Date —

VRTX VERTEX PHARMACEUTICALS INC 3.8%

Value $14.72M Shares 80,000 Share Price $183.95 Est. Cost/Share $173.27 Unrealized @ Report Date +6.6%

ALNY ALNYLAM PHARMACEUTICALS INC 3.7%

Value $14.02M Shares 150,000 Share Price $93.45 * Est. Cost/Share $87.26 Unrealized @ Report Date -4.2%

— SAGE THERAPEUTICS INC 3.1%

Value $11.93M Shares 75,000 Share Price $159.05 Est. Cost/Share $158.27 Unrealized @ Report Date —

KALV KALVISTA PHARMACEUTICALS INC 3.0%

Value $11.45M Shares 400,000 Share Price $28.62 * Est. Cost/Share $16.62 Unrealized @ Report Date +30.5%

— RETROPHIN INC 3.0%

Value $11.31M Shares 500,000 Share Price $22.63 Est. Cost/Share $26.90 Unrealized @ Report Date —

— MIRATI THERAPEUTICS INC 2.9%

Value $10.99M Shares 150,000 Share Price $73.30 Est. Cost/Share $33.00 Unrealized @ Report Date —

IOVA IOVANCE BIOTHERAPEUTICS INC 2.9%

Value $10.94M Shares 1,150,000 Share Price $9.51 * Est. Cost/Share $9.65 Unrealized @ Report Date +0.6%

RCKT ROCKET PHARMACEUTICALS INC 2.7%

Value $10.52M Shares 600,000 Share Price $17.54 * Est. Cost/Share $16.85 Unrealized @ Report Date -6.3%

— CYMABAY THERAPEUTICS INC 2.6%

Value $9.96M Shares 750,000 Share Price $13.28 Est. Cost/Share $13.28 Unrealized @ Report Date —

— BIOHAVEN PHARMACTL HLDG CO L 2.4%

Value $9.007M Shares 175,000 Share Price $51.47 Est. Cost/Share $37.40 Unrealized @ Report Date —

PTGX PROTAGONIST THERAPEUTICS INC 2.3%

Value $8.799M Shares 700,000 Share Price $12.57 * Est. Cost/Share $8.83 Unrealized @ Report Date 0.0%

FXF INVESCO CURNCYSHS SWISS FRAN 2.2%

Value $8.574M Shares 91,800 Share Price $93.40 Est. Cost/Share $94.55 Unrealized @ Report Date —

ANAB ANAPTYSBIO INC 2.2%

Value $8.401M Shares 115,000 Share Price $73.05 * Est. Cost/Share $80.01 Unrealized @ Report Date -13.7%

— MOMENTA PHARMACEUTICALS INC 1.9%

Value $7.265M Shares 500,000 Share Price $14.53 Est. Cost/Share $12.26 Unrealized @ Report Date —

— AUDENTES THERAPEUTICS INC 1.8%

Value $6.829M Shares 175,000 Share Price $39.02 Est. Cost/Share $21.32 Unrealized @ Report Date —

— RA PHARMACEUTICALS INC 1.8%

Value $6.72M Shares 300,000 Share Price $22.40 Est. Cost/Share $22.40 Unrealized @ Report Date —

— DBV TECHNOLOGIES S A 1.7%

Value $6.554M Shares 850,000 Share Price $7.71 Est. Cost/Share $7.71 Unrealized @ Report Date —

— EPIZYME INC 1.6%

Value $6.195M Shares 500,000 Share Price $12.39 Est. Cost/Share $12.39 Unrealized @ Report Date —

CHRS COHERUS BIOSCIENCES INC 1.6%

Value $6.138M Shares 450,000 Share Price $13.64 * Est. Cost/Share $13.34 Unrealized @ Report Date 0.0%

— TRICIDA INC 1.5%

Value $5.793M Shares 150,000 Share Price $38.62 Est. Cost/Share $30.07 Unrealized @ Report Date —

— KADMON HLDGS INC 1.4%

Value $5.544M Shares 2,100,000 Share Price $2.64 Est. Cost/Share $3.79 Unrealized @ Report Date —

VRAYQ VIEWRAY INC 1.4%

Value $5.543M Shares 750,000 Share Price $7.39 * Est. Cost/Share $6.99 Unrealized @ Report Date +10.4%

— ORCHARD THERAPEUTICS PLC 1.4%

Value $5.364M Shares 300,000 Share Price $17.88 Est. Cost/Share $15.73 Unrealized @ Report Date —

AXSM AXSOME THERAPEUTICS INC 1.2%

Value $4.411M Shares 310,000 Share Price $14.23 * Est. Cost/Share $9.29 Unrealized @ Report Date 0.0%

BCRX BIOCRYST PHARMACEUTICALS 1.1%

Value $4.07M Shares 500,000 Share Price $8.14 * Est. Cost/Share $6.72 Unrealized @ Report Date +27.5%

— CHIASMA INC 1.0%

Value $3.64M Shares 700,000 Share Price $5.20 Est. Cost/Share $5.20 Unrealized @ Report Date —

ARVN ARVINAS INC 0.7%

Value $2.583M Shares 175,000 Share Price $14.76 * Est. Cost/Share $16.46 Unrealized @ Report Date +7.8%

— OBSEVA SA 0.7%

Value $2.558M Shares 200,000 Share Price $12.79 Est. Cost/Share $11.87 Unrealized @ Report Date —

— GENOCEA BIOSCIENCES INC 0.3%

Value $1.18M Shares 2,000,000 Share Price $0.59 Est. Cost/Share $0.86 Unrealized @ Report Date —

— SOLID BIOSCIENCES INC 0.2%

Value $920K Shares 100,000 Share Price $9.20 Est. Cost/Share $9.20 Unrealized @ Report Date —

— CATALYST BIOSCIENCES INC 0.2%

Value $811K Shares 100,000 Share Price $8.11 Est. Cost/Share $25.80 Unrealized @ Report Date —

— FIBROGEN INC 0.2%

Value $625K Shares 11,500 Share Price $54.35 Est. Cost/Share $54.35 Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
ASND	ASCENDIS PHARMA A S	385,000	$45.31M	11.8%	$117.70	$95.44	—	SPONSORED ADR	04351P101
ACAD	ACADIA PHARMACEUTICALS INC	900,000	$24.16M	6.3%	$26.85 *	$23.61	-1.1%	COM	004225108
ASND	ASCENDIS PHARMA A S	185,000	$21.77M	5.7%	$117.70	$95.44	—	Put	04351P101
—	BLUEPRINT MEDICINES CORP	240,000	$19.21M	5.0%	$80.05	$80.05	—	COM	09627Y109
FOLD	AMICUS THERAPEUTICS INC	1,300,000	$17.68M	4.6%	$13.60 *	$11.60	+5.3%	COM	03152W109
—	GLOBAL BLOOD THERAPEUTICS IN	300,000	$15.88M	4.1%	$52.93	$49.14	—	COM	37890U108
—	IMMUNOMEDICS INC	800,000	$15.37M	4.0%	$19.21	$8.35	—	COM	452907108
VRTX	VERTEX PHARMACEUTICALS INC	80,000	$14.72M	3.8%	$183.95	$173.27	+6.6%	COM	92532F100
ALNY	ALNYLAM PHARMACEUTICALS INC	150,000	$14.02M	3.7%	$93.45 *	$87.26	-4.2%	COM	02043Q107
—	SAGE THERAPEUTICS INC	75,000	$11.93M	3.1%	$159.05	$158.27	—	COM	78667J108
KALV	KALVISTA PHARMACEUTICALS INC	400,000	$11.45M	3.0%	$28.62 *	$16.62	+30.5%	COM	483497103
—	RETROPHIN INC	500,000	$11.31M	3.0%	$22.63	$26.90	—	COM	761299106
—	MIRATI THERAPEUTICS INC	150,000	$10.99M	2.9%	$73.30	$33.00	—	COM	60468T105
IOVA	IOVANCE BIOTHERAPEUTICS INC	1,150,000	$10.94M	2.9%	$9.51 *	$9.65	+0.6%	COM	462260100
RCKT	ROCKET PHARMACEUTICALS INC	600,000	$10.52M	2.7%	$17.54 *	$16.85	-6.3%	COM	77313F106
—	CYMABAY THERAPEUTICS INC	750,000	$9.96M	2.6%	$13.28	$13.28	—	COM	23257D103
—	BIOHAVEN PHARMACTL HLDG CO L	175,000	$9.007M	2.4%	$51.47	$37.40	—	Call	G11196105
PTGX	PROTAGONIST THERAPEUTICS INC	700,000	$8.799M	2.3%	$12.57 *	$8.83	0.0%	COM	74366E102
FXF	INVESCO CURNCYSHS SWISS FRAN	91,800	$8.574M	2.2%	$93.40	$94.55	—	SWISS FRANC	46138R108
ANAB	ANAPTYSBIO INC	115,000	$8.401M	2.2%	$73.05 *	$80.01	-13.7%	COM	032724106
—	MOMENTA PHARMACEUTICALS INC	500,000	$7.265M	1.9%	$14.53	$12.26	—	COM	60877T100
—	AUDENTES THERAPEUTICS INC	175,000	$6.829M	1.8%	$39.02	$21.32	—	COM	05070R104
—	RA PHARMACEUTICALS INC	300,000	$6.72M	1.8%	$22.40	$22.40	—	COM	74933V108
—	DBV TECHNOLOGIES S A	850,000	$6.554M	1.7%	$7.71	$7.71	—	SPONSORED ADR	23306J101
—	EPIZYME INC	500,000	$6.195M	1.6%	$12.39	$12.39	—	COM	29428V104
CHRS	COHERUS BIOSCIENCES INC	450,000	$6.138M	1.6%	$13.64 *	$13.34	0.0%	COM	19249H103
—	TRICIDA INC	150,000	$5.793M	1.5%	$38.62	$30.07	—	COM	89610F101
—	KADMON HLDGS INC	2,100,000	$5.544M	1.4%	$2.64	$3.79	—	COM	48283N106
VRAYQ	VIEWRAY INC	750,000	$5.543M	1.4%	$7.39 *	$6.99	+10.4%	COM	92672L107
—	ORCHARD THERAPEUTICS PLC	300,000	$5.364M	1.4%	$17.88	$15.73	—	ADS	68570P101
AXSM	AXSOME THERAPEUTICS INC	310,000	$4.411M	1.2%	$14.23 *	$9.29	0.0%	COM	05464T104
BCRX	BIOCRYST PHARMACEUTICALS	500,000	$4.07M	1.1%	$8.14 *	$6.72	+27.5%	COM	09058V103
—	CHIASMA INC	700,000	$3.64M	1.0%	$5.20	$5.20	—	COM	16706W102
ARVN	ARVINAS INC	175,000	$2.583M	0.7%	$14.76 *	$16.46	+7.8%	COM	04335A105
—	OBSEVA SA	200,000	$2.558M	0.7%	$12.79	$11.87	—	COM	H5861P103
—	GENOCEA BIOSCIENCES INC	2,000,000	$1.18M	0.3%	$0.59	$0.86	—	COM	372427104
—	SOLID BIOSCIENCES INC	100,000	$920K	0.2%	$9.20	$9.20	—	COM	83422E105
—	CATALYST BIOSCIENCES INC	100,000	$811K	0.2%	$8.11	$25.80	—	COM NEW	14888D208
—	FIBROGEN INC	11,500	$625K	0.2%	$54.35	$54.35	—	COM	31572Q808