Stonepine Capital Management, LLC Quant / Systematic

Location: Bend, OR

CIK: 0001440771 · Show all filings

Period: Q2 2026 (← Previous)

Filing Date: Aug 17, 2026

Total Value: $177M (100.0% shares, 0.0% debt)

Holdings (87)

New Positions (25)

INSM INSMED INC 3.2%
Value $5.6M Shares 40,000 Share Price $140.00 Est. Cost/Share — Unrealized @ Report Date —
ELOX ELOXX PHARMACEUTICALS INC 3.1%
Value $5.513M Shares 397,160 Share Price $13.88 Est. Cost/Share $13.88 Unrealized @ Report Date —
RARE ULTRAGENYX PHARMACEUTICAL IN 3.1%
Value $5.5M Shares 200,000 Share Price $27.50 Est. Cost/Share $33.39 Unrealized @ Report Date —
MDT MEDTRONIC PLC 2.5%
Value $4.375M Shares 50,000 Share Price $87.50 Est. Cost/Share — Unrealized @ Report Date —
INDV INDIVIOR PHARMACEUTICALS INC 2.3%
Value $4.103M Shares 100,000 Share Price $41.03 Est. Cost/Share $41.03 Unrealized @ Report Date —
ABT ABBOTT LABORATORIES 2.1%
Value $3.8M Shares 40,000 Share Price $95.00 Est. Cost/Share — Unrealized @ Report Date —
BSX BOSTON SCIENTIFIC CORP 1.8%
Value $3.25M Shares 50,000 Share Price $65.00 Est. Cost/Share — Unrealized @ Report Date —
BMRN BIOMARIN PHARMACEUTICAL INC 1.8%
Value $3.125M Shares 50,000 Share Price $62.50 Est. Cost/Share — Unrealized @ Report Date —
SPRB SPRUCE BIOSCIENCES INC 0.9%
Value $1.555M Shares 28,795 Share Price $54.00 Est. Cost/Share $54.00 Unrealized @ Report Date —
MLTX MOONLAKE IMMUNOTHERAPEUTICS 0.5%
Value $974K Shares 50,000 Share Price $19.47 Est. Cost/Share $19.47 Unrealized @ Report Date —
AZTR AZITRA INC 0.5%
Value $887K Shares 5,285,476 Share Price $0.17 Est. Cost/Share $0.17 Unrealized @ Report Date —
RARE ULTRAGENYX PHARMACEUTICAL IN 0.5%
Value $835K Shares 25,000 Share Price $33.39 Est. Cost/Share $33.39 Unrealized @ Report Date —
NVCT NUVECTIS PHARMA INC 0.4%
Value $736K Shares 40,000 Share Price $18.39 Est. Cost/Share $18.39 Unrealized @ Report Date —
ORKA ORUKA THERAPEUTICS INC 0.4%
Value $714K Shares 7,500 Share Price $95.17 Est. Cost/Share $95.17 Unrealized @ Report Date —
NGEN NERVGEN PHARMA CORP 0.3%
Value $560K Shares 271,678 Share Price $2.06 Est. Cost/Share $2.06 Unrealized @ Report Date —
CALC CALCIMEDICA INC 0.3%
Value $545K Shares 622,432 Share Price $0.88 Est. Cost/Share $0.88 Unrealized @ Report Date —
QTI QT IMAGING HLDGS INC 0.2%
Value $407K Shares 100,000 Share Price $4.07 Est. Cost/Share $4.07 Unrealized @ Report Date —
SINT SINTX TECHNOLOGIES INC 0.2%
Value $333K Shares 209,205 Share Price $1.59 Est. Cost/Share $1.59 Unrealized @ Report Date —
CLRB CELLECTAR BIOSCIENCES INC 0.2%
Value $291K Shares 104,550 Share Price $2.78 Est. Cost/Share $2.78 Unrealized @ Report Date —
EPRX EUPRAXIA PHARMACEUTICALS INC 0.2%
Value $287K Shares 43,491 Share Price $6.61 Est. Cost/Share $6.61 Unrealized @ Report Date —
ANL ADLAI NORTYE LTD 0.2%
Value $279K Shares 24,257 Share Price $11.50 Est. Cost/Share $11.50 Unrealized @ Report Date —
SENS SENSEONICS HLDGS INC 0.2%
Value $277K Shares 48,680 Share Price $5.68 Est. Cost/Share $5.68 Unrealized @ Report Date —
RNTX REIN THERAPEUTICS INC 0.1%
Value $227K Shares 218,038 Share Price $1.04 Est. Cost/Share $1.04 Unrealized @ Report Date —
HUMA HUMACYTE INC 0.1%
Value $181K Shares 231,299 Share Price $0.78 Est. Cost/Share $0.78 Unrealized @ Report Date —
BCAB BIOATLA INC 0.0%
Value $68,028 Shares 16,432 Share Price $4.14 Est. Cost/Share $4.14 Unrealized @ Report Date —

Increased Positions (23)

VSTM VERASTEM INC 7.2%
Value $12.8M (-26.9%) Shares 3,349,627 (+1.4%) Share Price $3.82 Est. Cost/Share $6.13 Unrealized @ Report Date —
MSLE SATELLOS BIOSCIENCE INC 2.1%
Value $3.723M (+561.3%) Shares 491,624 (+391.6%) Share Price $7.57 Est. Cost/Share $7.18 Unrealized @ Report Date —
EDSA EDESA BIOTECH INC 1.8%
Value $3.191M (+1933.7%) Shares 456,439 (+1421.5%) Share Price $6.99 Est. Cost/Share $6.68 Unrealized @ Report Date —
CABA CABALETTA BIO INC 1.6%
Value $2.852M (+2020.6%) Shares 917,100 (+1734.2%) Share Price $3.11 Est. Cost/Share $3.08 Unrealized @ Report Date —
NKTR NEKTAR THERAPEUTICS 4.8%
Value $8.423M (+37.7%) Shares 120,654 (+41.9%) Share Price $69.81 Est. Cost/Share $34.85 Unrealized @ Report Date —
XLO XILIO THERAPEUTICS INC 1.2%
Value $2.165M (+301.2%) Shares 225,994 (+252.2%) Share Price $9.58 Est. Cost/Share $9.25 Unrealized @ Report Date —
QNRX QUOIN PHARMACEUTICALS LTD 0.5%
Value $966K (+173.6%) Shares 199,486 (+273.2%) Share Price $4.84 Est. Cost/Share $7.41 Unrealized @ Report Date —
ACET ADICET BIO INC 1.2%
Value $2.121M (+40.3%) Shares 245,518 (+10.6%) Share Price $8.64 Est. Cost/Share $10.82 Unrealized @ Report Date —
KTTA PASITHEA THERAPEUTICS CORP 0.6%
Value $1.135M (+84.0%) Shares 2,201,468 (+164.8%) Share Price $0.52 Est. Cost/Share $0.65 Unrealized @ Report Date —
CRBP CORBUS PHARMACEUTICALS HLDGS 2.2%
Value $3.986M (+10.7%) Shares 425,000 (+10.8%) Share Price $9.38 Est. Cost/Share $12.05 Unrealized @ Report Date —
TELA TELA BIO INC 1.1%
Value $1.997M (+23.1%) Shares 2,662,427 (+1.7%) Share Price $0.75 Est. Cost/Share $3.67 Unrealized @ Report Date —
PHAT PHATHOM PHARMACEUTICALS INC 0.5%
Value $922K (+66.0%) Shares 85,010 (+70.0%) Share Price $10.85 Est. Cost/Share $12.52 Unrealized @ Report Date —
ARVN ARVINAS INC 0.3%
Value $499K (+71.0%) Shares 60,000 (+118.2%) Share Price $8.31 Est. Cost/Share $10.26 Unrealized @ Report Date —
AYTU AYTU BIOPHARMA INC 1.1%
Value $1.963M (-9.3%) Shares 912,921 (+15.2%) Share Price $2.15 Est. Cost/Share $1.86 Unrealized @ Report Date —
CTMX CYTOMX THERAPEUTICS INC. 0.4%
Value $769K (-18.2%) Shares 205,000 (+2.5%) Share Price $3.75 Est. Cost/Share $5.19 Unrealized @ Report Date —
IRD OPUS GENETICS INC 0.2%
Value $414K (+32.5%) Shares 100,718 (+46.6%) Share Price $4.11 Est. Cost/Share $3.18 Unrealized @ Report Date —
SABS SAB BIOTHERAPEUTICS INC 0.2%
Value $286K (+49.2%) Shares 73,271 (+46.5%) Share Price $3.90 Est. Cost/Share $3.97 Unrealized @ Report Date —
OKYO OKYO PHARMA LTD 0.7%
Value $1.294M (-5.4%) Shares 862,996 (+1.5%) Share Price $1.50 Est. Cost/Share $2.11 Unrealized @ Report Date —
LUNG PULMONX CORP 0.6%
Value $1.06M (+7.0%) Shares 815,436 (+6.1%) Share Price $1.30 Est. Cost/Share $2.16 Unrealized @ Report Date —
CNTB CONNECT BIOPHARMA HLDGS LTD 0.5%
Value $867K (+6.7%) Shares 364,254 (+17.5%) Share Price $2.38 Est. Cost/Share $2.46 Unrealized @ Report Date —
PLRX PLIANT THERAPEUTICS INC 0.1%
Value $263K (-7.2%) Shares 230,538 (+2.6%) Share Price $1.14 Est. Cost/Share $1.52 Unrealized @ Report Date —
KLRS KALARIS THERAPEUTICS INC 0.1%
Value $123K (+4.2%) Shares 30,122 (+47.7%) Share Price $4.07 Est. Cost/Share $7.66 Unrealized @ Report Date —
INAB IN8BIO INC 0.6%
Value $980K (-0.2%) Shares 695,287 (+4.8%) Share Price $1.41 Est. Cost/Share $2.28 Unrealized @ Report Date —

Exited Positions (21)

XBI SPDR SERIES TRUST 28.8%
Value $51.09M Shares 400,000 Share Price $127.73 Est. Cost/Share — Unrealized @ Report Date —
XBI SPDR SERIES TRUST 28.8%
Value $51.09M Shares 400,000 Share Price $127.73 Est. Cost/Share — Unrealized @ Report Date —
TERN TERNS PHARMACEUTICALS INC 3.0%
Value $5.272M Shares 100,000 Share Price $52.72 Est. Cost/Share — Unrealized @ Report Date —
ESTA ESTABLISHMENT LABS HLDGS INC 1.6%
Value $2.839M Shares 50,000 Share Price $56.78 Est. Cost/Share $70.34 Unrealized @ Report Date —
ARE ALEXANDRIA REAL ESTATE EQ IN 1.3%
Value $2.321M Shares 50,000 Share Price $46.42 Est. Cost/Share — Unrealized @ Report Date —
ACAD ACADIA PHARMACEUTICALS INC 1.3%
Value $2.226M Shares 100,000 Share Price $22.26 Est. Cost/Share — Unrealized @ Report Date —
XOMA XOMA ROYALTY CORPORATION 1.2%
Value $2.18M Shares 69,500 Share Price $31.37 Est. Cost/Share $20.48 Unrealized @ Report Date —
SRZN SURROZEN INC 0.5%
Value $961K Shares 33,005 Share Price $29.13 Est. Cost/Share $10.69 Unrealized @ Report Date —
CTMX CYTOMX THERAPEUTICS INC. 0.5%
Value $940K Shares 200,000 Share Price $4.70 Est. Cost/Share $5.19 Unrealized @ Report Date —
VRCA VERRICA PHARMACEUTICALS INC 0.3%
Value $528K Shares 99,735 Share Price $5.29 Est. Cost/Share $5.54 Unrealized @ Report Date —
CADL CANDEL THERAPEUTICS INC 0.3%
Value $502K Shares 102,500 Share Price $4.90 Est. Cost/Share $5.74 Unrealized @ Report Date —
ABEO ABEONA THERAPEUTICS INC 0.3%
Value $448K Shares 100,000 Share Price $4.48 Est. Cost/Share $5.79 Unrealized @ Report Date —
ESTA ESTABLISHMENT LABS HLDGS INC 0.2%
Value $341K Shares 6,000 Share Price $56.78 Est. Cost/Share $70.34 Unrealized @ Report Date —
JANX JANUX THERAPEUTICS INC 0.2%
Value $278K Shares 20,000 Share Price $13.90 Est. Cost/Share $23.52 Unrealized @ Report Date —
OABI OMNIAB INC 0.1%
Value $258K Shares 164,045 Share Price $1.57 Est. Cost/Share $1.83 Unrealized @ Report Date —
XERS XERIS BIOPHARMA HOLDINGS INC 0.1%
Value $232K Shares 40,030 Share Price $5.80 Est. Cost/Share $7.21 Unrealized @ Report Date —
NMRA NEUMORA THERAPEUTICS INC. 0.1%
Value $195K Shares 100,000 Share Price $1.95 Est. Cost/Share $2.46 Unrealized @ Report Date —
SIBN SI BONE INC 0.1%
Value $189K Shares 14,964 Share Price $12.63 Est. Cost/Share $16.92 Unrealized @ Report Date —
ELDN ELEDON PHARMACEUTICALS INC 0.1%
Value $108K Shares 35,000 Share Price $3.08 Est. Cost/Share $2.38 Unrealized @ Report Date —
MNKD MANNKIND CORP 0.0%
Value $39,935 Shares 16,300 Share Price $2.45 Est. Cost/Share $4.39 Unrealized @ Report Date —
BCAB BIOATLA INC 0.0%
Value $10,527 Shares 65,387 Share Price $0.16 Est. Cost/Share $0.27 Unrealized @ Report Date —

Decreased Positions (27)

TENX TENAX THERAPEUTICS INC 5.4%
Value $9.603M (-38.4%) Shares 660,000 (-32.3%) Share Price $14.55 Est. Cost/Share $13.44 Unrealized @ Report Date —
EOLS EVOLUS INC 6.2%
Value $11.04M (+52.6%) Shares 1,590,162 (-9.6%) Share Price $6.94 Est. Cost/Share $7.98 Unrealized @ Report Date —
ADMA ADMA BIOLOGICS INC 4.5%
Value $7.95M (-23.3%) Shares 650,000 (-43.5%) Share Price $12.23 Est. Cost/Share $2.26 Unrealized @ Report Date —
SLGL SOL-GEL TECHNOLOGIES LTD 0.6%
Value $1.073M (-51.3%) Shares 14,469 (-47.9%) Share Price $74.14 Est. Cost/Share $66.40 Unrealized @ Report Date —
HRTX HERON THERAPEUTICS INC 0.1%
Value $209K (-81.3%) Shares 490,787 (-65.0%) Share Price $0.43 Est. Cost/Share $1.49 Unrealized @ Report Date —
CBIO CRESCENT BIOPHARMA INC. 0.4%
Value $720K (-53.9%) Shares 40,000 (-52.9%) Share Price $18.00 Est. Cost/Share $12.74 Unrealized @ Report Date —
IKT INHIBIKASE THERAPEUTICS INC 0.5%
Value $804K (-50.0%) Shares 396,179 (-58.6%) Share Price $2.03 Est. Cost/Share $1.87 Unrealized @ Report Date —
ZVRA ZEVRA THERAPEUTICS INC 2.1%
Value $3.71M (-17.1%) Shares 258,701 (-46.1%) Share Price $14.34 Est. Cost/Share $7.20 Unrealized @ Report Date —
MNKD MANNKIND CORP 0.4%
Value $750K (-38.8%) Shares 250,000 (-50.0%) Share Price $3.00 Est. Cost/Share $4.39 Unrealized @ Report Date —
CDXS CODEXIS INC 0.1%
Value $248K (-63.6%) Shares 109,662 (-73.8%) Share Price $2.26 Est. Cost/Share $1.95 Unrealized @ Report Date —
BIOA BIOAGE LABS INC 0.3%
Value $490K (-43.9%) Shares 20,000 (-60.0%) Share Price $24.51 Est. Cost/Share $5.81 Unrealized @ Report Date —
XFOR X4 PHARMACEUTICALS INC 0.6%
Value $1.051M (-24.1%) Shares 224,989 (-32.9%) Share Price $4.67 Est. Cost/Share $2.58 Unrealized @ Report Date —
CRIS CURIS INC 1.0%
Value $1.729M (-15.2%) Shares 3,312,185 (-11.1%) Share Price $0.52 Est. Cost/Share $0.98 Unrealized @ Report Date —
BOLD BOUNDLESS BIO INC 0.2%
Value $386K (-41.2%) Shares 154,595 (-74.1%) Share Price $2.50 Est. Cost/Share $1.22 Unrealized @ Report Date —
ANTX AN2 THERAPEUTICS INC 1.5%
Value $2.67M (+9.4%) Shares 551,692 (-22.7%) Share Price $4.84 Est. Cost/Share $1.18 Unrealized @ Report Date —
MXCT MAXCYTE INC 0.5%
Value $924K (+31.0%) Shares 751,606 (-25.2%) Share Price $1.23 Est. Cost/Share $1.36 Unrealized @ Report Date —
HELP CYBIN INC 0.5%
Value $855K (+32.8%) Shares 129,280 (-3.6%) Share Price $6.61 Est. Cost/Share $6.44 Unrealized @ Report Date —
POCI PRECISION OPTICS CORP INC MA 0.1%
Value $237K (-46.1%) Shares 46,390 (-53.6%) Share Price $5.10 Est. Cost/Share $4.74 Unrealized @ Report Date —
PMVP PMV PHARMACEUTICALS INC 0.4%
Value $718K (-18.2%) Shares 536,086 (-24.3%) Share Price $1.34 Est. Cost/Share $1.40 Unrealized @ Report Date —
CGEN COMPUGEN LTD 0.0%
Value $67,168 (-69.8%) Shares 31,387 (-69.9%) Share Price $2.14 Est. Cost/Share $1.66 Unrealized @ Report Date —
ZNTL ZENTALIS PHARMACEUTICALS INC 0.4%
Value $784K (+24.5%) Shares 161,583 (-40.0%) Share Price $4.85 Est. Cost/Share $1.56 Unrealized @ Report Date —
ABEO ABEONA THERAPEUTICS INC 1.9%
Value $3.444M (+3.0%) Shares 557,284 (-25.4%) Share Price $6.18 Est. Cost/Share $5.79 Unrealized @ Report Date —
UPB UPSTREAM BIO INC 0.1%
Value $231K (-26.6%) Shares 33,432 (-4.5%) Share Price $6.92 Est. Cost/Share $23.68 Unrealized @ Report Date —
CNSP CNS PHARMACEUTICALS INC 0.1%
Value $199K (+36.3%) Shares 41,573 (-31.8%) Share Price $4.78 Est. Cost/Share $7.00 Unrealized @ Report Date —
OKUR ONKURE THERAPEUTICS INC 0.3%
Value $596K (+8.6%) Shares 130,684 (-1.4%) Share Price $4.56 Est. Cost/Share $2.73 Unrealized @ Report Date —
OVID OVID THERAPEUTICS INC 0.0%
Value $57,297 (-35.5%) Shares 21,300 (-46.8%) Share Price $2.69 Est. Cost/Share $1.54 Unrealized @ Report Date —
EVAX EVAXION AS 0.0%
Value $54,442 (-25.8%) Shares 17,562 (-10.9%) Share Price $3.10 Est. Cost/Share $4.77 Unrealized @ Report Date —

Unchanged Positions (12)

KZIA KAZIA THERAPEUTICS LTD 2.7%
Value $4.86M Shares 345,179 Share Price $14.08 Est. Cost/Share $6.89 Unrealized @ Report Date —
EOLS EVOLUS INC 1.8%
Value $3.15M Shares 420,000 Share Price $7.50 Est. Cost/Share $7.98 Unrealized @ Report Date —
HRTX HERON THERAPEUTICS INC 0.8%
Value $1.5M Shares 1,000,000 Share Price $1.50 Est. Cost/Share $1.49 Unrealized @ Report Date —
XERS XERIS BIOPHARMA HOLDINGS INC 1.2%
Value $2.1M Shares 280,000 Share Price $7.50 Est. Cost/Share $7.21 Unrealized @ Report Date —
ADMA ADMA BIOLOGICS INC 3.5%
Value $6.194M Shares 740,000 Share Price $8.37 Est. Cost/Share $2.26 Unrealized @ Report Date —
NMRA NEUMORA THERAPEUTICS INC. 0.7%
Value $1.25M Shares 500,000 Share Price $2.50 Est. Cost/Share $2.46 Unrealized @ Report Date —
SIBN SI BONE INC 0.8%
Value $1.5M Shares 100,000 Share Price $15.00 Est. Cost/Share $16.92 Unrealized @ Report Date —
ARDX ARDELYX INC 0.6%
Value $1.05M Shares 150,000 Share Price $7.00 Est. Cost/Share — Unrealized @ Report Date —
DCTH DELCATH SYS INC 0.6%
Value $1M Shares 100,000 Share Price $10.00 Est. Cost/Share — Unrealized @ Report Date —
RADX RADIOPHARM THERANOSTICS LTD 0.4%
Value $671K Shares 51,000,000 Share Price $0.01 Est. Cost/Share $0.02 Unrealized @ Report Date —
CAMP CAMP4 THERAPEUTICS CORP 3.4%
Value $6.073M Shares 1,389,622 Share Price $4.37 Est. Cost/Share $4.60 Unrealized @ Report Date —
PCSA PROCESSA PHARMACEUTICALS INC 0.1%
Value $106K Shares 55,000 Share Price $1.92 Est. Cost/Share $3.72 Unrealized @ Report Date —