Ghost Tree Capital, LLC Hedge Fund

CIK: 0001595851 · Show all filings

Period: Q2 2022 (← Previous) (Next →)

Filing Date: Aug 15, 2022

Total Value: $192M (100.0% shares, 0.0% debt)

Holdings (33)

XBI SPDR SER TR 15.5%

Value $29.71M Shares 400,000 Share Price $74.27 Est. Cost/Share — Unrealized @ Report Date —

CLDX CELLDEX THERAPEUTICS INC NEW 5.6%

Value $10.78M Shares 400,000 Share Price $26.96 * Est. Cost/Share $28.96 Unrealized @ Report Date +0.3%

FOLD AMICUS THERAPEUTICS INC 5.6%

Value $10.74M Shares 1,000,000 Share Price $10.74 * Est. Cost/Share $11.01 Unrealized @ Report Date -25.2%

APLS APELLIS PHARMACEUTICALS INC 5.3%

Value $10.18M Shares 225,000 Share Price $45.22 Est. Cost/Share $49.72 Unrealized @ Report Date -8.3%

SRPT SAREPTA THERAPEUTICS INC 5.1%

Value $9.745M Shares 130,000 Share Price $74.96 Est. Cost/Share $78.15 Unrealized @ Report Date -5.9%

AXSM AXSOME THERAPEUTICS INC 4.5%

Value $8.618M Shares 225,000 Share Price $38.30 * Est. Cost/Share $31.36 Unrealized @ Report Date +0.8%

COGT COGENT BIOSCIENCES INC 4.2%

Value $8.118M Shares 900,000 Share Price $9.02 * Est. Cost/Share $10.34 Unrealized @ Report Date -34.0%

— HORIZON THERAPEUTICS PUB L 4.2%

Value $7.976M Shares 100,000 Share Price $79.76 Est. Cost/Share $79.76 Unrealized @ Report Date —

— MIRATI THERAPEUTICS INC 3.8%

Value $7.384M Shares 110,000 Share Price $67.13 Est. Cost/Share $72.80 Unrealized @ Report Date —

PCVX VAXCYTE INC 3.7%

Value $7.072M Shares 325,000 Share Price $21.76 * Est. Cost/Share $21.83 Unrealized @ Report Date +6.0%

ASND ASCENDIS PHARMA A/S 3.6%

Value $6.972M Shares 75,000 Share Price $92.96 Est. Cost/Share $131.68 Unrealized @ Report Date —

VRDN VIRIDIAN THERAPEUTICS INC 3.6%

Value $6.942M Shares 600,000 Share Price $11.57 * Est. Cost/Share $17.40 Unrealized @ Report Date -22.8%

— SEAGEN INC 3.2%

Value $6.193M Shares 35,000 Share Price $176.94 Est. Cost/Share $176.94 Unrealized @ Report Date —

— KARUNA THERAPEUTICS INC 3.0%

Value $5.693M Shares 45,000 Share Price $126.51 Est. Cost/Share $126.78 Unrealized @ Report Date —

— MERUS N V 2.9%

Value $5.66M Shares 250,000 Share Price $22.64 Est. Cost/Share $29.12 Unrealized @ Report Date —

— IVERIC BIO INC 2.5%

Value $4.81M Shares 500,000 Share Price $9.62 Est. Cost/Share $7.65 Unrealized @ Report Date —

— CTI BIOPHARMA CORP 2.5%

Value $4.776M Shares 800,000 Share Price $5.97 Est. Cost/Share $2.98 Unrealized @ Report Date —

RLMD RELMADA THERAPEUTICS INC 2.5%

Value $4.748M Shares 250,000 Share Price $18.99 * Est. Cost/Share $23.79 Unrealized @ Report Date -8.3%

ARVN ARVINAS INC 2.4%

Value $4.63M Shares 110,000 Share Price $42.09 * Est. Cost/Share $28.07 Unrealized @ Report Date +78.7%

SNDX SYNDAX PHARMACEUTICALS INC 2.3%

Value $4.329M Shares 225,000 Share Price $19.24 * Est. Cost/Share $18.21 Unrealized @ Report Date -8.5%

DSGN DESIGN THERAPEUTICS INC 2.0%

Value $3.85M Shares 275,000 Share Price $14.00 * Est. Cost/Share $15.73 Unrealized @ Report Date -14.1%

— KEZAR LIFE SCIENCES INC 1.9%

Value $3.722M Shares 450,000 Share Price $8.27 Est. Cost/Share $15.75 Unrealized @ Report Date —

XBI SPDR SER TR 1.9%

Value $3.714M Shares 50,000 Share Price $74.28 Est. Cost/Share — Unrealized @ Report Date —

BCRX BIOCRYST PHARMACEUTICALS INC 1.8%

Value $3.439M Shares 325,000 Share Price $10.58 * Est. Cost/Share $16.04 Unrealized @ Report Date -35.7%

— RAPT THERAPEUTICS INC 1.6%

Value $3.011M Shares 165,000 Share Price $18.25 Est. Cost/Share $33.20 Unrealized @ Report Date —

— DICE THERAPEUTICS INC 1.2%

Value $2.328M Shares 150,000 Share Price $15.52 Est. Cost/Share $15.53 Unrealized @ Report Date —

WHWK AADI BIOSCIENCE INC 1.0%

Value $1.848M Shares 150,000 Share Price $12.32 * Est. Cost/Share $25.11 Unrealized @ Report Date -40.9%

TARS TARSUS PHARMACEUTICALS INC 0.9%

Value $1.752M Shares 120,000 Share Price $14.60 * Est. Cost/Share $31.23 Unrealized @ Report Date -51.9%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 0.8%

Value $1.575M Shares 300,000 Share Price $5.25 * Est. Cost/Share $6.29 Unrealized @ Report Date 0.0%

— 9 METERS BIOPHARMA INC 0.2%

Value $469K Shares 1,800,000 Share Price $0.26 Est. Cost/Share $1.25 Unrealized @ Report Date —

— AEGLEA BIOTHERAPEUTICS INC 0.2%

Value $467K Shares 925,000 Share Price $0.50 Est. Cost/Share $1.84 Unrealized @ Report Date —

— DICE THERAPEUTICS INC 0.2%

Value $466K Shares 30,000 Share Price $15.53 Est. Cost/Share $15.53 Unrealized @ Report Date —

ALNY ALNYLAM PHARMACEUTICALS INC 0.1%

Value $277K Shares 1,900 Share Price $145.79 * Est. Cost/Share $141.87 Unrealized @ Report Date 0.0%

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
XBI	SPDR SER TR	400,000	$29.71M	15.5%	$74.27	—	—	Put	78464A870
CLDX	CELLDEX THERAPEUTICS INC NEW	400,000	$10.78M	5.6%	$26.96 *	$28.96	+0.3%	Call	15117B202
FOLD	AMICUS THERAPEUTICS INC	1,000,000	$10.74M	5.6%	$10.74 *	$11.01	-25.2%	COM	03152W109
APLS	APELLIS PHARMACEUTICALS INC	225,000	$10.18M	5.3%	$45.22	$49.72	-8.3%	COM	03753U106
SRPT	SAREPTA THERAPEUTICS INC	130,000	$9.745M	5.1%	$74.96	$78.15	-5.9%	COM	803607100
AXSM	AXSOME THERAPEUTICS INC	225,000	$8.618M	4.5%	$38.30 *	$31.36	+0.8%	COM	05464T104
COGT	COGENT BIOSCIENCES INC	900,000	$8.118M	4.2%	$9.02 *	$10.34	-34.0%	COM	19240Q201
—	HORIZON THERAPEUTICS PUB L	100,000	$7.976M	4.2%	$79.76	$79.76	—	SHS	G46188101
—	MIRATI THERAPEUTICS INC	110,000	$7.384M	3.8%	$67.13	$72.80	—	COM	60468T105
PCVX	VAXCYTE INC	325,000	$7.072M	3.7%	$21.76 *	$21.83	+6.0%	COM	92243G108
ASND	ASCENDIS PHARMA A/S	75,000	$6.972M	3.6%	$92.96	$131.68	—	SPONSORED ADR	04351P101
VRDN	VIRIDIAN THERAPEUTICS INC	600,000	$6.942M	3.6%	$11.57 *	$17.40	-22.8%	COM	92790C104
—	SEAGEN INC	35,000	$6.193M	3.2%	$176.94	$176.94	—	COM	81181C104
—	KARUNA THERAPEUTICS INC	45,000	$5.693M	3.0%	$126.51	$126.78	—	COM	48576A100
—	MERUS N V	250,000	$5.66M	2.9%	$22.64	$29.12	—	COM	N5749R100
—	IVERIC BIO INC	500,000	$4.81M	2.5%	$9.62	$7.65	—	COM	46583P102
—	CTI BIOPHARMA CORP	800,000	$4.776M	2.5%	$5.97	$2.98	—	COM	12648L601
RLMD	RELMADA THERAPEUTICS INC	250,000	$4.748M	2.5%	$18.99 *	$23.79	-8.3%	COM	75955J402
ARVN	ARVINAS INC	110,000	$4.63M	2.4%	$42.09 *	$28.07	+78.7%	COM	04335A105
SNDX	SYNDAX PHARMACEUTICALS INC	225,000	$4.329M	2.3%	$19.24 *	$18.21	-8.5%	COM	87164F105
DSGN	DESIGN THERAPEUTICS INC	275,000	$3.85M	2.0%	$14.00 *	$15.73	-14.1%	COM	25056L103
—	KEZAR LIFE SCIENCES INC	450,000	$3.722M	1.9%	$8.27	$15.75	—	COM	49372L100
XBI	SPDR SER TR	50,000	$3.714M	1.9%	$74.28	—	—	Call	78464A870
BCRX	BIOCRYST PHARMACEUTICALS INC	325,000	$3.439M	1.8%	$10.58 *	$16.04	-35.7%	COM	09058V103
—	RAPT THERAPEUTICS INC	165,000	$3.011M	1.6%	$18.25	$33.20	—	COM	75382E109
—	DICE THERAPEUTICS INC	150,000	$2.328M	1.2%	$15.52	$15.53	—	Call	23345J104
WHWK	AADI BIOSCIENCE INC	150,000	$1.848M	1.0%	$12.32 *	$25.11	-40.9%	COM	00032Q104
TARS	TARSUS PHARMACEUTICALS INC	120,000	$1.752M	0.9%	$14.60 *	$31.23	-51.9%	COM	87650L103
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	300,000	$1.575M	0.8%	$5.25 *	$6.29	0.0%	CLASS A ORD	61559X104
—	9 METERS BIOPHARMA INC	1,800,000	$469K	0.2%	$0.26	$1.25	—	COM	654405109
—	AEGLEA BIOTHERAPEUTICS INC	925,000	$467K	0.2%	$0.50	$1.84	—	COM	00773J103
—	DICE THERAPEUTICS INC	30,000	$466K	0.2%	$15.53	$15.53	—	COM	23345J104
ALNY	ALNYLAM PHARMACEUTICALS INC	1,900	$277K	0.1%	$145.79 *	$141.87	0.0%	COM	02043Q107