EcoR1 Capital, LLC Quant / Systematic

Location: San Francisco, CA

CIK: 0001587114 · Show all filings

Period: Q2 2019 (← Previous) (Next →)

Filing Date: Aug 14, 2019

Total Value: $990M (100.0% shares, 0.0% debt)

Holdings (39)

KURA KURA ONCOLOGY ORD 10.5%

Value $104M Shares 5,276,753 Est. Cost $10.87 Unrealized +52.7%

XNCR XENCOR ORD 9.7%

Value $95.64M Shares 2,336,557 Est. Cost $34.67 Unrealized -5.2%

ARGX ARGENX ADR REP ORD 8.3%

Value $82.28M Shares 581,165 Est. Cost $96.07 Unrealized —

CRSP CRISPR THERAPEUTICS ORD 7.7%

Value $75.84M Shares 1,610,250 Est. Cost $36.55 Unrealized +9.3%

— FIBROGEN ORD 6.9%

Value $68.3M Shares 1,511,785 Est. Cost $44.16 Unrealized —

— SPARK THERAPEUTICS ORD 6.4%

Value $62.87M Shares 614,128 Est. Cost $57.68 Unrealized —

— MIRATI THERAPEUTICS ORD 6.2%

Value $61.56M Shares 597,711 Est. Cost $53.32 Unrealized —

— DICERNA PHARMACEUTICALS ORD 5.3%

Value $52.23M Shares 3,316,407 Est. Cost $9.60 Unrealized —

IRWD IRONWOOD PHARMA CL A ORD 5.2%

Value $51.1M Shares 4,671,408 Est. Cost $11.82 Unrealized -5.2%

— MORPHIC HOLDING ORD 4.5%

Value $44.93M Shares 2,266,804 Est. Cost $19.82 Unrealized —

RARE ULTRAGENYX PHARMACEUTICAL ORD 3.2%

Value $31.62M Shares 497,899 Est. Cost $57.14 Unrealized +11.4%

— PREVAIL THERAPEUTICS ORD 3.2%

Value $31.58M Shares 2,392,556 Est. Cost $13.20 Unrealized —

— ATRECA CL A ORD 2.8%

Value $28.02M Shares 1,486,979 Est. Cost $18.84 Unrealized —

— CHIASMA ORD 2.3%

Value $22.74M Shares 3,043,827 Est. Cost $5.00 Unrealized —

— HARPOON THERAPEUTICS ORD 1.8%

Value $17.53M Shares 1,348,423 Est. Cost $9.47 Unrealized —

GOSS GOSSAMER BIO INC ORD 1.7%

Value $17.13M Shares 772,096 Est. Cost $20.85 Unrealized -8.3%

— ARQULE ORD 1.4%

Value $14.31M Shares 1,300,000 Est. Cost $11.01 Unrealized —

— FIBROGEN ORD 1.3%

Value $12.54M Shares 277,500 Est. Cost $44.16 Unrealized —

— EIGER BIOPHARMACEUTICAL ORD 1.2%

Value $12.04M Shares 1,136,043 Est. Cost $11.49 Unrealized —

RCUS ARCUS BIOSCIENCES ORD 1.2%

Value $11.79M Shares 1,488,205 Est. Cost $14.43 Unrealized -30.6%

— UNITY BIOTECHNOLOGY ORD 1.0%

Value $9.923M Shares 1,044,500 Est. Cost $14.33 Unrealized —

— CYCLERION THERAPEUTICS ORD 0.9%

Value $8.888M Shares 776,206 Est. Cost $11.45 Unrealized —

PRTA PROTHENA ORD 0.8%

Value $7.645M Shares 723,300 Est. Cost $11.89 Unrealized -13.6%

— RUBIUS THERAPEUTICS ORD 0.7%

Value $7.285M Shares 463,152 Est. Cost $23.51 Unrealized —

— ASSEMBLY BIOSCIENCES ORD 0.7%

Value $6.723M Shares 498,300 Est. Cost $8.38 Unrealized —

— SURFACE ONCOLOGY ORD 0.7%

Value $6.522M Shares 2,312,688 Est. Cost $10.23 Unrealized —

— MERSANA THERAPEUTICS ORD 0.6%

Value $5.639M Shares 1,392,231 Est. Cost $5.26 Unrealized —

— CURIS ORD 0.6%

Value $5.547M Shares 2,982,208 Est. Cost $0.69 Unrealized —

— AQUINOX PHARMACEUTICALS ORD 0.5%

Value $5.347M Shares 2,265,880 Est. Cost $2.79 Unrealized —

RYTM RHYTHM PHARMACEUTICALS ORD 0.5%

Value $4.91M Shares 223,167 Est. Cost $27.64 Unrealized -8.6%

— SOLID BIOSCIENCES ORD 0.5%

Value $4.755M Shares 827,000 Est. Cost $5.75 Unrealized —

— NGM BIOPHARMACEUTICALS ORD 0.5%

Value $4.639M Shares 316,900 Est. Cost $14.64 Unrealized —

— KEZAR LIFE SCIENCES ORD 0.5%

Value $4.497M Shares 583,293 Est. Cost $17.35 Unrealized —

— ADURO BIOTECH ORD 0.3%

Value $2.713M Shares 1,761,421 Est. Cost $3.98 Unrealized —

VCEL VERICEL ORD 0.3%

Value $2.475M Shares 131,001 Est. Cost $18.29 Unrealized -6.8%

— SYROS PHARMACEUTICALS ORD 0.2%

Value $2.301M Shares 248,480 Est. Cost $9.26 Unrealized —

— REGULUS THERAPEUTICS 0.1%

Value $1.389M Shares 1,111,110 Est. Cost $1.25 Unrealized —

— GAMIDA CELL ORD 0.0%

Value $265K Shares 52,120 Est. Cost $5.08 Unrealized —

— TCR2 THERAPEUTICS ORD 0.0%

Value $231K Shares 16,114 Est. Cost $14.34 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
KURA	KURA ONCOLOGY ORD	5,276,753	$104M	10.5%	$10.87	+52.7%	COM	50127T109
XNCR	XENCOR ORD	2,336,557	$95.64M	9.7%	$34.67	-5.2%	COM	98401F105
ARGX	ARGENX ADR REP ORD	581,165	$82.28M	8.3%	$96.07	—	SPONSORED ADR	04016X101
CRSP	CRISPR THERAPEUTICS ORD	1,610,250	$75.84M	7.7%	$36.55	+9.3%	COM	H17182108
—	FIBROGEN ORD	1,511,785	$68.3M	6.9%	$44.16	—	COM	31572Q808
—	SPARK THERAPEUTICS ORD	614,128	$62.87M	6.4%	$57.68	—	COM	84652J103
—	MIRATI THERAPEUTICS ORD	597,711	$61.56M	6.2%	$53.32	—	COM	60468T105
—	DICERNA PHARMACEUTICALS ORD	3,316,407	$52.23M	5.3%	$9.60	—	COM	253031108
IRWD	IRONWOOD PHARMA CL A ORD	4,671,408	$51.1M	5.2%	$11.82	-5.2%	COM	46333X108
—	MORPHIC HOLDING ORD	2,266,804	$44.93M	4.5%	$19.82	—	COM	61775R105
RARE	ULTRAGENYX PHARMACEUTICAL ORD	497,899	$31.62M	3.2%	$57.14	+11.4%	COM	90400D108
—	PREVAIL THERAPEUTICS ORD	2,392,556	$31.58M	3.2%	$13.20	—	COM	74140Y101
—	ATRECA CL A ORD	1,486,979	$28.02M	2.8%	$18.84	—	COM	04965G109
—	CHIASMA ORD	3,043,827	$22.74M	2.3%	$5.00	—	COM	16706W102
—	HARPOON THERAPEUTICS ORD	1,348,423	$17.53M	1.8%	$9.47	—	COM	41358P106
GOSS	GOSSAMER BIO INC ORD	772,096	$17.13M	1.7%	$20.85	-8.3%	COM	38341P102
—	ARQULE ORD	1,300,000	$14.31M	1.4%	$11.01	—	COM	04269E107
—	FIBROGEN ORD	277,500	$12.54M	1.3%	$44.16	—	Call	31572Q808
—	EIGER BIOPHARMACEUTICAL ORD	1,136,043	$12.04M	1.2%	$11.49	—	COM	28249U105
RCUS	ARCUS BIOSCIENCES ORD	1,488,205	$11.79M	1.2%	$14.43	-30.6%	COM	03969F109
—	UNITY BIOTECHNOLOGY ORD	1,044,500	$9.923M	1.0%	$14.33	—	COM	91381U101
—	CYCLERION THERAPEUTICS ORD	776,206	$8.888M	0.9%	$11.45	—	COM	23255M105
PRTA	PROTHENA ORD	723,300	$7.645M	0.8%	$11.89	-13.6%	COM	G72800108
—	RUBIUS THERAPEUTICS ORD	463,152	$7.285M	0.7%	$23.51	—	COM	78116T103
—	ASSEMBLY BIOSCIENCES ORD	498,300	$6.723M	0.7%	$8.38	—	Call	045396108
—	SURFACE ONCOLOGY ORD	2,312,688	$6.522M	0.7%	$10.23	—	COM	86877M209
—	MERSANA THERAPEUTICS ORD	1,392,231	$5.639M	0.6%	$5.26	—	COM	59045L106
—	CURIS ORD	2,982,208	$5.547M	0.6%	$0.69	—	COM	231269200
—	AQUINOX PHARMACEUTICALS ORD	2,265,880	$5.347M	0.5%	$2.79	—	COM	03842B101
RYTM	RHYTHM PHARMACEUTICALS ORD	223,167	$4.91M	0.5%	$27.64	-8.6%	COM	76243J105
—	SOLID BIOSCIENCES ORD	827,000	$4.755M	0.5%	$5.75	—	COM	83422E105
—	NGM BIOPHARMACEUTICALS ORD	316,900	$4.639M	0.5%	$14.64	—	COM	62921N105
—	KEZAR LIFE SCIENCES ORD	583,293	$4.497M	0.5%	$17.35	—	COM	49372L100
—	ADURO BIOTECH ORD	1,761,421	$2.713M	0.3%	$3.98	—	COM	00739L101
VCEL	VERICEL ORD	131,001	$2.475M	0.3%	$18.29	-6.8%	COM	92346J108
—	SYROS PHARMACEUTICALS ORD	248,480	$2.301M	0.2%	$9.26	—	COM	87184Q107
—	REGULUS THERAPEUTICS	1,111,110	$1.389M	0.1%	$1.25	—	COM	75915K200
—	GAMIDA CELL ORD	52,120	$265K	0.0%	$5.08	—	COM	M47364100
—	TCR2 THERAPEUTICS ORD	16,114	$231K	0.0%	$14.34	—	COM	87808K106