Octagon Capital Advisors LP Quant / Systematic

Location: New York, NY

CIK: 0001839435 · Show all filings

Period: Q3 2025 (← Previous) (Next →)

Filing Date: Nov 14, 2025

Total Value: $660M (100.0% shares, 0.0% debt)

Holdings (27)

ABVX ABIVAX SA 17.1%

Value $112M Shares 1,325,000 Est. Cost $9.73 Unrealized —

DNTH DIANTHUS THERAPEUTICS INC 14.4%

Value $95.1M Shares 2,416,667 Est. Cost $20.69 Unrealized +23.5%

GOSS GOSSAMER BIO INC 6.8%

Value $44.84M Shares 17,050,000 Est. Cost $1.89 Unrealized +16.4%

COGT COGENT BIOSCIENCES INC 6.3%

Value $41.27M Shares 2,874,111 Est. Cost $9.93 Unrealized +19.3%

AVBP ARRIVENT BIOPHARMA INC 5.5%

Value $36.37M Shares 1,971,054 Est. Cost $20.71 Unrealized -5.1%

OCUL OCULAR THERAPEUTIX INC 4.6%

Value $30.67M Shares 2,624,000 Est. Cost $7.47 Unrealized +60.2%

TSHA TAYSHA GENE THERAPIES INC 4.5%

Value $29.65M Shares 9,067,500 Est. Cost $2.19 Unrealized +29.5%

— MERUS N V 4.4%

Value $29M Shares 308,000 Est. Cost $44.25 Unrealized —

TRVI TREVI THERAPEUTICS INC 3.9%

Value $25.76M Shares 2,815,000 Est. Cost $4.91 Unrealized +52.8%

— MIND MEDICINE MINDMED INC 3.8%

Value $25.11M Shares 2,130,000 Est. Cost $8.34 Unrealized —

APLS APELLIS PHARMACEUTICALS INC 3.1%

Value $20.45M Shares 903,500 Est. Cost $47.09 Unrealized -50.5%

KYMR KYMERA THERAPEUTICS INC 3.1%

Value $20.38M Shares 360,000 Est. Cost $37.22 Unrealized +21.2%

CNTA CENTESSA PHARMACEUTICALS PLC 3.1%

Value $20.13M Shares 830,000 Est. Cost $7.34 Unrealized —

— CIDARA THERAPEUTICS INC 2.9%

Value $19.15M Shares 200,000 Est. Cost $95.76 Unrealized —

PHVS PHARVARIS N V 2.7%

Value $18.03M Shares 722,595 Est. Cost $18.98 Unrealized +16.9%

KALV KALVISTA PHARMACEUTICALS INC 2.4%

Value $15.51M Shares 1,273,333 Est. Cost $10.36 Unrealized +33.4%

CRBP CORBUS PHARMACEUTICALS HLDGS 2.1%

Value $14.1M Shares 1,115,000 Est. Cost $40.87 Unrealized -76.7%

BBOT BRIDGEBIO ONCOLOGY THERAPEUT 1.8%

Value $12.08M Shares 1,043,110 Est. Cost $11.58 Unrealized —

DBVT DBV TECHNOLOGIES S A 1.5%

Value $10.18M Shares 1,018,021 Est. Cost $9.15 Unrealized —

NUVB NUVATION BIO INC 1.5%

Value $9.743M Shares 2,633,334 Est. Cost $2.99 Unrealized -9.0%

— CIDARA THERAPEUTICS INC 1.5%

Value $9.576M Shares 100,000 Est. Cost $95.76 Unrealized —

MAZE MAZE THERAPEUTICS INC 0.7%

Value $4.607M Shares 177,667 Est. Cost $12.04 Unrealized +40.2%

NGNE NEUROGENE INC 0.7%

Value $4.367M Shares 252,000 Est. Cost $37.29 Unrealized -46.1%

UNCY UNICYCIVE THERAPEUTICS INC 0.7%

Value $4.36M Shares 1,000,000 Est. Cost $6.18 Unrealized -29.5%

PEPG PEPGEN INC 0.5%

Value $3.234M Shares 700,000 Est. Cost $1.61 Unrealized 0.0%

GPCR STRUCTURE THERAPEUTICS INC 0.5%

Value $3.22M Shares 115,000 Est. Cost $28.00 Unrealized —

— NUVATION BIO INC 0.1%

Value $385K Shares 104,112 Est. Cost $1.77 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ABVX	ABIVAX SA	1,325,000	$112M	17.1%	$9.73	—	SPONSORED ADS	00370M103
DNTH	DIANTHUS THERAPEUTICS INC	2,416,667	$95.1M	14.4%	$20.69	+23.5%	COM	252828108
GOSS	GOSSAMER BIO INC	17,050,000	$44.84M	6.8%	$1.89	+16.4%	COM	38341P102
COGT	COGENT BIOSCIENCES INC	2,874,111	$41.27M	6.3%	$9.93	+19.3%	COM	19240Q201
AVBP	ARRIVENT BIOPHARMA INC	1,971,054	$36.37M	5.5%	$20.71	-5.1%	COM	04272N102
OCUL	OCULAR THERAPEUTIX INC	2,624,000	$30.67M	4.6%	$7.47	+60.2%	COM	67576A100
TSHA	TAYSHA GENE THERAPIES INC	9,067,500	$29.65M	4.5%	$2.19	+29.5%	COM SHS	877619106
—	MERUS N V	308,000	$29M	4.4%	$44.25	—	COM	N5749R100
TRVI	TREVI THERAPEUTICS INC	2,815,000	$25.76M	3.9%	$4.91	+52.8%	COM	89532M101
—	MIND MEDICINE MINDMED INC	2,130,000	$25.11M	3.8%	$8.34	—	COM NEW	60255C885
APLS	APELLIS PHARMACEUTICALS INC	903,500	$20.45M	3.1%	$47.09	-50.5%	COM	03753U106
KYMR	KYMERA THERAPEUTICS INC	360,000	$20.38M	3.1%	$37.22	+21.2%	COM	501575104
CNTA	CENTESSA PHARMACEUTICALS PLC	830,000	$20.13M	3.1%	$7.34	—	SPONSORED ADS	152309100
—	CIDARA THERAPEUTICS INC	200,000	$19.15M	2.9%	$95.76	—	Call	171757206
PHVS	PHARVARIS N V	722,595	$18.03M	2.7%	$18.98	+16.9%	COM	N69605108
KALV	KALVISTA PHARMACEUTICALS INC	1,273,333	$15.51M	2.4%	$10.36	+33.4%	COM	483497103
CRBP	CORBUS PHARMACEUTICALS HLDGS	1,115,000	$14.1M	2.1%	$40.87	-76.7%	COM NEW	21833P301
BBOT	BRIDGEBIO ONCOLOGY THERAPEUT	1,043,110	$12.08M	1.8%	$11.58	—	COM NEW	107924102
DBVT	DBV TECHNOLOGIES S A	1,018,021	$10.18M	1.5%	$9.15	—	SPONSORED ADS	23306J309
NUVB	NUVATION BIO INC	2,633,334	$9.743M	1.5%	$2.99	-9.0%	COM CL A	67080N101
—	CIDARA THERAPEUTICS INC	100,000	$9.576M	1.5%	$95.76	—	COM NEW	171757206
MAZE	MAZE THERAPEUTICS INC	177,667	$4.607M	0.7%	$12.04	+40.2%	COM	578784100
NGNE	NEUROGENE INC	252,000	$4.367M	0.7%	$37.29	-46.1%	COM	64135M105
UNCY	UNICYCIVE THERAPEUTICS INC	1,000,000	$4.36M	0.7%	$6.18	-29.5%	COM NEW	90466Y202
PEPG	PEPGEN INC	700,000	$3.234M	0.5%	$1.61	0.0%	COM	713317105
GPCR	STRUCTURE THERAPEUTICS INC	115,000	$3.22M	0.5%	$28.00	—	SPONSORED ADS	86366E106
—	NUVATION BIO INC	104,112	$385K	0.1%	$1.77	—	*W EXP 02/10/202	67080N119