Ghost Tree Capital, LLC Hedge Fund

CIK: 0001595851 · Show all filings

Period: Q4 2022 (← Previous) (Next →)

Filing Date: Feb 14, 2023

Total Value: $234M (100.0% shares, 0.0% debt)

Holdings (35)

— REATA PHARMACEUTICALS INC 8.1%

Value $19M Shares 500,000 Share Price $37.99 Est. Cost/Share $25.13 Unrealized @ Report Date —

AXSM AXSOME THERAPEUTICS INC 7.7%

Value $18.13M Shares 235,000 Share Price $77.13 * Est. Cost/Share $36.01 Unrealized @ Report Date +66.0%

ASND ASCENDIS PHARMA A/S 6.8%

Value $15.88M Shares 130,000 Share Price $122.13 Est. Cost/Share $124.74 Unrealized @ Report Date —

APLS APELLIS PHARMACEUTICALS INC 6.6%

Value $15.51M Shares 300,000 Share Price $51.71 * Est. Cost/Share $51.57 Unrealized @ Report Date +2.8%

QQQ INVESCO QQQ TR 5.7%

Value $13.31M Shares 50,000 Share Price $266.28 Est. Cost/Share $266.28 Unrealized @ Report Date —

AMLX AMYLYX PHARMACEUTICALS INC 5.5%

Value $12.93M Shares 350,000 Share Price $36.95 * Est. Cost/Share $24.95 Unrealized @ Report Date +42.2%

— CTI BIOPHARMA CORP 4.7%

Value $11.12M Shares 1,850,000 Share Price $6.01 Est. Cost/Share $4.68 Unrealized @ Report Date —

— SEAGEN INC 4.7%

Value $10.92M Shares 85,000 Share Price $128.51 Est. Cost/Share $128.51 Unrealized @ Report Date —

— IVERIC BIO INC 4.1%

Value $9.635M Shares 450,000 Share Price $21.41 Est. Cost/Share $7.65 Unrealized @ Report Date —

COGT COGENT BIOSCIENCES INC 3.9%

Value $9.248M Shares 800,000 Share Price $11.56 * Est. Cost/Share $10.85 Unrealized @ Report Date +14.2%

— MIRATI THERAPEUTICS INC 3.9%

Value $9.062M Shares 200,000 Share Price $45.31 Est. Cost/Share $68.40 Unrealized @ Report Date —

IOVA IOVANCE BIOTHERAPEUTICS INC 3.5%

Value $8.307M Shares 1,300,000 Share Price $6.39 * Est. Cost/Share $7.81 Unrealized @ Report Date 0.0%

— KARUNA THERAPEUTICS INC 3.4%

Value $7.86M Shares 40,000 Share Price $196.50 Est. Cost/Share $144.21 Unrealized @ Report Date —

PCVX VAXCYTE INC 3.3%

Value $7.672M Shares 160,000 Share Price $47.95 * Est. Cost/Share $22.18 Unrealized @ Report Date +77.0%

SRPT SAREPTA THERAPEUTICS INC 3.0%

Value $7.127M Shares 55,000 Share Price $129.58 * Est. Cost/Share $78.15 Unrealized @ Report Date +48.3%

— ASTRIA THERAPEUTICS INC 2.9%

Value $6.701M Shares 450,000 Share Price $14.89 Est. Cost/Share $9.04 Unrealized @ Report Date —

MDGL MADRIGAL PHARMACEUTICALS INC 2.5%

Value $5.805M Shares 20,000 Share Price $290.25 * Est. Cost/Share $69.48 Unrealized @ Report Date +40.8%

— REVANCE THERAPEUTICS INC 2.4%

Value $5.538M Shares 300,000 Share Price $18.46 Est. Cost/Share $27.00 Unrealized @ Report Date —

VRDN VIRIDIAN THERAPEUTICS INC 2.1%

Value $4.82M Shares 165,000 Share Price $29.21 * Est. Cost/Share $17.40 Unrealized @ Report Date +32.4%

— AKERO THERAPEUTICS INC 2.0%

Value $4.658M Shares 85,000 Share Price $54.80 Est. Cost/Share $54.80 Unrealized @ Report Date —

— PROVENTION BIO INC 1.8%

Value $4.228M Shares 400,000 Share Price $10.57 Est. Cost/Share $10.57 Unrealized @ Report Date —

— AEROVATE THERAPEUTICS INC 1.7%

Value $3.956M Shares 135,000 Share Price $29.30 Est. Cost/Share $16.58 Unrealized @ Report Date —

SNDX SYNDAX PHARMACEUTICALS INC 1.6%

Value $3.818M Shares 150,000 Share Price $25.45 * Est. Cost/Share $18.21 Unrealized @ Report Date +28.1%

VKTX VIKING THERAPEUTICS INC 1.2%

Value $2.82M Shares 300,000 Share Price $9.40 * Est. Cost/Share $4.46 Unrealized @ Report Date 0.0%

BCRX BIOCRYST PHARMACEUTICALS INC 1.1%

Value $2.583M Shares 225,000 Share Price $11.48 * Est. Cost/Share $14.83 Unrealized @ Report Date -15.9%

— RAPT THERAPEUTICS INC 1.1%

Value $2.475M Shares 125,000 Share Price $19.80 Est. Cost/Share $29.45 Unrealized @ Report Date —

— KEZAR LIFE SCIENCES INC 1.0%

Value $2.393M Shares 339,907 Share Price $7.04 Est. Cost/Share $14.73 Unrealized @ Report Date —

RNAM AVIDITY BIOSCIENCES INC 0.9%

Value $2.219M Shares 100,000 Share Price $22.19 * Est. Cost/Share $14.91 Unrealized @ Report Date 0.0%

TARS TARSUS PHARMACEUTICALS INC 0.5%

Value $1.173M Shares 80,000 Share Price $14.66 * Est. Cost/Share $31.23 Unrealized @ Report Date -47.0%

WHWK AADI BIOSCIENCE INC 0.5%

Value $1.155M Shares 90,000 Share Price $12.83 Est. Cost/Share $22.12 Unrealized @ Report Date -41.0%

— PROMETHEUS BIOSCIENCES INC 0.5%

Value $1.089M Shares 9,896 Share Price $110.04 Est. Cost/Share $110.04 Unrealized @ Report Date —

— X4 PHARMACEUTICALS INC 0.4%

Value $993K Shares 1,000,000 Share Price $0.99 Est. Cost/Share $0.99 Unrealized @ Report Date —

— BLUEPRINT MEDICINES CORP 0.4%

Value $876K Shares 20,000 Share Price $43.80 Est. Cost/Share $65.89 Unrealized @ Report Date —

DSGN DESIGN THERAPEUTICS INC 0.4%

Value $850K Shares 82,853 Share Price $10.26 * Est. Cost/Share $15.73 Unrealized @ Report Date -13.9%

— AEGLEA BIOTHERAPEUTICS INC 0.2%

Value $360K Shares 800,000 Share Price $0.45 Est. Cost/Share $1.74 Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
—	REATA PHARMACEUTICALS INC	500,000	$19M	8.1%	$37.99	$25.13	—	CL A	75615P103
AXSM	AXSOME THERAPEUTICS INC	235,000	$18.13M	7.7%	$77.13 *	$36.01	+66.0%	COM	05464T104
ASND	ASCENDIS PHARMA A/S	130,000	$15.88M	6.8%	$122.13	$124.74	—	SPONSORED ADR	04351P101
APLS	APELLIS PHARMACEUTICALS INC	300,000	$15.51M	6.6%	$51.71 *	$51.57	+2.8%	COM	03753U106
QQQ	INVESCO QQQ TR	50,000	$13.31M	5.7%	$266.28	$266.28	—	UNIT SER 1	46090E103
AMLX	AMYLYX PHARMACEUTICALS INC	350,000	$12.93M	5.5%	$36.95 *	$24.95	+42.2%	COM	03237H101
—	CTI BIOPHARMA CORP	1,850,000	$11.12M	4.7%	$6.01	$4.68	—	COM	12648L601
—	SEAGEN INC	85,000	$10.92M	4.7%	$128.51	$128.51	—	COM	81181C104
—	IVERIC BIO INC	450,000	$9.635M	4.1%	$21.41	$7.65	—	COM	46583P102
COGT	COGENT BIOSCIENCES INC	800,000	$9.248M	3.9%	$11.56 *	$10.85	+14.2%	COM	19240Q201
—	MIRATI THERAPEUTICS INC	200,000	$9.062M	3.9%	$45.31	$68.40	—	COM	60468T105
IOVA	IOVANCE BIOTHERAPEUTICS INC	1,300,000	$8.307M	3.5%	$6.39 *	$7.81	0.0%	COM	462260100
—	KARUNA THERAPEUTICS INC	40,000	$7.86M	3.4%	$196.50	$144.21	—	COM	48576A100
PCVX	VAXCYTE INC	160,000	$7.672M	3.3%	$47.95 *	$22.18	+77.0%	COM	92243G108
SRPT	SAREPTA THERAPEUTICS INC	55,000	$7.127M	3.0%	$129.58 *	$78.15	+48.3%	COM	803607100
—	ASTRIA THERAPEUTICS INC	450,000	$6.701M	2.9%	$14.89	$9.04	—	COM	04635X102
MDGL	MADRIGAL PHARMACEUTICALS INC	20,000	$5.805M	2.5%	$290.25 *	$69.48	+40.8%	COM	558868105
—	REVANCE THERAPEUTICS INC	300,000	$5.538M	2.4%	$18.46	$27.00	—	COM	761330109
VRDN	VIRIDIAN THERAPEUTICS INC	165,000	$4.82M	2.1%	$29.21 *	$17.40	+32.4%	COM	92790C104
—	AKERO THERAPEUTICS INC	85,000	$4.658M	2.0%	$54.80	$54.80	—	COM	00973Y108
—	PROVENTION BIO INC	400,000	$4.228M	1.8%	$10.57	$10.57	—	COM	74374N102
—	AEROVATE THERAPEUTICS INC	135,000	$3.956M	1.7%	$29.30	$16.58	—	COM	008064107
SNDX	SYNDAX PHARMACEUTICALS INC	150,000	$3.818M	1.6%	$25.45 *	$18.21	+28.1%	COM	87164F105
VKTX	VIKING THERAPEUTICS INC	300,000	$2.82M	1.2%	$9.40 *	$4.46	0.0%	COM	92686J106
BCRX	BIOCRYST PHARMACEUTICALS INC	225,000	$2.583M	1.1%	$11.48 *	$14.83	-15.9%	COM	09058V103
—	RAPT THERAPEUTICS INC	125,000	$2.475M	1.1%	$19.80	$29.45	—	COM	75382E109
—	KEZAR LIFE SCIENCES INC	339,907	$2.393M	1.0%	$7.04	$14.73	—	COM	49372L100
RNAM	AVIDITY BIOSCIENCES INC	100,000	$2.219M	0.9%	$22.19 *	$14.91	0.0%	COM	05370A108
TARS	TARSUS PHARMACEUTICALS INC	80,000	$1.173M	0.5%	$14.66 *	$31.23	-47.0%	COM	87650L103
WHWK	AADI BIOSCIENCE INC	90,000	$1.155M	0.5%	$12.83	$22.12	-41.0%	COM	00032Q104
—	PROMETHEUS BIOSCIENCES INC	9,896	$1.089M	0.5%	$110.04	$110.04	—	COM	74349U108
—	X4 PHARMACEUTICALS INC	1,000,000	$993K	0.4%	$0.99	$0.99	—	COM	98420X103
—	BLUEPRINT MEDICINES CORP	20,000	$876K	0.4%	$43.80	$65.89	—	COM	09627Y109
DSGN	DESIGN THERAPEUTICS INC	82,853	$850K	0.4%	$10.26 *	$15.73	-13.9%	COM	25056L103
—	AEGLEA BIOTHERAPEUTICS INC	800,000	$360K	0.2%	$0.45	$1.74	—	COM	00773J103