Ghost Tree Capital, LLC Hedge Fund

CIK: 0001595851 · Show all filings

Period: Q1 2022 (← Previous) (Next →)

Filing Date: May 16, 2022

Total Value: $461M (100.0% shares, 0.0% debt)

Holdings (42)

SPY SPDR S&P 500 ETF TR 49.0%

Value $226M Shares 500,000 Est. Cost — Unrealized —

XBI SPDR SER TR 5.9%

Value $26.96M Shares 300,000 Est. Cost — Unrealized —

ASND ASCENDIS PHARMA A/S 3.6%

Value $16.43M Shares 140,000 Est. Cost $131.68 Unrealized —

COGT COGENT BIOSCIENCES INC 2.8%

Value $12.73M Shares 1,700,000 Est. Cost $10.34 Unrealized -32.7%

APLS APELLIS PHARMACEUTICALS INC 2.8%

Value $12.7M Shares 250,000 Est. Cost $49.72 Unrealized -11.2%

— MERUS N V 2.3%

Value $10.58M Shares 400,000 Est. Cost $29.12 Unrealized —

FOLD AMICUS THERAPEUTICS INC 2.3%

Value $10.42M Shares 1,100,000 Est. Cost $11.01 Unrealized -14.8%

— SIERRA ONCOLOGY INC 2.3%

Value $10.42M Shares 325,000 Est. Cost $20.61 Unrealized —

CLDX CELLDEX THERAPEUTICS INC NEW 2.2%

Value $10.22M Shares 300,000 Est. Cost $28.96 Unrealized +10.4%

VRDN VIRIDIAN THERAPEUTICS INC 1.9%

Value $8.624M Shares 466,403 Est. Cost $18.53 Unrealized +3.7%

— KARUNA THERAPEUTICS INC 1.7%

Value $7.607M Shares 60,000 Est. Cost $126.78 Unrealized —

— IVERIC BIO INC 1.6%

Value $7.574M Shares 450,000 Est. Cost $7.44 Unrealized —

ARVN ARVINAS INC 1.6%

Value $7.403M Shares 110,000 Est. Cost $28.07 Unrealized +142.8%

PCVX VAXCYTE INC 1.6%

Value $7.245M Shares 300,000 Est. Cost $21.73 Unrealized +0.6%

— KEZAR LIFE SCIENCES INC 1.4%

Value $6.648M Shares 400,000 Est. Cost $16.68 Unrealized —

AXSM AXSOME THERAPEUTICS INC 1.3%

Value $6.209M Shares 150,000 Est. Cost $31.00 Unrealized 0.0%

— CTI BIOPHARMA CORP 1.3%

Value $6.071M Shares 1,300,000 Est. Cost $2.98 Unrealized —

BCRX BIOCRYST PHARMACEUTICALS INC 1.2%

Value $5.691M Shares 350,000 Est. Cost $16.04 Unrealized 0.0%

— RAPT THERAPEUTICS INC 1.2%

Value $5.498M Shares 250,000 Est. Cost $33.20 Unrealized —

BCYC BICYCLE THERAPEUTICS PLC 1.0%

Value $4.388M Shares 100,000 Est. Cost $43.88 Unrealized —

AXSM AXSOME THERAPEUTICS INC 0.8%

Value $3.911M Shares 94,500 Est. Cost $31.00 Unrealized 0.0%

SNDX SYNDAX PHARMACEUTICALS INC 0.8%

Value $3.911M Shares 225,000 Est. Cost $18.21 Unrealized -7.5%

SRPT SAREPTA THERAPEUTICS INC 0.8%

Value $3.906M Shares 50,000 Est. Cost $85.49 Unrealized -10.4%

— VERONA PHARMA PLC 0.8%

Value $3.743M Shares 750,000 Est. Cost $6.53 Unrealized —

ZNTL ZENTALIS PHARMACEUTICALS INC 0.8%

Value $3.691M Shares 80,000 Est. Cost $61.38 Unrealized -12.1%

DSGN DESIGN THERAPEUTICS INC 0.7%

Value $3.23M Shares 200,000 Est. Cost $16.57 Unrealized -7.5%

RCKT ROCKET PHARMACEUTICALS INC 0.7%

Value $3.172M Shares 200,000 Est. Cost $29.94 Unrealized -42.3%

XENE XENON PHARMACEUTICALS INC 0.7%

Value $3.057M Shares 100,000 Est. Cost $13.60 Unrealized +120.1%

RLMD RELMADA THERAPEUTICS INC 0.6%

Value $2.699M Shares 100,000 Est. Cost $26.77 Unrealized -22.7%

WHWK AADI BIOSCIENCE INC 0.6%

Value $2.546M Shares 150,000 Est. Cost $25.11 Unrealized -23.7%

ACRS ACLARIS THERAPEUTICS INC 0.5%

Value $2.155M Shares 125,000 Est. Cost $6.81 Unrealized +100.4%

TARS TARSUS PHARMACEUTICALS INC 0.4%

Value $2.018M Shares 120,000 Est. Cost $31.23 Unrealized -40.6%

— 9 METERS BIOPHARMA INC 0.4%

Value $1.948M Shares 3,250,000 Est. Cost $1.25 Unrealized —

CRNX CRINETICS PHARMACEUTICALS IN 0.4%

Value $1.866M Shares 85,000 Est. Cost $17.57 Unrealized +15.2%

— SATSUMA PHARMACEUTICALS INC 0.4%

Value $1.8M Shares 473,562 Est. Cost $10.24 Unrealized —

— LEAP THERAPEUTICS INC 0.4%

Value $1.739M Shares 993,714 Est. Cost $4.01 Unrealized —

— MIRATI THERAPEUTICS INC 0.4%

Value $1.644M Shares 20,000 Est. Cost $98.34 Unrealized —

— VISTAGEN THERAPEUTICS INC 0.4%

Value $1.631M Shares 1,315,154 Est. Cost $2.02 Unrealized —

— AEGLEA BIOTHERAPEUTICS INC 0.3%

Value $1.579M Shares 686,599 Est. Cost $2.30 Unrealized —

— PARDES BIOSCIENCES INC 0.1%

Value $614K Shares 85,000 Est. Cost $12.61 Unrealized —

LRMR LARIMAR THERAPEUTICS INC 0.1%

Value $405K Shares 100,000 Est. Cost $11.59 Unrealized -43.5%

PYXS PYXIS ONCOLOGY INC 0.1%

Value $303K Shares 75,000 Est. Cost $11.45 Unrealized -36.2%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
SPY	SPDR S&P 500 ETF TR	500,000	$226M	49.0%	—	—	Put	78462F103
XBI	SPDR SER TR	300,000	$26.96M	5.9%	—	—	Call	78464A870
ASND	ASCENDIS PHARMA A/S	140,000	$16.43M	3.6%	$131.68	—	SPONSORED ADR	04351P101
COGT	COGENT BIOSCIENCES INC	1,700,000	$12.73M	2.8%	$10.34	-32.7%	COM	19240Q201
APLS	APELLIS PHARMACEUTICALS INC	250,000	$12.7M	2.8%	$49.72	-11.2%	COM	03753U106
—	MERUS N V	400,000	$10.58M	2.3%	$29.12	—	COM	N5749R100
FOLD	AMICUS THERAPEUTICS INC	1,100,000	$10.42M	2.3%	$11.01	-14.8%	COM	03152W109
—	SIERRA ONCOLOGY INC	325,000	$10.42M	2.3%	$20.61	—	COM NEW	82640U404
CLDX	CELLDEX THERAPEUTICS INC NEW	300,000	$10.22M	2.2%	$28.96	+10.4%	COM NEW	15117B202
VRDN	VIRIDIAN THERAPEUTICS INC	466,403	$8.624M	1.9%	$18.53	+3.7%	COM	92790C104
—	KARUNA THERAPEUTICS INC	60,000	$7.607M	1.7%	$126.78	—	COM	48576A100
—	IVERIC BIO INC	450,000	$7.574M	1.6%	$7.44	—	COM	46583P102
ARVN	ARVINAS INC	110,000	$7.403M	1.6%	$28.07	+142.8%	COM	04335A105
PCVX	VAXCYTE INC	300,000	$7.245M	1.6%	$21.73	+0.6%	COM	92243G108
—	KEZAR LIFE SCIENCES INC	400,000	$6.648M	1.4%	$16.68	—	COM	49372L100
AXSM	AXSOME THERAPEUTICS INC	150,000	$6.209M	1.3%	$31.00	0.0%	Put	05464T104
—	CTI BIOPHARMA CORP	1,300,000	$6.071M	1.3%	$2.98	—	COM	12648L601
BCRX	BIOCRYST PHARMACEUTICALS INC	350,000	$5.691M	1.2%	$16.04	0.0%	COM	09058V103
—	RAPT THERAPEUTICS INC	250,000	$5.498M	1.2%	$33.20	—	COM	75382E109
BCYC	BICYCLE THERAPEUTICS PLC	100,000	$4.388M	1.0%	$43.88	—	SPONSORED ADS	088786108
AXSM	AXSOME THERAPEUTICS INC	94,500	$3.911M	0.8%	$31.00	0.0%	COM	05464T104
SNDX	SYNDAX PHARMACEUTICALS INC	225,000	$3.911M	0.8%	$18.21	-7.5%	COM	87164F105
SRPT	SAREPTA THERAPEUTICS INC	50,000	$3.906M	0.8%	$85.49	-10.4%	COM	803607100
—	VERONA PHARMA PLC	750,000	$3.743M	0.8%	$6.53	—	SPONSORED ADS	925050106
ZNTL	ZENTALIS PHARMACEUTICALS INC	80,000	$3.691M	0.8%	$61.38	-12.1%	COM	98943L107
DSGN	DESIGN THERAPEUTICS INC	200,000	$3.23M	0.7%	$16.57	-7.5%	COM	25056L103
RCKT	ROCKET PHARMACEUTICALS INC	200,000	$3.172M	0.7%	$29.94	-42.3%	COM	77313F106
XENE	XENON PHARMACEUTICALS INC	100,000	$3.057M	0.7%	$13.60	+120.1%	COM	98420N105
RLMD	RELMADA THERAPEUTICS INC	100,000	$2.699M	0.6%	$26.77	-22.7%	COM	75955J402
WHWK	AADI BIOSCIENCE INC	150,000	$2.546M	0.6%	$25.11	-23.7%	COM	00032Q104
ACRS	ACLARIS THERAPEUTICS INC	125,000	$2.155M	0.5%	$6.81	+100.4%	COM	00461U105
TARS	TARSUS PHARMACEUTICALS INC	120,000	$2.018M	0.4%	$31.23	-40.6%	COM	87650L103
—	9 METERS BIOPHARMA INC	3,250,000	$1.948M	0.4%	$1.25	—	COM	654405109
CRNX	CRINETICS PHARMACEUTICALS IN	85,000	$1.866M	0.4%	$17.57	+15.2%	COM	22663K107
—	SATSUMA PHARMACEUTICALS INC	473,562	$1.8M	0.4%	$10.24	—	COM	80405P107
—	LEAP THERAPEUTICS INC	993,714	$1.739M	0.4%	$4.01	—	COM	52187K101
—	MIRATI THERAPEUTICS INC	20,000	$1.644M	0.4%	$98.34	—	COM	60468T105
—	VISTAGEN THERAPEUTICS INC	1,315,154	$1.631M	0.4%	$2.02	—	COM NEW	92840H202
—	AEGLEA BIOTHERAPEUTICS INC	686,599	$1.579M	0.3%	$2.30	—	COM	00773J103
—	PARDES BIOSCIENCES INC	85,000	$614K	0.1%	$12.61	—	COM	69945Q105
LRMR	LARIMAR THERAPEUTICS INC	100,000	$405K	0.1%	$11.59	-43.5%	COM	517125100
PYXS	PYXIS ONCOLOGY INC	75,000	$303K	0.1%	$11.45	-36.2%	COMMON STOCK	747324101