Ghost Tree Capital, LLC Hedge Fund

CIK: 0001595851 · Show all filings

Period: Q3 2022 (← Previous) (Next →)

Filing Date: Nov 14, 2022

Total Value: $356M (100.0% shares, 0.0% debt)

Holdings (44)

XBI SPDR SER TR 11.1%

Value $39.66M Shares 500,000 Est. Cost — Unrealized —

APLS APELLIS PHARMACEUTICALS INC 5.3%

Value $18.78M Shares 275,000 Est. Cost $51.44 Unrealized +15.0%

RLMD RELMADA THERAPEUTICS INC 5.2%

Value $18.51M Shares 500,000 Est. Cost $25.40 Unrealized +9.1%

— REATA PHARMACEUTICALS INC 5.1%

Value $18.22M Shares 725,000 Est. Cost $25.13 Unrealized —

RLMD RELMADA THERAPEUTICS INC 4.4%

Value $15.73M Shares 425,000 Est. Cost $25.40 Unrealized +9.1%

AMLX AMYLYX PHARMACEUTICALS INC 4.3%

Value $15.48M Shares 550,000 Est. Cost $24.95 Unrealized 0.0%

— DICE THERAPEUTICS INC 4.0%

Value $14.2M Shares 700,000 Est. Cost $15.53 Unrealized —

AMLX AMYLYX PHARMACEUTICALS INC 4.0%

Value $14.07M Shares 500,000 Est. Cost $24.95 Unrealized 0.0%

AXSM AXSOME THERAPEUTICS INC 3.8%

Value $13.39M Shares 300,000 Est. Cost $36.01 Unrealized +38.7%

— MIRATI THERAPEUTICS INC 3.4%

Value $12.22M Shares 175,000 Est. Cost $71.70 Unrealized —

SRPT SAREPTA THERAPEUTICS INC 3.4%

Value $12.16M Shares 110,000 Est. Cost $78.15 Unrealized +29.0%

— CTI BIOPHARMA CORP 3.3%

Value $11.64M Shares 2,000,000 Est. Cost $4.68 Unrealized —

VRDN VIRIDIAN THERAPEUTICS INC 3.1%

Value $10.97M Shares 535,000 Est. Cost $17.40 Unrealized +3.3%

— REVANCE THERAPEUTICS INC 3.0%

Value $10.53M Shares 390,000 Est. Cost $27.00 Unrealized —

ASND ASCENDIS PHARMA A/S 2.8%

Value $9.81M Shares 95,000 Est. Cost $125.70 Unrealized —

COGT COGENT BIOSCIENCES INC 2.5%

Value $8.952M Shares 600,000 Est. Cost $10.34 Unrealized +32.5%

PCVX VAXCYTE INC 2.4%

Value $8.64M Shares 360,000 Est. Cost $22.18 Unrealized +14.3%

— IVERIC BIO INC 2.3%

Value $8.319M Shares 463,700 Est. Cost $7.65 Unrealized —

— SEAGEN INC 1.9%

Value $6.842M Shares 50,000 Est. Cost $176.94 Unrealized —

— KARUNA THERAPEUTICS INC 1.9%

Value $6.748M Shares 30,000 Est. Cost $126.78 Unrealized —

AXSM AXSOME THERAPEUTICS INC 1.9%

Value $6.693M Shares 150,000 Est. Cost $36.01 Unrealized +38.7%

BCRX BIOCRYST PHARMACEUTICALS INC 1.9%

Value $6.615M Shares 525,000 Est. Cost $14.83 Unrealized -13.2%

ALT ALTIMMUNE INC 1.6%

Value $5.555M Shares 435,000 Est. Cost $14.76 Unrealized 0.0%

— TRICIDA INC 1.5%

Value $5.24M Shares 500,000 Est. Cost $10.48 Unrealized —

FOLD AMICUS THERAPEUTICS INC 1.5%

Value $5.22M Shares 500,000 Est. Cost $11.01 Unrealized +1.2%

— REATA PHARMACEUTICALS INC 1.4%

Value $5.026M Shares 200,000 Est. Cost $25.13 Unrealized —

SNDX SYNDAX PHARMACEUTICALS INC 1.3%

Value $4.806M Shares 200,000 Est. Cost $18.21 Unrealized +23.2%

— HORIZON THERAPEUTICS PUB L 1.3%

Value $4.642M Shares 75,000 Est. Cost $79.76 Unrealized —

— KEZAR LIFE SCIENCES INC 1.3%

Value $4.52M Shares 525,000 Est. Cost $14.73 Unrealized —

— ASTRIA THERAPEUTICS INC 1.3%

Value $4.52M Shares 500,000 Est. Cost $9.04 Unrealized —

— BLUEPRINT MEDICINES CORP 1.2%

Value $4.283M Shares 65,000 Est. Cost $65.89 Unrealized —

WHWK AADI BIOSCIENCE INC 0.8%

Value $2.826M Shares 200,000 Est. Cost $22.12 Unrealized -40.6%

— INTRA-CELLULAR THERAPIES INC 0.8%

Value $2.792M Shares 60,000 Est. Cost $46.53 Unrealized —

— AEROVATE THERAPEUTICS INC 0.7%

Value $2.487M Shares 150,000 Est. Cost $16.58 Unrealized —

MLTX MOONLAKE IMMUNOTHERAPEUTICS 0.7%

Value $2.328M Shares 300,000 Est. Cost $6.29 Unrealized +12.0%

— RAPT THERAPEUTICS INC 0.6%

Value $2.165M Shares 90,000 Est. Cost $33.20 Unrealized —

— TRICIDA INC 0.6%

Value $2.096M Shares 200,000 Est. Cost $10.48 Unrealized —

TARS TARSUS PHARMACEUTICALS INC 0.6%

Value $2.054M Shares 120,000 Est. Cost $31.23 Unrealized -49.2%

DSGN DESIGN THERAPEUTICS INC 0.5%

Value $1.672M Shares 100,000 Est. Cost $15.73 Unrealized +26.5%

MDGL MADRIGAL PHARMACEUTICALS INC 0.5%

Value $1.625M Shares 25,000 Est. Cost $69.48 Unrealized 0.0%

RYTM RHYTHM PHARMACEUTICALS INC 0.4%

Value $1.593M Shares 65,000 Est. Cost $18.60 Unrealized 0.0%

— IVERIC BIO INC 0.3%

Value $1.1M Shares 61,300 Est. Cost $7.65 Unrealized —

BIIB BIOGEN INC 0.3%

Value $1.001M Shares 3,750 Est. Cost $212.38 Unrealized 0.0%

— AEGLEA BIOTHERAPEUTICS INC 0.1%

Value $526K Shares 1,000,000 Est. Cost $1.74 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
XBI	SPDR SER TR	500,000	$39.66M	11.1%	—	—	Put	78464A870
APLS	APELLIS PHARMACEUTICALS INC	275,000	$18.78M	5.3%	$51.44	+15.0%	COM	03753U106
RLMD	RELMADA THERAPEUTICS INC	500,000	$18.51M	5.2%	$25.40	+9.1%	Put	75955J402
—	REATA PHARMACEUTICALS INC	725,000	$18.22M	5.1%	$25.13	—	CL A	75615P103
RLMD	RELMADA THERAPEUTICS INC	425,000	$15.73M	4.4%	$25.40	+9.1%	COM	75955J402
AMLX	AMYLYX PHARMACEUTICALS INC	550,000	$15.48M	4.3%	$24.95	0.0%	COM	03237H101
—	DICE THERAPEUTICS INC	700,000	$14.2M	4.0%	$15.53	—	Call	23345J104
AMLX	AMYLYX PHARMACEUTICALS INC	500,000	$14.07M	4.0%	$24.95	0.0%	Put	03237H101
AXSM	AXSOME THERAPEUTICS INC	300,000	$13.39M	3.8%	$36.01	+38.7%	COM	05464T104
—	MIRATI THERAPEUTICS INC	175,000	$12.22M	3.4%	$71.70	—	COM	60468T105
SRPT	SAREPTA THERAPEUTICS INC	110,000	$12.16M	3.4%	$78.15	+29.0%	COM	803607100
—	CTI BIOPHARMA CORP	2,000,000	$11.64M	3.3%	$4.68	—	COM	12648L601
VRDN	VIRIDIAN THERAPEUTICS INC	535,000	$10.97M	3.1%	$17.40	+3.3%	COM	92790C104
—	REVANCE THERAPEUTICS INC	390,000	$10.53M	3.0%	$27.00	—	COM	761330109
ASND	ASCENDIS PHARMA A/S	95,000	$9.81M	2.8%	$125.70	—	SPONSORED ADR	04351P101
COGT	COGENT BIOSCIENCES INC	600,000	$8.952M	2.5%	$10.34	+32.5%	COM	19240Q201
PCVX	VAXCYTE INC	360,000	$8.64M	2.4%	$22.18	+14.3%	COM	92243G108
—	IVERIC BIO INC	463,700	$8.319M	2.3%	$7.65	—	COM	46583P102
—	SEAGEN INC	50,000	$6.842M	1.9%	$176.94	—	Call	81181C104
—	KARUNA THERAPEUTICS INC	30,000	$6.748M	1.9%	$126.78	—	COM	48576A100
AXSM	AXSOME THERAPEUTICS INC	150,000	$6.693M	1.9%	$36.01	+38.7%	Call	05464T104
BCRX	BIOCRYST PHARMACEUTICALS INC	525,000	$6.615M	1.9%	$14.83	-13.2%	COM	09058V103
ALT	ALTIMMUNE INC	435,000	$5.555M	1.6%	$14.76	0.0%	COM NEW	02155H200
—	TRICIDA INC	500,000	$5.24M	1.5%	$10.48	—	Call	89610F101
FOLD	AMICUS THERAPEUTICS INC	500,000	$5.22M	1.5%	$11.01	+1.2%	COM	03152W109
—	REATA PHARMACEUTICALS INC	200,000	$5.026M	1.4%	$25.13	—	Call	75615P103
SNDX	SYNDAX PHARMACEUTICALS INC	200,000	$4.806M	1.3%	$18.21	+23.2%	COM	87164F105
—	HORIZON THERAPEUTICS PUB L	75,000	$4.642M	1.3%	$79.76	—	SHS	G46188101
—	KEZAR LIFE SCIENCES INC	525,000	$4.52M	1.3%	$14.73	—	COM	49372L100
—	ASTRIA THERAPEUTICS INC	500,000	$4.52M	1.3%	$9.04	—	COM	04635X102
—	BLUEPRINT MEDICINES CORP	65,000	$4.283M	1.2%	$65.89	—	COM	09627Y109
WHWK	AADI BIOSCIENCE INC	200,000	$2.826M	0.8%	$22.12	-40.6%	COM	00032Q104
—	INTRA-CELLULAR THERAPIES INC	60,000	$2.792M	0.8%	$46.53	—	COM	46116X101
—	AEROVATE THERAPEUTICS INC	150,000	$2.487M	0.7%	$16.58	—	COM	008064107
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	300,000	$2.328M	0.7%	$6.29	+12.0%	CLASS A ORD	61559X104
—	RAPT THERAPEUTICS INC	90,000	$2.165M	0.6%	$33.20	—	COM	75382E109
—	TRICIDA INC	200,000	$2.096M	0.6%	$10.48	—	COM	89610F101
TARS	TARSUS PHARMACEUTICALS INC	120,000	$2.054M	0.6%	$31.23	-49.2%	COM	87650L103
DSGN	DESIGN THERAPEUTICS INC	100,000	$1.672M	0.5%	$15.73	+26.5%	COM	25056L103
MDGL	MADRIGAL PHARMACEUTICALS INC	25,000	$1.625M	0.5%	$69.48	0.0%	COM	558868105
RYTM	RHYTHM PHARMACEUTICALS INC	65,000	$1.593M	0.4%	$18.60	0.0%	COM	76243J105
—	IVERIC BIO INC	61,300	$1.1M	0.3%	$7.65	—	Call	46583P102
BIIB	BIOGEN INC	3,750	$1.001M	0.3%	$212.38	0.0%	COM	09062X103
—	AEGLEA BIOTHERAPEUTICS INC	1,000,000	$526K	0.1%	$1.74	—	COM	00773J103