EcoR1 Capital, LLC Quant / Systematic

Location: San Francisco, CA

CIK: 0001587114 · Show all filings

Period: Q3 2019 (← Previous) (Next →)

Filing Date: Nov 14, 2019

Total Value: $792M (100.0% shares, 0.0% debt)

Holdings (38)

XNCR XENCOR ORD 10.7%

Value $84.38M Shares 2,501,557 Est. Cost $35.02 Unrealized +14.0%

PRTA PROTHENA ORD 9.3%

Value $73.91M Shares 9,426,640 Est. Cost $9.11 Unrealized -2.5%

— SPARK THERAPEUTICS ORD 8.8%

Value $69.32M Shares 714,789 Est. Cost $63.21 Unrealized —

KURA KURA ONCOLOGY ORD 7.7%

Value $61.32M Shares 4,041,953 Est. Cost $10.87 Unrealized +63.7%

ARGX ARGENX ADR REP ORD 7.6%

Value $60.53M Shares 531,165 Est. Cost $96.07 Unrealized —

— DICERNA PHARMACEUTICALS ORD 7.2%

Value $56.91M Shares 3,962,978 Est. Cost $10.37 Unrealized —

— FIBROGEN ORD 6.0%

Value $47.84M Shares 1,293,807 Est. Cost $44.16 Unrealized —

IRWD IRONWOOD PHARMA CL A ORD 5.1%

Value $40.1M Shares 4,671,408 Est. Cost $11.82 Unrealized -17.8%

— MORPHIC HOLDING ORD 4.9%

Value $39.15M Shares 2,161,520 Est. Cost $19.82 Unrealized —

— SOLID BIOSCIENCES ORD 4.4%

Value $34.56M Shares 3,342,691 Est. Cost $9.20 Unrealized —

— PREVAIL THERAPEUTICS ORD 3.7%

Value $29.38M Shares 2,392,556 Est. Cost $13.20 Unrealized —

— FIBROGEN ORD 3.0%

Value $24.13M Shares 652,500 Est. Cost $44.16 Unrealized —

— HARPOON THERAPEUTICS ORD 2.5%

Value $19.99M Shares 1,463,423 Est. Cost $9.80 Unrealized —

— ATRECA CL A ORD 2.3%

Value $18.13M Shares 1,481,411 Est. Cost $18.84 Unrealized —

— CHIASMA ORD 1.9%

Value $15.07M Shares 3,043,827 Est. Cost $5.00 Unrealized —

SRPT SAREPTA THERAPEUTICS ORD 1.8%

Value $14.29M Shares 189,745 Est. Cost $118.10 Unrealized 0.0%

— EXICURE ORD 1.8%

Value $13.95M Shares 5,515,225 Est. Cost $2.53 Unrealized —

GOSS GOSSAMER BIO INC ORD 1.7%

Value $13.43M Shares 800,000 Est. Cost $20.85 Unrealized -4.6%

— EIGER BIOPHARMACEUTICAL ORD 1.4%

Value $10.87M Shares 1,060,043 Est. Cost $11.49 Unrealized —

— CYCLERION THERAPEUTICS ORD 1.2%

Value $9.408M Shares 776,206 Est. Cost $11.45 Unrealized —

— NEXTCURE ORD 1.0%

Value $7.728M Shares 250,500 Est. Cost $30.85 Unrealized —

RCUS ARCUS BIOSCIENCES ORD 0.9%

Value $6.866M Shares 754,505 Est. Cost $14.43 Unrealized -44.3%

— CURIS ORD 0.8%

Value $6.68M Shares 2,982,208 Est. Cost $0.69 Unrealized —

— NEOLEUKIN THERAPEUTICS ORD 0.8%

Value $6.458M Shares 2,265,880 Est. Cost $2.85 Unrealized —

— ASSEMBLY BIOSCIENCES ORD 0.6%

Value $4.898M Shares 498,300 Est. Cost $9.83 Unrealized —

— MIRATI THERAPEUTICS ORD 0.4%

Value $3.445M Shares 44,221 Est. Cost $53.32 Unrealized —

— MERUS ORD 0.4%

Value $2.951M Shares 165,600 Est. Cost $17.82 Unrealized —

RARE ULTRAGENYX PHARMACEUTICAL ORD 0.3%

Value $2.633M Shares 61,554 Est. Cost $57.14 Unrealized -4.9%

— SURFACE ONCOLOGY ORD 0.3%

Value $2.199M Shares 1,548,888 Est. Cost $10.23 Unrealized —

— RUBIUS THERAPEUTICS ORD 0.3%

Value $2.042M Shares 260,152 Est. Cost $23.51 Unrealized —

VCEL VERICEL ORD 0.3%

Value $1.983M Shares 131,001 Est. Cost $18.29 Unrealized -4.3%

— IGM BIOSCIENCES ORD 0.2%

Value $1.775M Shares 100,000 Est. Cost $17.75 Unrealized —

— ZAFGEN ORD 0.2%

Value $1.437M Shares 1,944,500 Est. Cost $0.74 Unrealized —

QNCX CORTEXYME ORD 0.2%

Value $1.246M Shares 49,993 Est. Cost $30.76 Unrealized 0.0%

— ASSEMBLY BIOSCIENCES ORD 0.1%

Value $950K Shares 96,600 Est. Cost $9.83 Unrealized —

AUTL AUTOLUS THERAPEUTICS ADR 0.1%

Value $859K Shares 69,155 Est. Cost $12.42 Unrealized —

— REGULUS THERAPEUTICS ORD 0.1%

Value $755K Shares 1,049,088 Est. Cost $1.25 Unrealized —

— UNITY BIOTECHNOLOGY ORD 0.0%

Value $314K Shares 51,400 Est. Cost $14.33 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
XNCR	XENCOR ORD	2,501,557	$84.38M	10.7%	$35.02	+14.0%	COM	98401F105
PRTA	PROTHENA ORD	9,426,640	$73.91M	9.3%	$9.11	-2.5%	COM	G72800108
—	SPARK THERAPEUTICS ORD	714,789	$69.32M	8.8%	$63.21	—	COM	84652J103
KURA	KURA ONCOLOGY ORD	4,041,953	$61.32M	7.7%	$10.87	+63.7%	COM	50127T109
ARGX	ARGENX ADR REP ORD	531,165	$60.53M	7.6%	$96.07	—	SPONSORED ADR	04016X101
—	DICERNA PHARMACEUTICALS ORD	3,962,978	$56.91M	7.2%	$10.37	—	COM	253031108
—	FIBROGEN ORD	1,293,807	$47.84M	6.0%	$44.16	—	COM	31572Q808
IRWD	IRONWOOD PHARMA CL A ORD	4,671,408	$40.1M	5.1%	$11.82	-17.8%	COM	46333X108
—	MORPHIC HOLDING ORD	2,161,520	$39.15M	4.9%	$19.82	—	COM	61775R105
—	SOLID BIOSCIENCES ORD	3,342,691	$34.56M	4.4%	$9.20	—	COM	83422E105
—	PREVAIL THERAPEUTICS ORD	2,392,556	$29.38M	3.7%	$13.20	—	COM	74140Y101
—	FIBROGEN ORD	652,500	$24.13M	3.0%	$44.16	—	Call	31572Q808
—	HARPOON THERAPEUTICS ORD	1,463,423	$19.99M	2.5%	$9.80	—	COM	41358P106
—	ATRECA CL A ORD	1,481,411	$18.13M	2.3%	$18.84	—	COM	04965G109
—	CHIASMA ORD	3,043,827	$15.07M	1.9%	$5.00	—	COM	16706W102
SRPT	SAREPTA THERAPEUTICS ORD	189,745	$14.29M	1.8%	$118.10	0.0%	COM	803607100
—	EXICURE ORD	5,515,225	$13.95M	1.8%	$2.53	—	COM	30205M101
GOSS	GOSSAMER BIO INC ORD	800,000	$13.43M	1.7%	$20.85	-4.6%	Call	38341P102
—	EIGER BIOPHARMACEUTICAL ORD	1,060,043	$10.87M	1.4%	$11.49	—	COM	28249U105
—	CYCLERION THERAPEUTICS ORD	776,206	$9.408M	1.2%	$11.45	—	COM	23255M105
—	NEXTCURE ORD	250,500	$7.728M	1.0%	$30.85	—	COM	65343E108
RCUS	ARCUS BIOSCIENCES ORD	754,505	$6.866M	0.9%	$14.43	-44.3%	COM	03969F109
—	CURIS ORD	2,982,208	$6.68M	0.8%	$0.69	—	COM	231269200
—	NEOLEUKIN THERAPEUTICS ORD	2,265,880	$6.458M	0.8%	$2.85	—	COM	64049K104
—	ASSEMBLY BIOSCIENCES ORD	498,300	$4.898M	0.6%	$9.83	—	Call	045396108
—	MIRATI THERAPEUTICS ORD	44,221	$3.445M	0.4%	$53.32	—	COM	60468T105
—	MERUS ORD	165,600	$2.951M	0.4%	$17.82	—	COM	N5749R100
RARE	ULTRAGENYX PHARMACEUTICAL ORD	61,554	$2.633M	0.3%	$57.14	-4.9%	COM	90400D108
—	SURFACE ONCOLOGY ORD	1,548,888	$2.199M	0.3%	$10.23	—	COM	86877M209
—	RUBIUS THERAPEUTICS ORD	260,152	$2.042M	0.3%	$23.51	—	COM	78116T103
VCEL	VERICEL ORD	131,001	$1.983M	0.3%	$18.29	-4.3%	COM	92346J108
—	IGM BIOSCIENCES ORD	100,000	$1.775M	0.2%	$17.75	—	COM	449585108
—	ZAFGEN ORD	1,944,500	$1.437M	0.2%	$0.74	—	COM	98885E103
QNCX	CORTEXYME ORD	49,993	$1.246M	0.2%	$30.76	0.0%	COM	22053A107
—	ASSEMBLY BIOSCIENCES ORD	96,600	$950K	0.1%	$9.83	—	COM	045396108
AUTL	AUTOLUS THERAPEUTICS ADR	69,155	$859K	0.1%	$12.42	—	SPONSORED ADR	05280R100
—	REGULUS THERAPEUTICS ORD	1,049,088	$755K	0.1%	$1.25	—	COM	75915K200
—	UNITY BIOTECHNOLOGY ORD	51,400	$314K	0.0%	$14.33	—	COM	91381U101