Paradigm Biocapital Advisors LP Quant / Systematic

CIK: 0001855655 · Show all filings

Period: Q1 2023 (← Previous) (Next →)

Filing Date: May 15, 2023

Total Value ($000): $1,055,175 (100.0% shares, 0.0% debt)

Holdings (25)

BIIB BIOGEN INC 9.2%

Value ($000) $97,197 Shares 349,593 Est. Cost $249.64 Unrealized +10.8%

INCY INCYTE CORP 8.6%

Value ($000) $91,184 Shares 1,261,711 Est. Cost $75.77 Unrealized +3.3%

LEGN LEGEND BIOTECH CORP 6.9%

Value ($000) $72,828 Shares 1,510,324 Est. Cost $44.56 Unrealized —

ARGX ARGENX SE 6.4%

Value ($000) $67,501 Shares 181,172 Est. Cost $375.49 Unrealized —

— SEAGEN INC 5.4%

Value ($000) $57,090 Shares 281,969 Est. Cost $128.51 Unrealized —

IMCR IMMUNOCORE HLDGS PLC 5.3%

Value ($000) $55,682 Shares 1,126,256 Est. Cost $39.83 Unrealized —

ACLX ARCELLX INC 5.1%

Value ($000) $54,157 Shares 1,757,779 Est. Cost $26.62 Unrealized +13.9%

VRDN VIRIDIAN THERAPEUTICS INC 5.0%

Value ($000) $53,060 Shares 2,085,698 Est. Cost $20.81 Unrealized +54.1%

— MIRATI THERAPEUTICS INC 4.9%

Value ($000) $51,932 Shares 1,396,779 Est. Cost $63.82 Unrealized —

SNDX SYNDAX PHARMACEUTICALS INC 4.6%

Value ($000) $48,038 Shares 2,274,512 Est. Cost $21.27 Unrealized +16.9%

UTHR UNITED THERAPEUTICS CORP DEL 4.5%

Value ($000) $47,455 Shares 211,892 Est. Cost $214.15 Unrealized +15.1%

KROS KEROS THERAPEUTICS INC 3.8%

Value ($000) $39,743 Shares 930,752 Est. Cost $50.51 Unrealized 0.0%

ONC BEIGENE LTD 3.8%

Value ($000) $39,660 Shares 184,012 Est. Cost $215.53 Unrealized —

— CEREVEL THERAPEUTICS HLDNG I 3.7%

Value ($000) $38,907 Shares 1,595,199 Est. Cost $24.39 Unrealized —

BCYC BICYCLE THERAPEUTICS PLC 3.7%

Value ($000) $38,643 Shares 1,816,781 Est. Cost $19.14 Unrealized —

ASND ASCENDIS PHARMA A/S 3.6%

Value ($000) $37,620 Shares 350,866 Est. Cost $117.62 Unrealized —

— VOR BIOPHARMA INC 3.3%

Value ($000) $34,852 Shares 6,477,999 Est. Cost $6.84 Unrealized —

ZLAB ZAI LAB LTD 2.5%

Value ($000) $25,961 Shares 780,558 Est. Cost $31.57 Unrealized —

XENE XENON PHARMACEUTICALS INC 2.2%

Value ($000) $23,302 Shares 651,068 Est. Cost $36.94 Unrealized 0.0%

— VERONA PHARMA PLC 1.8%

Value ($000) $19,324 Shares 962,361 Est. Cost $20.08 Unrealized —

CRNX CRINETICS PHARMACEUTICALS IN 1.7%

Value ($000) $18,209 Shares 1,133,782 Est. Cost $19.08 Unrealized -3.0%

— ALPINE IMMUNE SCIENCES INC 1.7%

Value ($000) $17,892 Shares 2,317,634 Est. Cost $7.74 Unrealized —

— THESEUS PHARMACEUTICALS INC 1.3%

Value ($000) $13,367 Shares 1,505,327 Est. Cost $8.88 Unrealized —

OLMA OLEMA PHARMACEUTICALS INC 0.8%

Value ($000) $8,267 Shares 2,382,377 Est. Cost $4.08 Unrealized 0.0%

— POSEIDA THERAPEUTICS INC 0.3%

Value ($000) $3,303 Shares 1,072,410 Est. Cost $3.79 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
BIIB	BIOGEN INC	349,593	$97,197	9.2%	$249.64	+10.8%	COM	09062X103
INCY	INCYTE CORP	1,261,711	$91,184	8.6%	$75.77	+3.3%	COM	45337C102
LEGN	LEGEND BIOTECH CORP	1,510,324	$72,828	6.9%	$44.56	—	SPONSORED ADS	52490G102
ARGX	ARGENX SE	181,172	$67,501	6.4%	$375.49	—	SPONSORED ADR	04016X101
—	SEAGEN INC	281,969	$57,090	5.4%	$128.51	—	COM	81181C104
IMCR	IMMUNOCORE HLDGS PLC	1,126,256	$55,682	5.3%	$39.83	—	ADS	45258D105
ACLX	ARCELLX INC	1,757,779	$54,157	5.1%	$26.62	+13.9%	COMMON STOCK	03940C100
VRDN	VIRIDIAN THERAPEUTICS INC	2,085,698	$53,060	5.0%	$20.81	+54.1%	COM	92790C104
—	MIRATI THERAPEUTICS INC	1,396,779	$51,932	4.9%	$63.82	—	COM	60468T105
SNDX	SYNDAX PHARMACEUTICALS INC	2,274,512	$48,038	4.6%	$21.27	+16.9%	COM	87164F105
UTHR	UNITED THERAPEUTICS CORP DEL	211,892	$47,455	4.5%	$214.15	+15.1%	COM	91307C102
KROS	KEROS THERAPEUTICS INC	930,752	$39,743	3.8%	$50.51	0.0%	COM	492327101
ONC	BEIGENE LTD	184,012	$39,660	3.8%	$215.53	—	SPONSORED ADR	07725L102
—	CEREVEL THERAPEUTICS HLDNG I	1,595,199	$38,907	3.7%	$24.39	—	COM	15678U128
BCYC	BICYCLE THERAPEUTICS PLC	1,816,781	$38,643	3.7%	$19.14	—	SPONSORED ADS	088786108
ASND	ASCENDIS PHARMA A/S	350,866	$37,620	3.6%	$117.62	—	SPONSORED ADR	04351P101
—	VOR BIOPHARMA INC	6,477,999	$34,852	3.3%	$6.84	—	COM	929033108
ZLAB	ZAI LAB LTD	780,558	$25,961	2.5%	$31.57	—	ADR	98887Q104
XENE	XENON PHARMACEUTICALS INC	651,068	$23,302	2.2%	$36.94	0.0%	COM	98420N105
—	VERONA PHARMA PLC	962,361	$19,324	1.8%	$20.08	—	SPONSORED ADS	925050106
CRNX	CRINETICS PHARMACEUTICALS IN	1,133,782	$18,209	1.7%	$19.08	-3.0%	COM	22663K107
—	ALPINE IMMUNE SCIENCES INC	2,317,634	$17,892	1.7%	$7.74	—	COM	02083G100
—	THESEUS PHARMACEUTICALS INC	1,505,327	$13,367	1.3%	$8.88	—	COM	88369M101
OLMA	OLEMA PHARMACEUTICALS INC	2,382,377	$8,267	0.8%	$4.08	0.0%	COM	68062P106
—	POSEIDA THERAPEUTICS INC	1,072,410	$3,303	0.3%	$3.79	—	COM	73730P108