Rosalind Advisors, Inc. Hedge Fund

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
PCVX	VAXCYTE INC	290,000	$16,852	6.8%	$52.77	0.0%	COM	92243G108
VOR	VOR BIOPHARMA INC	700,000	$12,488	5.0%	$13.98	0.0%	COM NEW	929033207
CLDX	CELLDEX THERAPEUTICS INC	330,000	$10,468	4.2%	$25.41	0.0%	COM NEW	15117B202
BCRX	BIOCRYST PHARMACEUTICALS INC	923,057	$8,788	3.5%	$7.00	0.0%	COM	09058V103
AVIR	ATEA PHARMACEUTICALS INC	1,171,855	$6,305	2.5%	$3.98	0.0%	COM	04683R106
OVID	OVID THERAPEUTICS INC	1,107,994	$2,460	1.0%	$1.60	0.0%	COM	690469101
DFTX	DEFINIUM THERAPEUTICS INC	125,000	$2,363	0.9%	$16.29	0.0%	COM SHS	24477V105
LPCN	LIPOCINE INC	221,616	$1,771	0.7%	$9.20	0.0%	COM NEW	53630X203
AVTX	AVALO THERAPEUTICS INC	75,000	$1,120	0.4%	$15.50	0.0%	COM NEW	05338F306
ANNX	ANNEXON INC	200,000	$1,108	0.4%	$5.75	0.0%	COM	03589W102
AQST	AQUESTIVE THERAPEUTICS INC	250,000	$1,038	0.4%	$4.02	0.0%	COM	03843E104
—	VIRIDIAN THERAPEUTICS INC	263,600	$53	0.0%	—	—	PUT	92790C954

Increased Positions (8)

XFOR X4 PHARMACEUTICALS INC 5.3%

Value ($000) $13,277 (+27.4%) Shares 3,214,766 (+23.4%) Est. Cost $3.13 Unrealized +16.3%

— REPLIMUNE GROUP INC 1.1%

Value ($000) $2,747 (+23691.5%) Shares 1,275,600 (+452.4%) Est. Cost — Unrealized —

VSTM VERASTEM INC 4.6%

Value ($000) $11,334 (-17.9%) Shares 2,138,475 (+19.6%) Est. Cost $5.55 Unrealized +16.6%

FENC FENNEC PHARMACEUTICALS INC 7.2%

Value ($000) $17,885 (-11.1%) Shares 2,908,201 (+11.3%) Est. Cost $6.41 Unrealized +24.1%

XERS XERIS BIOPHARMA HOLDINGS INC 7.5%

Value ($000) $18,744 (+13.1%) Shares 3,231,700 (+53.0%) Est. Cost $4.30 Unrealized +67.6%

EYPT EYEPOINT PHARMACEUTICALS INC 5.4%

Value ($000) $13,364 (+6.0%) Shares 1,036,737 (+50.3%) Est. Cost $12.85 Unrealized +18.4%

BFRI BIOFRONTERA INC 0.4%

Value ($000) $942 (+44.8%) Shares 1,163,962 (+2.0%) Est. Cost $1.02 Unrealized -15.1%

— UNIQURE NV 0.0%

Value ($000) $0 (-100.0%) Shares 295,800 (+195.8%) Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
XFOR	X4 PHARMACEUTICALS INC	3,214,766 (+23.4%)	$13,277 (+27.4%)	5.3%	$3.13	+16.3%	COM NEW	98420X202
—	REPLIMUNE GROUP INC	1,275,600 (+452.4%)	$2,747 (+23691.5%)	1.1%	—	—	CALL	76029N906
VSTM	VERASTEM INC	2,138,475 (+19.6%)	$11,334 (-17.9%)	4.6%	$5.55	+16.6%	COM NEW	92337C203
FENC	FENNEC PHARMACEUTICALS INC	2,908,201 (+11.3%)	$17,885 (-11.1%)	7.2%	$6.41	+24.1%	COM	31447P100
XERS	XERIS BIOPHARMA HOLDINGS INC	3,231,700 (+53.0%)	$18,744 (+13.1%)	7.5%	$4.30	+67.6%	COM	98422E103
EYPT	EYEPOINT PHARMACEUTICALS INC	1,036,737 (+50.3%)	$13,364 (+6.0%)	5.4%	$12.85	+18.4%	COM NEW	30233G209
BFRI	BIOFRONTERA INC	1,163,962 (+2.0%)	$942 (+44.8%)	0.4%	$1.02	-15.1%	COM NEW	09077D209
—	UNIQURE NV	295,800 (+195.8%)	$0 (-100.0%)	0.0%	—	—	CALL	N90064901

Exited Positions (16)

REPL REPLIMUNE GROUP INC 5.5%

Value ($000) $13,710 Shares 1,410,497 Est. Cost $8.50 Unrealized -8.2%

ATYR ASTRIA THERAPEUTICS INC 5.5%

Value ($000) $13,602 Shares 1,039,080 Est. Cost $4.53 Unrealized -81.7%

CYTK CYTOKINETICS INC 5.0%

Value ($000) $12,393 Shares 195,045 Est. Cost $34.78 Unrealized +85.3%

— MIND MEDICINE MINDMED INC 4.0%

Value ($000) $10,043 Shares 750,000 Est. Cost $8.46 Unrealized —

OCUL Ocular Therapeutix, Inc 2.0%

Value ($000) $4,856 Shares 400,000 Est. Cost $7.23 Unrealized +35.9%

AVBP ARRIVENT BIOPHARMA INC 1.7%

Value ($000) $4,343 Shares 215,871 Est. Cost $20.82 Unrealized +6.0%

— ANAVEX LIFE SCIENCES CORP 0.8%

Value ($000) $1,881 Shares 1,168,600 Est. Cost — Unrealized —

— SPDR SERIES TRUST 0.5%

Value ($000) $1,348 Shares 1,937,600 Est. Cost — Unrealized —

TRVI TREVI THERAPEUTICS INC 0.5%

Value ($000) $1,252 Shares 100,000 Est. Cost $2.31 Unrealized +373.9%

— ISHARES TR 0.4%

Value ($000) $1,112 Shares 200,000 Est. Cost — Unrealized —

GUTS FRACTYL HEALTH INC 0.3%

Value ($000) $849 Shares 385,731 Est. Cost $1.30 Unrealized -7.8%

— VERASTEM INC 0.1%

Value ($000) $160 Shares 268,600 Est. Cost — Unrealized —

— VIKING THERAPEUTICS INC 0.0%

Value ($000) $2 Shares 100,000 Est. Cost — Unrealized —

— REZOLUTE INC 0.0%

Value ($000) $0 Shares 263,100 Est. Cost — Unrealized —

— REPLIMUNE GROUP INC 0.0%

Value ($000) $0 Shares 264,700 Est. Cost — Unrealized —

— VISTAGEN THERAPEUTICS INC 0.0%

Value ($000) $0 Shares 493,400 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
REPL	REPLIMUNE GROUP INC	1,410,497	$13,710	5.5%	$8.50	-8.2%	—	76029N106
ATYR	ASTRIA THERAPEUTICS INC	1,039,080	$13,602	5.5%	$4.53	-81.7%	—	002120202
CYTK	CYTOKINETICS INC	195,045	$12,393	5.0%	$34.78	+85.3%	—	23282W605
—	MIND MEDICINE MINDMED INC	750,000	$10,043	4.0%	$8.46	—	—	60255C885
OCUL	Ocular Therapeutix, Inc	400,000	$4,856	2.0%	$7.23	+35.9%	—	67576A100
AVBP	ARRIVENT BIOPHARMA INC	215,871	$4,343	1.7%	$20.82	+6.0%	—	04272N102
—	ANAVEX LIFE SCIENCES CORP	1,168,600	$1,881	0.8%	—	—	PUT	032797950
—	SPDR SERIES TRUST	1,937,600	$1,348	0.5%	—	—	PUT	78464A950
TRVI	TREVI THERAPEUTICS INC	100,000	$1,252	0.5%	$2.31	+373.9%	—	89532M101
—	ISHARES TR	200,000	$1,112	0.4%	—	—	PUT	464287955
GUTS	FRACTYL HEALTH INC	385,731	$849	0.3%	$1.30	-7.8%	—	35168W103
—	VERASTEM INC	268,600	$160	0.1%	—	—	CALL	92337C903
—	VIKING THERAPEUTICS INC	100,000	$2	0.0%	—	—	CALL	92686J906
—	REZOLUTE INC	263,100	$0	0.0%	—	—	CALL	76200L909
—	REPLIMUNE GROUP INC	264,700	$0	0.0%	—	—	PUT	76029N956
—	VISTAGEN THERAPEUTICS INC	493,400	$0	0.0%	—	—	CALL	92840H900

Decreased Positions (10)

VRDN VIRIDIAN THERAPEUTICS INC 2.0%

Value ($000) $4,898 (-65.0%) Shares 250,401 (-44.4%) Est. Cost $16.51 Unrealized +86.8%

HELP CYBIN INC 3.0%

Value ($000) $7,353 (-45.8%) Shares 1,531,814 (-7.6%) Est. Cost $8.53 Unrealized -16.7%

CGON CG ONCOLOGY INC 2.7%

Value ($000) $6,768 (-45.7%) Shares 100,000 (-66.7%) Est. Cost $25.87 Unrealized +102.6%

PROF PROFOUND MEDICAL CORP 2.2%

Value ($000) $5,366 (-36.2%) Shares 828,118 (-22.5%) Est. Cost $8.06 Unrealized -7.8%

SVRA SAVARA INC 7.0%

Value ($000) $17,492 (-14.8%) Shares 3,203,721 (-5.9%) Est. Cost $3.31 Unrealized +72.1%

— INVESCO QQQ TR 0.4%

Value ($000) $1,053 (-65.2%) Shares 250,000 (-44.4%) Est. Cost — Unrealized —

TLPH TALPHERA INC 1.0%

Value ($000) $2,505 (-38.6%) Shares 3,353,916 (-6.3%) Est. Cost $0.60 Unrealized +59.3%

— SPDR S&P 500 ETF TR 0.4%

Value ($000) $959 (-49.2%) Shares 125,000 (-75.5%) Est. Cost — Unrealized —

PYPD POLYPID LTD 1.1%

Value ($000) $2,619 (-13.4%) Shares 597,926 (-14.2%) Est. Cost $4.49 Unrealized +0.6%

OKUR ONKURE THERAPEUTICS INC 0.7%

Value ($000) $1,837 (-13.3%) Shares 443,763 (-39.3%) Est. Cost $2.99 Unrealized -8.8%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
VRDN	VIRIDIAN THERAPEUTICS INC	250,401 (-44.4%)	$4,898 (-65.0%)	2.0%	$16.51	+86.8%	COM	92790C104
HELP	CYBIN INC	1,531,814 (-7.6%)	$7,353 (-45.8%)	3.0%	$8.53	-16.7%	COM NEW	23256X407
CGON	CG ONCOLOGY INC	100,000 (-66.7%)	$6,768 (-45.7%)	2.7%	$25.87	+102.6%	COM	156944100
PROF	PROFOUND MEDICAL CORP	828,118 (-22.5%)	$5,366 (-36.2%)	2.2%	$8.06	-7.8%	COM NEW	74319B502
SVRA	SAVARA INC	3,203,721 (-5.9%)	$17,492 (-14.8%)	7.0%	$3.31	+72.1%	COM	805111101
—	INVESCO QQQ TR	250,000 (-44.4%)	$1,053 (-65.2%)	0.4%	—	—	PUT	46090E953
TLPH	TALPHERA INC	3,353,916 (-6.3%)	$2,505 (-38.6%)	1.0%	$0.60	+59.3%	COM NEW	00444T209
—	SPDR S&P 500 ETF TR	125,000 (-75.5%)	$959 (-49.2%)	0.4%	—	—	PUT	78462F953
PYPD	POLYPID LTD	597,926 (-14.2%)	$2,619 (-13.4%)	1.1%	$4.49	+0.6%	COM	M8001Q126
OKUR	ONKURE THERAPEUTICS INC	443,763 (-39.3%)	$1,837 (-13.3%)	0.7%	$2.99	-8.8%	COM CL A	68277Q105

Unchanged Positions (8)

DCTH DELCATH SYSTEMS, INC. 12.3%

Value ($000) $30,628 Shares 3,300,389 Est. Cost $6.89 Unrealized +45.0%

MDWD MEDIWOUND LTD 4.8%

Value ($000) $12,067 Shares 749,054 Est. Cost $14.40 Unrealized +23.2%

RGNT REGENTIS BIOMATERIALS LTD 0.3%

Value ($000) $768 Shares 251,510 Est. Cost $6.86 Unrealized -16.3%

MYO MYOMO INC 1.0%

Value ($000) $2,599 Shares 3,847,272 Est. Cost $3.08 Unrealized -71.6%

NRXS NEURAXIS INC 0.7%

Value ($000) $1,694 Shares 286,138 Est. Cost $2.99 Unrealized +58.6%

NSPR INSPIREMD INC 2.6%

Value ($000) $6,366 Shares 3,905,743 Est. Cost $2.46 Unrealized -30.6%

— ARRIVENT BIOPHARMA INC 0.0%

Value ($000) $0 Shares 108,900 Est. Cost — Unrealized —

KURA KURA ONCOLOGY INC 0.3%

Value ($000) $813 Shares 100,000 Est. Cost $7.79 Unrealized +10.5%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
DCTH	DELCATH SYSTEMS, INC.	3,300,389	$30,628	12.3%	$6.89	+45.0%	COM NEW	24661P807
MDWD	MEDIWOUND LTD	749,054	$12,067	4.8%	$14.40	+23.2%	SHS NEW	M68830112
RGNT	REGENTIS BIOMATERIALS LTD	251,510	$768	0.3%	$6.86	-16.3%	ORDINARY SHARES	M8211G108
MYO	MYOMO INC	3,847,272	$2,599	1.0%	$3.08	-71.6%	COM NEW	62857J201
NRXS	NEURAXIS INC	286,138	$1,694	0.7%	$2.99	+58.6%	COM	64134X201
NSPR	INSPIREMD INC	3,905,743	$6,366	2.6%	$2.46	-30.6%	COM	45779A846
—	ARRIVENT BIOPHARMA INC	108,900	$0	0.0%	—	—	CALL	04272N902
KURA	KURA ONCOLOGY INC	100,000	$813	0.3%	$7.79	+10.5%	COM	50127T109