Paradigm Biocapital Advisors LP Quant / Systematic

Location: New York, NY

CIK: 0001855655 · Show all filings

Period: Q2 2023 (← Previous) (Next →)

Filing Date: Aug 14, 2023

Total Value: $1.294B (100.0% shares, 0.0% debt)

Holdings (30)

LEGN LEGEND BIOTECH CORP 9.6%

Value $125M Shares 1,805,717 Est. Cost $48.56 Unrealized —

INCY INCYTE CORP 6.6%

Value $86.01M Shares 1,381,711 Est. Cost $74.99 Unrealized -10.9%

IMCR IMMUNOCORE HLDGS PLC 5.9%

Value $76.16M Shares 1,270,124 Est. Cost $42.11 Unrealized —

ACLX ARCELLX INC 5.7%

Value $74.21M Shares 2,347,000 Est. Cost $29.54 Unrealized +29.4%

— KARUNA THERAPEUTICS INC 4.8%

Value $61.5M Shares 283,605 Est. Cost $216.85 Unrealized —

— CEREVEL THERAPEUTICS HLDNG I 4.6%

Value $59.41M Shares 1,868,946 Est. Cost $25.47 Unrealized —

ARGX ARGENX SE 4.5%

Value $58.46M Shares 150,000 Est. Cost $375.49 Unrealized —

VRDN VIRIDIAN THERAPEUTICS INC 4.4%

Value $57.46M Shares 2,415,256 Est. Cost $21.47 Unrealized +19.5%

ARGX ARGENX SE 4.3%

Value $55.44M Shares 142,259 Est. Cost $375.49 Unrealized —

UTHR UNITED THERAPEUTICS CORP DEL 4.1%

Value $52.62M Shares 238,388 Est. Cost $214.96 Unrealized +3.0%

— MIRATI THERAPEUTICS INC 4.0%

Value $52.16M Shares 1,443,762 Est. Cost $62.92 Unrealized —

SNDX SYNDAX PHARMACEUTICALS INC 3.9%

Value $50.74M Shares 2,424,132 Est. Cost $21.25 Unrealized -2.0%

BCYC BICYCLE THERAPEUTICS PLC 3.9%

Value $50.67M Shares 1,985,430 Est. Cost $19.68 Unrealized —

NUVL NUVALENT INC 3.7%

Value $47.25M Shares 1,120,465 Est. Cost $37.81 Unrealized 0.0%

ONC BEIGENE LTD 3.0%

Value $38.53M Shares 216,093 Est. Cost $210.00 Unrealized —

XENE XENON PHARMACEUTICALS INC 2.9%

Value $38.09M Shares 989,327 Est. Cost $37.90 Unrealized +4.9%

OLMA OLEMA PHARMACEUTICALS INC 2.6%

Value $33.69M Shares 3,731,046 Est. Cost $4.79 Unrealized +26.1%

— AMBRX BIOPHARMA INC 2.1%

Value $27.17M Shares 1,650,499 Est. Cost $16.46 Unrealized —

CRNX CRINETICS PHARMACEUTICALS IN 1.9%

Value $25.14M Shares 1,395,002 Est. Cost $19.24 Unrealized +3.6%

— ALPINE IMMUNE SCIENCES INC 1.9%

Value $24.92M Shares 2,423,961 Est. Cost $7.85 Unrealized —

VIR VIR BIOTECHNOLOGY INC 1.9%

Value $24.88M Shares 1,014,239 Est. Cost $25.11 Unrealized 0.0%

ZLAB ZAI LAB LTD 1.9%

Value $23.99M Shares 865,297 Est. Cost $31.19 Unrealized —

IMTX IMMATICS N.V 1.8%

Value $22.9M Shares 1,984,813 Est. Cost $9.33 Unrealized 0.0%

AUTL AUTOLUS THERAPEUTICS PLC 1.7%

Value $21.94M Shares 9,217,150 Est. Cost $2.38 Unrealized —

— VOR BIOPHARMA INC 1.5%

Value $19.97M Shares 6,461,467 Est. Cost $6.84 Unrealized —

MDGL MADRIGAL PHARMACEUTICALS INC 1.5%

Value $19.64M Shares 85,000 Est. Cost $270.85 Unrealized 0.0%

— VERONA PHARMA PLC 1.5%

Value $18.9M Shares 893,861 Est. Cost $20.08 Unrealized —

MLTX MOONLAKE IMMUNOTHERAPEUTICS 1.5%

Value $18.85M Shares 369,615 Est. Cost $26.91 Unrealized 0.0%

— THESEUS PHARMACEUTICALS INC 1.4%

Value $18.2M Shares 1,950,327 Est. Cost $8.98 Unrealized —

KURA KURA ONCOLOGY INC 0.8%

Value $10.63M Shares 1,004,908 Est. Cost $11.83 Unrealized 0.0%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
LEGN	LEGEND BIOTECH CORP	1,805,717	$125M	9.6%	$48.56	—	SPONSORED ADS	52490G102
INCY	INCYTE CORP	1,381,711	$86.01M	6.6%	$74.99	-10.9%	COM	45337C102
IMCR	IMMUNOCORE HLDGS PLC	1,270,124	$76.16M	5.9%	$42.11	—	ADS	45258D105
ACLX	ARCELLX INC	2,347,000	$74.21M	5.7%	$29.54	+29.4%	COMMON STOCK	03940C100
—	KARUNA THERAPEUTICS INC	283,605	$61.5M	4.8%	$216.85	—	COM	48576A100
—	CEREVEL THERAPEUTICS HLDNG I	1,868,946	$59.41M	4.6%	$25.47	—	COM	15678U128
ARGX	ARGENX SE	150,000	$58.46M	4.5%	$375.49	—	Put	04016X101
VRDN	VIRIDIAN THERAPEUTICS INC	2,415,256	$57.46M	4.4%	$21.47	+19.5%	COM	92790C104
ARGX	ARGENX SE	142,259	$55.44M	4.3%	$375.49	—	SPONSORED ADR	04016X101
UTHR	UNITED THERAPEUTICS CORP DEL	238,388	$52.62M	4.1%	$214.96	+3.0%	COM	91307C102
—	MIRATI THERAPEUTICS INC	1,443,762	$52.16M	4.0%	$62.92	—	COM	60468T105
SNDX	SYNDAX PHARMACEUTICALS INC	2,424,132	$50.74M	3.9%	$21.25	-2.0%	COM	87164F105
BCYC	BICYCLE THERAPEUTICS PLC	1,985,430	$50.67M	3.9%	$19.68	—	SPONSORED ADS	088786108
NUVL	NUVALENT INC	1,120,465	$47.25M	3.7%	$37.81	0.0%	COM	670703107
ONC	BEIGENE LTD	216,093	$38.53M	3.0%	$210.00	—	SPONSORED ADR	07725L102
XENE	XENON PHARMACEUTICALS INC	989,327	$38.09M	2.9%	$37.90	+4.9%	COM	98420N105
OLMA	OLEMA PHARMACEUTICALS INC	3,731,046	$33.69M	2.6%	$4.79	+26.1%	COM	68062P106
—	AMBRX BIOPHARMA INC	1,650,499	$27.17M	2.1%	$16.46	—	SPONSORED ADS	02290A102
CRNX	CRINETICS PHARMACEUTICALS IN	1,395,002	$25.14M	1.9%	$19.24	+3.6%	COM	22663K107
—	ALPINE IMMUNE SCIENCES INC	2,423,961	$24.92M	1.9%	$7.85	—	COM	02083G100
VIR	VIR BIOTECHNOLOGY INC	1,014,239	$24.88M	1.9%	$25.11	0.0%	COM	92764N102
ZLAB	ZAI LAB LTD	865,297	$23.99M	1.9%	$31.19	—	ADR	98887Q104
IMTX	IMMATICS N.V	1,984,813	$22.9M	1.8%	$9.33	0.0%	SHS	N44445109
AUTL	AUTOLUS THERAPEUTICS PLC	9,217,150	$21.94M	1.7%	$2.38	—	SPON ADS	05280R100
—	VOR BIOPHARMA INC	6,461,467	$19.97M	1.5%	$6.84	—	COM	929033108
MDGL	MADRIGAL PHARMACEUTICALS INC	85,000	$19.64M	1.5%	$270.85	0.0%	COM	558868105
—	VERONA PHARMA PLC	893,861	$18.9M	1.5%	$20.08	—	SPONSORED ADS	925050106
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	369,615	$18.85M	1.5%	$26.91	0.0%	CLASS A ORD	61559X104
—	THESEUS PHARMACEUTICALS INC	1,950,327	$18.2M	1.4%	$8.98	—	COM	88369M101
KURA	KURA ONCOLOGY INC	1,004,908	$10.63M	0.8%	$11.83	0.0%	COM	50127T109