Paradigm Biocapital Advisors LP Quant / Systematic

Location: New York, NY

CIK: 0001855655 · Show all filings

Period: Q4 2022 (← Previous) (Next →)

Filing Date: Feb 14, 2023

Total Value: $852M (100.0% shares, 0.0% debt)

Holdings (23)

INCY INCYTE CORP 8.0%

Value $68.5M Shares 852,830 Est. Cost $74.59 Unrealized +2.6%

BIIB BIOGEN INC 7.8%

Value $66.12M Shares 238,772 Est. Cost $237.08 Unrealized +19.1%

— MIRATI THERAPEUTICS INC 6.7%

Value $57.45M Shares 1,267,970 Est. Cost $66.52 Unrealized —

— HORIZON THERAPEUTICS PUB L 6.4%

Value $54.35M Shares 477,585 Est. Cost $75.60 Unrealized —

LEGN LEGEND BIOTECH CORP 6.2%

Value $52.66M Shares 1,054,870 Est. Cost $42.97 Unrealized —

VRDN VIRIDIAN THERAPEUTICS INC 6.0%

Value $51.15M Shares 1,751,167 Est. Cost $18.66 Unrealized +23.5%

SNDX SYNDAX PHARMACEUTICALS INC 5.8%

Value $49.74M Shares 1,954,512 Est. Cost $20.69 Unrealized +12.8%

IMCR IMMUNOCORE HLDGS PLC 5.7%

Value $48.96M Shares 857,925 Est. Cost $36.82 Unrealized —

ASND ASCENDIS PHARMA A/S 5.1%

Value $43.09M Shares 352,808 Est. Cost $117.62 Unrealized —

— VOR BIOPHARMA INC 5.0%

Value $42.84M Shares 6,442,825 Est. Cost $6.84 Unrealized —

UTHR UNITED THERAPEUTICS CORP DEL 4.9%

Value $41.41M Shares 148,892 Est. Cost $200.45 Unrealized +25.9%

— SEAGEN INC 4.3%

Value $36.79M Shares 286,288 Est. Cost $128.51 Unrealized —

BCYC BICYCLE THERAPEUTICS PLC 4.3%

Value $36.51M Shares 1,233,280 Est. Cost $18.13 Unrealized —

ARGX ARGENX SE 4.0%

Value $33.93M Shares 89,556 Est. Cost $378.46 Unrealized —

— AKERO THERAPEUTICS INC 3.9%

Value $33.13M Shares 604,544 Est. Cost $34.05 Unrealized —

ACLX ARCELLX INC 3.2%

Value $27.33M Shares 882,101 Est. Cost $22.94 Unrealized 0.0%

— KARUNA THERAPEUTICS INC 2.4%

Value $20.87M Shares 106,210 Est. Cost $196.50 Unrealized —

ARVN ARVINAS INC 2.4%

Value $20.51M Shares 599,599 Est. Cost $57.23 Unrealized -26.5%

— ALPINE IMMUNE SCIENCES INC 2.0%

Value $17.03M Shares 2,317,634 Est. Cost $7.74 Unrealized —

CRNX CRINETICS PHARMACEUTICALS IN 1.9%

Value $16.29M Shares 890,105 Est. Cost $19.24 Unrealized -8.4%

ZLAB ZAI LAB LTD 1.9%

Value $15.82M Shares 515,274 Est. Cost $30.70 Unrealized —

— POSEIDA THERAPEUTICS INC 1.5%

Value $12.9M Shares 2,434,816 Est. Cost $3.79 Unrealized —

PRTA PROTHENA CORP PLC 0.5%

Value $4.519M Shares 75,000 Est. Cost $31.61 Unrealized +85.2%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
INCY	INCYTE CORP	852,830	$68.5M	8.0%	$74.59	+2.6%	COM	45337C102
BIIB	BIOGEN INC	238,772	$66.12M	7.8%	$237.08	+19.1%	COM	09062X103
—	MIRATI THERAPEUTICS INC	1,267,970	$57.45M	6.7%	$66.52	—	COM	60468T105
—	HORIZON THERAPEUTICS PUB L	477,585	$54.35M	6.4%	$75.60	—	SHS	G46188101
LEGN	LEGEND BIOTECH CORP	1,054,870	$52.66M	6.2%	$42.97	—	SPONSORED ADS	52490G102
VRDN	VIRIDIAN THERAPEUTICS INC	1,751,167	$51.15M	6.0%	$18.66	+23.5%	COM	92790C104
SNDX	SYNDAX PHARMACEUTICALS INC	1,954,512	$49.74M	5.8%	$20.69	+12.8%	COM	87164F105
IMCR	IMMUNOCORE HLDGS PLC	857,925	$48.96M	5.7%	$36.82	—	ADS	45258D105
ASND	ASCENDIS PHARMA A/S	352,808	$43.09M	5.1%	$117.62	—	SPONSORED ADR	04351P101
—	VOR BIOPHARMA INC	6,442,825	$42.84M	5.0%	$6.84	—	COM	929033108
UTHR	UNITED THERAPEUTICS CORP DEL	148,892	$41.41M	4.9%	$200.45	+25.9%	COM	91307C102
—	SEAGEN INC	286,288	$36.79M	4.3%	$128.51	—	COM	81181C104
BCYC	BICYCLE THERAPEUTICS PLC	1,233,280	$36.51M	4.3%	$18.13	—	SPONSORED ADS	088786108
ARGX	ARGENX SE	89,556	$33.93M	4.0%	$378.46	—	SPONSORED ADR	04016X101
—	AKERO THERAPEUTICS INC	604,544	$33.13M	3.9%	$34.05	—	COM	00973Y108
ACLX	ARCELLX INC	882,101	$27.33M	3.2%	$22.94	0.0%	COMMON STOCK	03940C100
—	KARUNA THERAPEUTICS INC	106,210	$20.87M	2.4%	$196.50	—	COM	48576A100
ARVN	ARVINAS INC	599,599	$20.51M	2.4%	$57.23	-26.5%	COM	04335A105
—	ALPINE IMMUNE SCIENCES INC	2,317,634	$17.03M	2.0%	$7.74	—	COM	02083G100
CRNX	CRINETICS PHARMACEUTICALS IN	890,105	$16.29M	1.9%	$19.24	-8.4%	COM	22663K107
ZLAB	ZAI LAB LTD	515,274	$15.82M	1.9%	$30.70	—	ADR	98887Q104
—	POSEIDA THERAPEUTICS INC	2,434,816	$12.9M	1.5%	$3.79	—	COM	73730P108
PRTA	PROTHENA CORP PLC	75,000	$4.519M	0.5%	$31.61	+85.2%	SHS	G72800108