EcoR1 Capital, LLC Quant / Systematic

Location: San Francisco, CA

CIK: 0001587114 · Show all filings

Period: Q4 2019 (← Previous) (Next →)

Filing Date: Feb 18, 2020

Total Value: $1.109B (100.0% shares, 0.0% debt)

Holdings (44)

PRTA PROTHENA CORP PLC 13.5%

Value $149M Shares 9,426,640 Est. Cost $9.11 Unrealized +17.7%

XNCR XENCOR INC 7.8%

Value $86.03M Shares 2,501,557 Est. Cost $35.02 Unrealized +4.3%

— DICERNA PHARMACEUTICALS INC 7.2%

Value $79.92M Shares 3,627,597 Est. Cost $10.37 Unrealized —

— FIBROGEN INC 5.8%

Value $64M Shares 1,492,221 Est. Cost $43.99 Unrealized —

KURA KURA ONCOLOGY INC 5.3%

Value $58.33M Shares 4,241,953 Est. Cost $11.06 Unrealized +34.0%

IRWD IRONWOOD PHARMACEUTICALS INC 5.2%

Value $58.18M Shares 4,371,408 Est. Cost $11.82 Unrealized -6.7%

ARVN ARVINAS INC 5.0%

Value $55.02M Shares 1,339,069 Est. Cost $29.28 Unrealized 0.0%

— ASSEMBLY BIOSCIENCES INC 4.4%

Value $48.86M Shares 2,388,268 Est. Cost $20.03 Unrealized —

— NEOLEUKIN THERAPEUTICS INC 4.3%

Value $48.24M Shares 3,915,880 Est. Cost $6.84 Unrealized —

— MORPHIC HLDG INC 3.3%

Value $36.98M Shares 2,154,845 Est. Cost $19.82 Unrealized —

— PREVAIL THERAPEUTICS INC 3.2%

Value $35.59M Shares 2,248,306 Est. Cost $13.20 Unrealized —

ARGX ARGENX SE 2.9%

Value $32.44M Shares 202,117 Est. Cost $96.07 Unrealized —

ANAB ANAPTYSBIO INC 2.9%

Value $31.95M Shares 1,966,100 Est. Cost $23.65 Unrealized 0.0%

IPHA INNATE PHARMA S A 2.6%

Value $29.27M Shares 4,545,454 Est. Cost $6.44 Unrealized —

— FIBROGEN INC 2.6%

Value $29.02M Shares 676,500 Est. Cost $43.99 Unrealized —

BMRN BIOMARIN PHARMACEUTICAL INC 2.4%

Value $26.42M Shares 312,500 Est. Cost — Unrealized —

— MERUS N V 2.2%

Value $24.19M Shares 1,718,200 Est. Cost $14.44 Unrealized —

— ATRECA INC 2.1%

Value $22.92M Shares 1,481,411 Est. Cost $18.84 Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 1.9%

Value $21.39M Shares 500,000 Est. Cost $43.50 Unrealized 0.0%

— CHIASMA INC 1.4%

Value $15.1M Shares 3,043,827 Est. Cost $5.00 Unrealized —

— HARPOON THERAPEUTICS INC 1.2%

Value $13.44M Shares 908,547 Est. Cost $9.80 Unrealized —

— SAGE THERAPEUTICS INC 1.1%

Value $12.52M Shares 173,364 Est. Cost $72.19 Unrealized —

RARE ULTRAGENYX PHARMACEUTICAL IN 1.0%

Value $11.17M Shares 261,554 Est. Cost $45.00 Unrealized -8.3%

— SELECTA BIOSCIENCES INC 1.0%

Value $10.94M Shares 4,597,701 Est. Cost $2.38 Unrealized —

— EXICURE INC 0.9%

Value $10.14M Shares 3,544,186 Est. Cost $2.53 Unrealized —

— PIERIS PHARMACEUTICALS INC 0.8%

Value $9.177M Shares 2,535,212 Est. Cost $3.62 Unrealized —

FATE FATE THERAPEUTICS INC 0.8%

Value $8.833M Shares 451,354 Est. Cost $15.88 Unrealized 0.0%

— MIRATI THERAPEUTICS INC 0.8%

Value $8.376M Shares 65,000 Est. Cost $77.47 Unrealized —

RCUS ARCUS BIOSCIENCES INC 0.7%

Value $7.372M Shares 729,905 Est. Cost $14.43 Unrealized -41.7%

EOLS EVOLUS INC 0.7%

Value $7.302M Shares 600,000 Est. Cost $14.10 Unrealized 0.0%

— EIGER BIOPHARMACEUTICALS INC 0.6%

Value $6.695M Shares 449,338 Est. Cost $11.49 Unrealized —

SVRA SAVARA INC 0.6%

Value $6.418M Shares 1,432,664 Est. Cost $1.20 Unrealized 0.0%

IOVA IOVANCE BIOTHERAPEUTICS INC 0.5%

Value $5.914M Shares 213,647 Est. Cost $22.75 Unrealized 0.0%

— RUBIUS THERAPEUTICS INC 0.5%

Value $4.996M Shares 525,877 Est. Cost $16.43 Unrealized —

— CYCLERION THERAPEUTICS INC 0.4%

Value $4.926M Shares 1,811,000 Est. Cost $6.46 Unrealized —

— X4 PHARMACEUTICALS INC 0.4%

Value $4.445M Shares 415,400 Est. Cost $10.70 Unrealized —

CRVS CORVUS PHARMACEUTICALS INC 0.4%

Value $4.013M Shares 737,612 Est. Cost $3.50 Unrealized 0.0%

ACRS ACLARIS THERAPEUTICS INC 0.4%

Value $3.945M Shares 2,087,312 Est. Cost $1.66 Unrealized 0.0%

— IGM BIOSCIENCES INC 0.3%

Value $3.816M Shares 100,000 Est. Cost $17.75 Unrealized —

— TCR2 THERAPEUTICS INC 0.3%

Value $3.42M Shares 239,500 Est. Cost $14.28 Unrealized —

CTMX CYTOMX THERAPEUTICS INC 0.3%

Value $3.407M Shares 410,000 Est. Cost $6.75 Unrealized 0.0%

— SURFACE ONCOLOGY INC 0.2%

Value $2.447M Shares 1,301,713 Est. Cost $10.23 Unrealized —

VCEL VERICEL CORP 0.2%

Value $2.279M Shares 131,001 Est. Cost $18.29 Unrealized -6.9%

UROV UROVANT SCIENCES LTD 0.0%

Value $411K Shares 26,468 Est. Cost $15.53 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
PRTA	PROTHENA CORP PLC	9,426,640	$149M	13.5%	$9.11	+17.7%	SHS	G72800108
XNCR	XENCOR INC	2,501,557	$86.03M	7.8%	$35.02	+4.3%	COM	98401F105
—	DICERNA PHARMACEUTICALS INC	3,627,597	$79.92M	7.2%	$10.37	—	COM	253031108
—	FIBROGEN INC	1,492,221	$64M	5.8%	$43.99	—	COM	31572Q808
KURA	KURA ONCOLOGY INC	4,241,953	$58.33M	5.3%	$11.06	+34.0%	COM	50127T109
IRWD	IRONWOOD PHARMACEUTICALS INC	4,371,408	$58.18M	5.2%	$11.82	-6.7%	COM CL A	46333X108
ARVN	ARVINAS INC	1,339,069	$55.02M	5.0%	$29.28	0.0%	COM	04335A105
—	ASSEMBLY BIOSCIENCES INC	2,388,268	$48.86M	4.4%	$20.03	—	COM	045396108
—	NEOLEUKIN THERAPEUTICS INC	3,915,880	$48.24M	4.3%	$6.84	—	COM	64049K104
—	MORPHIC HLDG INC	2,154,845	$36.98M	3.3%	$19.82	—	COM	61775R105
—	PREVAIL THERAPEUTICS INC	2,248,306	$35.59M	3.2%	$13.20	—	COM	74140Y101
ARGX	ARGENX SE	202,117	$32.44M	2.9%	$96.07	—	SPONSORED ADR	04016X101
ANAB	ANAPTYSBIO INC	1,966,100	$31.95M	2.9%	$23.65	0.0%	COM	032724106
IPHA	INNATE PHARMA S A	4,545,454	$29.27M	2.6%	$6.44	—	SPONSORED ADS	45781K204
—	FIBROGEN INC	676,500	$29.02M	2.6%	$43.99	—	Call	31572Q808
BMRN	BIOMARIN PHARMACEUTICAL INC	312,500	$26.42M	2.4%	—	—	Call	09061G101
—	MERUS N V	1,718,200	$24.19M	2.2%	$14.44	—	COM	N5749R100
—	ATRECA INC	1,481,411	$22.92M	2.1%	$18.84	—	CL A COM	04965G109
ACAD	ACADIA PHARMACEUTICALS INC	500,000	$21.39M	1.9%	$43.50	0.0%	COM	004225108
—	CHIASMA INC	3,043,827	$15.1M	1.4%	$5.00	—	COM	16706W102
—	HARPOON THERAPEUTICS INC	908,547	$13.44M	1.2%	$9.80	—	COM	41358P106
—	SAGE THERAPEUTICS INC	173,364	$12.52M	1.1%	$72.19	—	COM	78667J108
RARE	ULTRAGENYX PHARMACEUTICAL IN	261,554	$11.17M	1.0%	$45.00	-8.3%	COM	90400D108
—	SELECTA BIOSCIENCES INC	4,597,701	$10.94M	1.0%	$2.38	—	COM	816212104
—	EXICURE INC	3,544,186	$10.14M	0.9%	$2.53	—	COM	30205M101
—	PIERIS PHARMACEUTICALS INC	2,535,212	$9.177M	0.8%	$3.62	—	COM	720795103
FATE	FATE THERAPEUTICS INC	451,354	$8.833M	0.8%	$15.88	0.0%	COM	31189P102
—	MIRATI THERAPEUTICS INC	65,000	$8.376M	0.8%	$77.47	—	COM	60468T105
RCUS	ARCUS BIOSCIENCES INC	729,905	$7.372M	0.7%	$14.43	-41.7%	COM	03969F109
EOLS	EVOLUS INC	600,000	$7.302M	0.7%	$14.10	0.0%	COM	30052C107
—	EIGER BIOPHARMACEUTICALS INC	449,338	$6.695M	0.6%	$11.49	—	COM	28249U105
SVRA	SAVARA INC	1,432,664	$6.418M	0.6%	$1.20	0.0%	COM	805111101
IOVA	IOVANCE BIOTHERAPEUTICS INC	213,647	$5.914M	0.5%	$22.75	0.0%	COM	462260100
—	RUBIUS THERAPEUTICS INC	525,877	$4.996M	0.5%	$16.43	—	COM	78116T103
—	CYCLERION THERAPEUTICS INC	1,811,000	$4.926M	0.4%	$6.46	—	COM	23255M105
—	X4 PHARMACEUTICALS INC	415,400	$4.445M	0.4%	$10.70	—	COM	98420X103
CRVS	CORVUS PHARMACEUTICALS INC	737,612	$4.013M	0.4%	$3.50	0.0%	COM	221015100
ACRS	ACLARIS THERAPEUTICS INC	2,087,312	$3.945M	0.4%	$1.66	0.0%	COM	00461U105
—	IGM BIOSCIENCES INC	100,000	$3.816M	0.3%	$17.75	—	COM	449585108
—	TCR2 THERAPEUTICS INC	239,500	$3.42M	0.3%	$14.28	—	COM	87808K106
CTMX	CYTOMX THERAPEUTICS INC	410,000	$3.407M	0.3%	$6.75	0.0%	COM	23284F105
—	SURFACE ONCOLOGY INC	1,301,713	$2.447M	0.2%	$10.23	—	COM	86877M209
VCEL	VERICEL CORP	131,001	$2.279M	0.2%	$18.29	-6.9%	COM	92346J108
UROV	UROVANT SCIENCES LTD	26,468	$411K	0.0%	$15.53	—	SHS	G9381B108