SILVERARC CAPITAL MANAGEMENT, LLC Quant / Systematic

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	SPDR SERIES TRUST	825,000	$105,377	10.8%	—	—	PUT	78464A950
ZBIO	ZENAS BIOPHARMA INC	1,135,935	$22,208	2.3%	$21.89	0.0%	COM	98937L105
SRRK	SCHOLAR ROCK HLDG CORP	339,613	$16,695	1.7%	$45.48	0.0%	COM	80706P103
ALKS	ALKERMES PLC	460,314	$16,277	1.7%	$32.34	0.0%	SHS	G01767105
IRON	DISC MEDICINE INC	196,028	$12,534	1.3%	$74.04	0.0%	COM	254604101
HLXC	HELIX ACQUISITION CORP III	1,208,986	$12,283	1.3%	$10.16	—	USD CL A ORD SHS	G4444S107
XENE	XENON PHARMACEUTICALS INC	197,759	$11,500	1.2%	$41.98	0.0%	COM	98420N105
IMVT	IMMUNOVANT INC	414,236	$10,290	1.1%	$26.26	0.0%	COM	45258J102
SVRA	SAVARA INC	1,430,982	$7,813	0.8%	$5.69	0.0%	COM	805111101
—	SYNDAX PHARMACEUTICALS INC	320,000	$7,475	0.8%	—	—	CALL	87164F905
ORKA	ORUKA THERAPEUTICS INC	150,908	$7,402	0.8%	$32.45	0.0%	COM	687604108
—	CELCUITY INC	54,500	$6,221	0.6%	—	—	CALL	15102K900
CYTK	CYTOKINETICS INC	71,203	$4,693	0.5%	$64.44	0.0%	COM NEW	23282W605
CLYM	CLIMB BIO INC	684,908	$4,692	0.5%	$5.00	0.0%	COM	28658R106
ZURA	ZURA BIO LTD	560,651	$3,336	0.3%	$5.88	0.0%	CLASS A ORD SHS	G9TY5A101
CAMP	CAMP4 THERAPEUTICS CORP	653,594	$2,882	0.3%	$4.67	0.0%	COM	13463J101
ANNX	ANNEXON INC	496,461	$2,750	0.3%	$5.75	0.0%	COM	03589W102
CBIO	CRESCENT BIOPHARMA INC.	130,500	$2,397	0.2%	$11.06	0.0%	COM	G2545C104
MNPR	MONOPAR THERAPEUTICS INC	43,488	$2,383	0.2%	$62.79	0.0%	COM NEW	61023L207
OVID	OVID THERAPEUTICS INC	1,000,000	$2,220	0.2%	$1.60	0.0%	COM	690469101
CMPS	COMPASS PATHWAYS PLC	300,000	$1,659	0.2%	$5.53	—	SPONSORED ADS	20451W101
NMRA	NEUMORA THERAPEUTICS INC.	818,156	$1,595	0.2%	$2.46	0.0%	COM	640979100
REPL	REPLIMUNE GROUP INC	171,936	$1,315	0.1%	$7.81	0.0%	COM	76029N106
GENB	GENERATE BIOMEDICINES INC	100,000	$1,250	0.1%	$12.50	—	COM SHS	370920100
—	COMPASS THERAPEUTICS INC	172,400	$912	0.1%	—	—	CALL	20454B904

Increased Positions (16)

ERAS ERASCA INC 3.1%

Value ($000) $29,962 (+511.3%) Shares 1,851,812 (+40.5%) Est. Cost $4.46 Unrealized +124.9%

KALV KALVISTA PHARMACEUTICALS INC 5.9%

Value ($000) $57,902 (+47.7%) Shares 2,876,407 (+18.5%) Est. Cost $12.52 Unrealized +23.7%

ASND ASCENDIS PHARMA A/S 2.9%

Value ($000) $28,513 (+171.6%) Shares 124,658 (+153.2%) Est. Cost $196.77 Unrealized —

GLUE MONTE ROSA THERAPEUTICS INC 3.4%

Value ($000) $32,934 (+104.1%) Shares 2,002,040 (+94.5%) Est. Cost $14.13 Unrealized +46.2%

IMNM IMMUNOME INC 4.1%

Value ($000) $40,466 (+67.3%) Shares 1,850,278 (+64.3%) Est. Cost $19.71 Unrealized +17.0%

RYTM RHYTHM PHARMACEUTICALS INC 2.7%

Value ($000) $26,613 (+82.9%) Shares 306,000 (+125.1%) Est. Cost $74.67 Unrealized +37.7%

SNDX SYNDAX PHARMACEUTICALS INC 2.1%

Value ($000) $20,767 (+53.7%) Shares 888,987 (+38.3%) Est. Cost $18.33 Unrealized +13.2%

CNTA CENTESSA PHARMACEUTICALS PLC 1.9%

Value ($000) $18,523 (+61.6%) Shares 466,345 (+1.8%) Est. Cost $24.95 Unrealized —

COGT COGENT BIOSCIENCES INC 5.2%

Value ($000) $50,583 (+14.4%) Shares 1,314,189 (+5.5%) Est. Cost $18.51 Unrealized +101.9%

NUVL NUVALENT INC 3.7%

Value ($000) $36,361 (+16.1%) Shares 354,914 (+14.0%) Est. Cost $77.35 Unrealized +34.0%

FULC FULCRUM THERAPEUTICS INC 0.3%

Value ($000) $3,221 (-27.8%) Shares 419,949 (+6.4%) Est. Cost $10.19 Unrealized +1.8%

ABEO ABEONA THERAPEUTICS INC 0.3%

Value ($000) $2,907 (-12.1%) Shares 648,942 (+3.4%) Est. Cost $5.72 Unrealized -9.7%

EWTX EDGEWISE THERAPEUTICS INC 0.1%

Value ($000) $1,342 (+28.6%) Shares 42,615 (+1.3%) Est. Cost $20.18 Unrealized +39.6%

GH GUARDANT HEALTH INC 0.9%

Value ($000) $9,100 (-3.1%) Shares 98,514 (+7.2%) Est. Cost $90.66 Unrealized +18.5%

IBIO IBIO INC 0.0%

Value ($000) $429 (+109.9%) Shares 226,000 (+113.2%) Est. Cost $1.87 Unrealized +23.8%

CERS CERUS CORP 0.6%

Value ($000) $5,781 (-0.3%) Shares 3,176,547 (+12.9%) Est. Cost $3.16 Unrealized -25.8%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
ERAS	ERASCA INC	1,851,812 (+40.5%)	$29,962 (+511.3%)	3.1%	$4.46	+124.9%	COM	29479A108
KALV	KALVISTA PHARMACEUTICALS INC	2,876,407 (+18.5%)	$57,902 (+47.7%)	5.9%	$12.52	+23.7%	COM	483497103
ASND	ASCENDIS PHARMA A/S	124,658 (+153.2%)	$28,513 (+171.6%)	2.9%	$196.77	—	SPONSORED ADR	04351P101
GLUE	MONTE ROSA THERAPEUTICS INC	2,002,040 (+94.5%)	$32,934 (+104.1%)	3.4%	$14.13	+46.2%	COM	61225M102
IMNM	IMMUNOME INC	1,850,278 (+64.3%)	$40,466 (+67.3%)	4.1%	$19.71	+17.0%	COM	45257U108
RYTM	RHYTHM PHARMACEUTICALS INC	306,000 (+125.1%)	$26,613 (+82.9%)	2.7%	$74.67	+37.7%	COM	76243J105
SNDX	SYNDAX PHARMACEUTICALS INC	888,987 (+38.3%)	$20,767 (+53.7%)	2.1%	$18.33	+13.2%	COM	87164F105
CNTA	CENTESSA PHARMACEUTICALS PLC	466,345 (+1.8%)	$18,523 (+61.6%)	1.9%	$24.95	—	SPONSORED ADS	152309100
COGT	COGENT BIOSCIENCES INC	1,314,189 (+5.5%)	$50,583 (+14.4%)	5.2%	$18.51	+101.9%	COM	19240Q201
NUVL	NUVALENT INC	354,914 (+14.0%)	$36,361 (+16.1%)	3.7%	$77.35	+34.0%	COM	670703107
FULC	FULCRUM THERAPEUTICS INC	419,949 (+6.4%)	$3,221 (-27.8%)	0.3%	$10.19	+1.8%	COM	359616109
ABEO	ABEONA THERAPEUTICS INC	648,942 (+3.4%)	$2,907 (-12.1%)	0.3%	$5.72	-9.7%	COM NEW	00289Y206
EWTX	EDGEWISE THERAPEUTICS INC	42,615 (+1.3%)	$1,342 (+28.6%)	0.1%	$20.18	+39.6%	COM	28036F105
GH	GUARDANT HEALTH INC	98,514 (+7.2%)	$9,100 (-3.1%)	0.9%	$90.66	+18.5%	COM	40131M109
IBIO	IBIO INC	226,000 (+113.2%)	$429 (+109.9%)	0.0%	$1.87	+23.8%	COM NEW	451033708
CERS	CERUS CORP	3,176,547 (+12.9%)	$5,781 (-0.3%)	0.6%	$3.16	-25.8%	COM	157085101

Exited Positions (20)

VRDN VIRIDIAN THERAPEUTICS INC 1.1%

Value ($000) $10,847 Shares 348,569 Est. Cost $20.44 Unrealized +50.9%

PFE PFIZER INC 1.1%

Value ($000) $10,436 Shares 419,134 Est. Cost $25.03 Unrealized +4.6%

AVTX AVALO THERAPEUTICS INC 1.0%

Value ($000) $9,524 Shares 524,436 Est. Cost $8.60 Unrealized +80.2%

GOSS GOSSAMER BIO INC 0.7%

Value ($000) $6,621 Shares 2,135,722 Est. Cost $1.12 Unrealized +100.9%

LXEO LEXEO THERAPEUTICS INC 0.6%

Value ($000) $6,133 Shares 617,608 Est. Cost $4.84 Unrealized +55.8%

AMLX AMYLYX PHARMACEUTICALS INC 0.6%

Value ($000) $6,115 Shares 506,242 Est. Cost $9.41 Unrealized +48.6%

SLNO SOLENO THERAPEUTICS INC 0.6%

Value ($000) $5,440 Shares 117,485 Est. Cost $54.83 Unrealized -24.1%

OLMA OLEMA PHARMACEUTICALS INC 0.5%

Value ($000) $5,157 Shares 206,280 Est. Cost $6.00 Unrealized +323.9%

— KALVISTA PHARMACEUTICALS INC 0.5%

Value ($000) $4,693 Shares 290,600 Est. Cost — Unrealized —

MLYS MINERALYS THERAPEUTICS INC 0.4%

Value ($000) $3,447 Shares 94,983 Est. Cost $16.01 Unrealized +95.8%

RLAY RELAY THERAPEUTICS INC 0.3%

Value ($000) $3,368 Shares 398,167 Est. Cost $7.14 Unrealized +16.3%

QURE UNIQURE NV 0.3%

Value ($000) $3,016 Shares 126,047 Est. Cost $15.14 Unrealized +55.6%

TARS TARSUS PHARMACEUTICALS INC 0.3%

Value ($000) $2,958 Shares 36,124 Est. Cost $74.67 Unrealized -6.6%

KYMR KYMERA THERAPEUTICS INC 0.3%

Value ($000) $2,691 Shares 34,589 Est. Cost $67.53 Unrealized +14.9%

— ULTRAGENYX PHARMACEUTICAL IN 0.3%

Value ($000) $2,530 Shares 110,000 Est. Cost — Unrealized —

CTMX CYTOMX THERAPEUTICS INC 0.2%

Value ($000) $1,644 Shares 385,974 Est. Cost $3.80 Unrealized +37.6%

XFOR X4 PHARMACEUTICALS INC 0.1%

Value ($000) $1,430 Shares 357,387 Est. Cost $3.63 Unrealized +0.1%

FDMT 4D MOLECULAR THERAPEUTICS IN 0.1%

Value ($000) $750 Shares 100,000 Est. Cost $10.14 Unrealized -15.5%

RAPP RAPPORT THERAPEUTICS INC 0.0%

Value ($000) $293 Shares 9,659 Est. Cost $17.84 Unrealized +56.0%

PALI PALISADE BIO INC 0.0%

Value ($000) $240 Shares 102,108 Est. Cost $1.92 Unrealized -7.2%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
VRDN	VIRIDIAN THERAPEUTICS INC	348,569	$10,847	1.1%	$20.44	+50.9%	—	92790C104
PFE	PFIZER INC	419,134	$10,436	1.1%	$25.03	+4.6%	—	717081103
AVTX	AVALO THERAPEUTICS INC	524,436	$9,524	1.0%	$8.60	+80.2%	—	05338F306
GOSS	GOSSAMER BIO INC	2,135,722	$6,621	0.7%	$1.12	+100.9%	—	38341P102
LXEO	LEXEO THERAPEUTICS INC	617,608	$6,133	0.6%	$4.84	+55.8%	—	52886X107
AMLX	AMYLYX PHARMACEUTICALS INC	506,242	$6,115	0.6%	$9.41	+48.6%	—	03237H101
SLNO	SOLENO THERAPEUTICS INC	117,485	$5,440	0.6%	$54.83	-24.1%	—	834203309
OLMA	OLEMA PHARMACEUTICALS INC	206,280	$5,157	0.5%	$6.00	+323.9%	—	68062P106
—	KALVISTA PHARMACEUTICALS INC	290,600	$4,693	0.5%	—	—	CALL	483497903
MLYS	MINERALYS THERAPEUTICS INC	94,983	$3,447	0.4%	$16.01	+95.8%	—	603170101
RLAY	RELAY THERAPEUTICS INC	398,167	$3,368	0.3%	$7.14	+16.3%	—	75943R102
QURE	UNIQURE NV	126,047	$3,016	0.3%	$15.14	+55.6%	—	N90064101
TARS	TARSUS PHARMACEUTICALS INC	36,124	$2,958	0.3%	$74.67	-6.6%	—	87650L103
KYMR	KYMERA THERAPEUTICS INC	34,589	$2,691	0.3%	$67.53	+14.9%	—	501575104
—	ULTRAGENYX PHARMACEUTICAL IN	110,000	$2,530	0.3%	—	—	CALL	90400D908
CTMX	CYTOMX THERAPEUTICS INC	385,974	$1,644	0.2%	$3.80	+37.6%	—	23284F105
XFOR	X4 PHARMACEUTICALS INC	357,387	$1,430	0.1%	$3.63	+0.1%	—	98420X202
FDMT	4D MOLECULAR THERAPEUTICS IN	100,000	$750	0.1%	$10.14	-15.5%	—	35104E100
RAPP	RAPPORT THERAPEUTICS INC	9,659	$293	0.0%	$17.84	+56.0%	—	75383L102
PALI	PALISADE BIO INC	102,108	$240	0.0%	$1.92	-7.2%	—	696389402

Decreased Positions (27)

DNTH DIANTHUS THERAPEUTICS INC 5.6%

Value ($000) $54,946 (+77.7%) Shares 654,746 (-12.7%) Est. Cost $26.43 Unrealized +80.0%

ABVX ABIVAX SA 3.4%

Value ($000) $33,687 (-40.8%) Shares 302,530 (-28.3%) Est. Cost $84.90 Unrealized —

GUTS FRACTYL HEALTH INC 0.1%

Value ($000) $779 (-96.4%) Shares 1,701,625 (-82.7%) Est. Cost $1.40 Unrealized -14.2%

URGN UROGEN PHARMA LTD 2.8%

Value ($000) $27,025 (-33.6%) Shares 1,503,045 (-13.6%) Est. Cost $13.27 Unrealized +57.0%

VCYT VERACYTE INC 0.6%

Value ($000) $5,788 (-61.5%) Shares 179,700 (-49.7%) Est. Cost $34.23 Unrealized +14.9%

KOD KODIAK SCIENCES INC 3.9%

Value ($000) $37,812 (+32.2%) Shares 991,930 (-3.0%) Est. Cost $7.38 Unrealized +244.7%

— UNIQURE NV 0.8%

Value ($000) $8,175 (-52.6%) Shares 500,000 (-30.6%) Est. Cost — Unrealized —

INSM INSMED INC 0.6%

Value ($000) $5,862 (-52.7%) Shares 35,850 (-49.7%) Est. Cost $56.86 Unrealized +179.7%

ORIC ORIC PHARMACEUTICALS INC 1.4%

Value ($000) $13,937 (+52.6%) Shares 1,100,010 (-1.5%) Est. Cost $6.76 Unrealized +59.4%

BIIB BIOGEN INC 1.0%

Value ($000) $9,344 (-29.6%) Shares 50,967 (-32.4%) Est. Cost $135.17 Unrealized +35.6%

AARD AARDVARK THERAPEUTICS INC 0.0%

Value ($000) $127 (-96.8%) Shares 33,684 (-88.9%) Est. Cost $10.73 Unrealized +26.5%

CGON CG ONCOLOGY INC 1.1%

Value ($000) $11,259 (-24.9%) Shares 166,349 (-53.9%) Est. Cost $24.86 Unrealized +110.9%

CELC CELCUITY INC 4.2%

Value ($000) $40,851 (+9.2%) Shares 357,903 (-4.6%) Est. Cost $72.23 Unrealized +48.8%

BNTC BENITEC BIOPHARMA INC 0.8%

Value ($000) $7,644 (-22.4%) Shares 717,725 (-1.9%) Est. Cost $13.20 Unrealized -10.8%

CGEN COMPUGEN LTD 0.7%

Value ($000) $7,063 (+32.7%) Shares 3,315,845 (-4.7%) Est. Cost $1.61 Unrealized +14.1%

TELA TELA BIO INC 0.1%

Value ($000) $1,401 (-55.2%) Shares 2,259,312 (-14.7%) Est. Cost $4.46 Unrealized -79.3%

PCVX VAXCYTE INC 0.9%

Value ($000) $8,425 (+22.7%) Shares 144,981 (-2.6%) Est. Cost $32.81 Unrealized +60.8%

PRAX PRAXIS PRECISION MEDICINES I 2.4%

Value ($000) $23,053 (-5.2%) Shares 71,552 (-13.2%) Est. Cost $100.25 Unrealized +211.0%

CCCC C4 THERAPEUTICS INC 0.5%

Value ($000) $5,028 (+32.0%) Shares 1,911,785 (-4.1%) Est. Cost $2.40 Unrealized -13.0%

CMPX COMPASS THERAPEUTICS INC 0.5%

Value ($000) $4,544 (-19.5%) Shares 859,049 (-18.3%) Est. Cost $2.86 Unrealized +109.9%

ELUT ELUTIA INC 0.3%

Value ($000) $2,623 (+37.6%) Shares 2,498,020 (-9.2%) Est. Cost $3.14 Unrealized -70.3%

TRVI TREVI THERAPEUTICS INC 0.6%

Value ($000) $6,098 (-10.0%) Shares 511,127 (-5.6%) Est. Cost $3.55 Unrealized +208.1%

SRZN SURROZEN INC 0.4%

Value ($000) $4,202 (+18.2%) Shares 144,255 (-8.3%) Est. Cost $16.18 Unrealized +37.4%

CLDX CELLDEX THERAPEUTICS INC NEW 0.6%

Value ($000) $5,658 (+9.0%) Shares 178,378 (-6.6%) Est. Cost $27.17 Unrealized -6.5%

CTNM CONTINEUM THERAPEUTICS INC 0.4%

Value ($000) $3,941 (+12.1%) Shares 301,729 (-1.9%) Est. Cost $9.60 Unrealized +39.1%

ADGM ADAGIO MED HLDGS INC 0.0%

Value ($000) $290 (-45.9%) Shares 251,972 (-51.1%) Est. Cost $1.19 Unrealized -17.3%

SION SIONNA THERAPEUTICS INC 0.2%

Value ($000) $1,580 (-7.4%) Shares 39,417 (-4.9%) Est. Cost $15.09 Unrealized +160.1%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
DNTH	DIANTHUS THERAPEUTICS INC	654,746 (-12.7%)	$54,946 (+77.7%)	5.6%	$26.43	+80.0%	COM	252828108
ABVX	ABIVAX SA	302,530 (-28.3%)	$33,687 (-40.8%)	3.4%	$84.90	—	SPONSORED ADS	00370M103
GUTS	FRACTYL HEALTH INC	1,701,625 (-82.7%)	$779 (-96.4%)	0.1%	$1.40	-14.2%	COM	35168W103
URGN	UROGEN PHARMA LTD	1,503,045 (-13.6%)	$27,025 (-33.6%)	2.8%	$13.27	+57.0%	COM	M96088105
VCYT	VERACYTE INC	179,700 (-49.7%)	$5,788 (-61.5%)	0.6%	$34.23	+14.9%	COM	92337F107
KOD	KODIAK SCIENCES INC	991,930 (-3.0%)	$37,812 (+32.2%)	3.9%	$7.38	+244.7%	COM	50015M109
—	UNIQURE NV	500,000 (-30.6%)	$8,175 (-52.6%)	0.8%	—	—	CALL	N90064901
INSM	INSMED INC	35,850 (-49.7%)	$5,862 (-52.7%)	0.6%	$56.86	+179.7%	COM PAR $.01	457669307
ORIC	ORIC PHARMACEUTICALS INC	1,100,010 (-1.5%)	$13,937 (+52.6%)	1.4%	$6.76	+59.4%	COM	68622P109
BIIB	BIOGEN INC	50,967 (-32.4%)	$9,344 (-29.6%)	1.0%	$135.17	+35.6%	COM	09062X103
AARD	AARDVARK THERAPEUTICS INC	33,684 (-88.9%)	$127 (-96.8%)	0.0%	$10.73	+26.5%	COM	002942100
CGON	CG ONCOLOGY INC	166,349 (-53.9%)	$11,259 (-24.9%)	1.1%	$24.86	+110.9%	COM	156944100
CELC	CELCUITY INC	357,903 (-4.6%)	$40,851 (+9.2%)	4.2%	$72.23	+48.8%	COM	15102K100
BNTC	BENITEC BIOPHARMA INC	717,725 (-1.9%)	$7,644 (-22.4%)	0.8%	$13.20	-10.8%	COM NEW	08205P209
CGEN	COMPUGEN LTD	3,315,845 (-4.7%)	$7,063 (+32.7%)	0.7%	$1.61	+14.1%	ORD	M25722105
TELA	TELA BIO INC	2,259,312 (-14.7%)	$1,401 (-55.2%)	0.1%	$4.46	-79.3%	COM	872381108
PCVX	VAXCYTE INC	144,981 (-2.6%)	$8,425 (+22.7%)	0.9%	$32.81	+60.8%	COM	92243G108
PRAX	PRAXIS PRECISION MEDICINES I	71,552 (-13.2%)	$23,053 (-5.2%)	2.4%	$100.25	+211.0%	COM NEW	74006W207
CCCC	C4 THERAPEUTICS INC	1,911,785 (-4.1%)	$5,028 (+32.0%)	0.5%	$2.40	-13.0%	COM STK	12529R107
CMPX	COMPASS THERAPEUTICS INC	859,049 (-18.3%)	$4,544 (-19.5%)	0.5%	$2.86	+109.9%	COM	20454B104
ELUT	ELUTIA INC	2,498,020 (-9.2%)	$2,623 (+37.6%)	0.3%	$3.14	-70.3%	CL A COM	05479K106
TRVI	TREVI THERAPEUTICS INC	511,127 (-5.6%)	$6,098 (-10.0%)	0.6%	$3.55	+208.1%	COM	89532M101
SRZN	SURROZEN INC	144,255 (-8.3%)	$4,202 (+18.2%)	0.4%	$16.18	+37.4%	COM NEW	86889P208
CLDX	CELLDEX THERAPEUTICS INC NEW	178,378 (-6.6%)	$5,658 (+9.0%)	0.6%	$27.17	-6.5%	COM NEW	15117B202
CTNM	CONTINEUM THERAPEUTICS INC	301,729 (-1.9%)	$3,941 (+12.1%)	0.4%	$9.60	+39.1%	CL A	21217B100
ADGM	ADAGIO MED HLDGS INC	251,972 (-51.1%)	$290 (-45.9%)	0.0%	$1.19	-17.3%	COM	00534B100
SION	SIONNA THERAPEUTICS INC	39,417 (-4.9%)	$1,580 (-7.4%)	0.2%	$15.09	+160.1%	COM	829401108

Unchanged Positions (5)

SYRE SPYRE THERAPEUTICS INC 1.0%

Value ($000) $9,413 Shares 186,618 Est. Cost $26.13 Unrealized +32.2%

— FULCRUM THERAPEUTICS INC 0.3%

Value ($000) $3,006 Shares 391,900 Est. Cost — Unrealized —

NXTC NEXTCURE INC 0.2%

Value ($000) $1,880 Shares 176,057 Est. Cost $10.36 Unrealized +21.4%

RADX RADIOPHARM THERANOSTICS LTD 0.1%

Value ($000) $806 Shares 187,406 Est. Cost $4.49 Unrealized —

RCKTW ROCKET PHARMACEUTICALS INC 0.0%

Value ($000) $2 Shares 104,828 Est. Cost $0.11 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
SYRE	SPYRE THERAPEUTICS INC	186,618	$9,413	1.0%	$26.13	+32.2%	COM NEW	00773J202
—	FULCRUM THERAPEUTICS INC	391,900	$3,006	0.3%	—	—	CALL	359616909
NXTC	NEXTCURE INC	176,057	$1,880	0.2%	$10.36	+21.4%	COM NEW	65343E207
RADX	RADIOPHARM THERANOSTICS LTD	187,406	$806	0.1%	$4.49	—	SPONSORED ADS	75041J101
RCKTW	ROCKET PHARMACEUTICALS INC	104,828	$2	0.0%	$0.11	—	*W EXP 09/02/202	77313F114