Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
URGN	UROGEN PHARMA LTD	2,247,393	$40.41M	2.5%	—	—	COM	M96088105
LEGN	LEGEND BIOTECH CORP	1,576,295	$28.52M	1.8%	—	—	SPONSORED ADS	52490G102
TVTX	TRAVERE THERAPEUTICS INC	800,000	$23.77M	1.5%	—	—	CALL	89422G107
RVMD	REVOLUTION MEDICINES INC	207,500	$20.18M	1.2%	—	—	PUT	76155X100
SLNO	SOLENO THERAPEUTICS INC	560,000	$18.75M	1.2%	—	—	COM	834203309
TVTX	TRAVERE THERAPEUTICS INC	54,900	$1.631M	0.1%	—	—	PUT	89422G107
CADL	CANDEL THERAPEUTICS INC	200,000	$980K	0.1%	—	—	COM	137404109

Increased Positions (11)

CTMX CYTOMX THERAPEUTICS INC. 4.4%

Value $70.56M (+84.7%) Shares 15,013,093 (+67.4%) Est. Cost — Unrealized —

TVTX TRAVERE THERAPEUTICS INC 2.9%

Value $46.62M (+135.6%) Shares 1,569,018 (+203.0%) Est. Cost — Unrealized —

BEAM BEAM THERAPEUTICS INC 5.4%

Value $87.75M (+29.7%) Shares 3,682,185 (+50.9%) Est. Cost — Unrealized —

STRO SUTRO BIOPHARMA INC 1.3%

Value $21.74M (+291.7%) Shares 872,558 (+81.9%) Est. Cost — Unrealized —

EVMN EVOMMUNE INC 0.9%

Value $14.38M (+352.9%) Shares 625,496 (+237.2%) Est. Cost — Unrealized —

GERN GERON CORP 0.6%

Value $10.19M (+123.3%) Shares 6,836,318 (+97.8%) Est. Cost — Unrealized —

PRLD PRELUDE THERAPEUTICS INC 0.3%

Value $5.447M (+138.1%) Shares 1,592,551 (+101.9%) Est. Cost — Unrealized —

IMCR IMMUNOCORE HLDGS PLC 1.6%

Value $26.68M (-10.2%) Shares 884,937 (+3.3%) Est. Cost — Unrealized —

AMRN AMARIN CORP PLC 0.4%

Value $6.831M (+25.7%) Shares 472,382 (+21.3%) Est. Cost — Unrealized —

BNR BURNING ROCK BIOTECH LTD 1.2%

Value $19.79M (-1.3%) Shares 1,227,555 (+23.4%) Est. Cost — Unrealized —

VRDN VIRIDIAN THERAPEUTICS INC 2.8%

Value $45.8M (+0.1%) Shares 2,341,652 (+59.2%) Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
CTMX	CYTOMX THERAPEUTICS INC.	15,013,093 (+67.4%)	$70.56M (+84.7%)	4.4%	—	—	COM	23284F105
TVTX	TRAVERE THERAPEUTICS INC	1,569,018 (+203.0%)	$46.62M (+135.6%)	2.9%	—	—	COM	89422G107
BEAM	BEAM THERAPEUTICS INC	3,682,185 (+50.9%)	$87.75M (+29.7%)	5.4%	—	—	COM	07373V105
STRO	SUTRO BIOPHARMA INC	872,558 (+81.9%)	$21.74M (+291.7%)	1.3%	—	—	COM SHS	869367201
EVMN	EVOMMUNE INC	625,496 (+237.2%)	$14.38M (+352.9%)	0.9%	—	—	COM SHS	30054Y107
GERN	GERON CORP	6,836,318 (+97.8%)	$10.19M (+123.3%)	0.6%	—	—	COM	374163103
PRLD	PRELUDE THERAPEUTICS INC	1,592,551 (+101.9%)	$5.447M (+138.1%)	0.3%	—	—	COM	74065P101
IMCR	IMMUNOCORE HLDGS PLC	884,937 (+3.3%)	$26.68M (-10.2%)	1.6%	—	—	ADS	45258D105
AMRN	AMARIN CORP PLC	472,382 (+21.3%)	$6.831M (+25.7%)	0.4%	—	—	SPONSORED ADR	023111404
BNR	BURNING ROCK BIOTECH LTD	1,227,555 (+23.4%)	$19.79M (-1.3%)	1.2%	—	—	SPONSORED ADS	12233L206
VRDN	VIRIDIAN THERAPEUTICS INC	2,341,652 (+59.2%)	$45.8M (+0.1%)	2.8%	—	—	COM	92790C104

Exited Positions (5)

TYRA TYRA BIOSCIENCES INC 2.5%

Value $41.13M Shares 1,564,492 Est. Cost — Unrealized —

CGON CG ONCOLOGY INC 2.4%

Value $39.27M Shares 945,830 Est. Cost — Unrealized —

BEAM BEAM THERAPEUTICS INC 1.6%

Value $25.97M Shares 937,000 Est. Cost — Unrealized —

— DYNAVAX TECHNOLOGIES CORP 1.3%

Value $21.16M Shares 1,375,632 Est. Cost — Unrealized —

OMER OMEROS CORP 0.2%

Value $3.436M Shares 200,000 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
TYRA	TYRA BIOSCIENCES INC	1,564,492	$41.13M	2.5%	—	—	—	90240B106
CGON	CG ONCOLOGY INC	945,830	$39.27M	2.4%	—	—	—	156944100
BEAM	BEAM THERAPEUTICS INC	937,000	$25.97M	1.6%	—	—	CALL	07373V105
—	DYNAVAX TECHNOLOGIES CORP	1,375,632	$21.16M	1.3%	—	—	—	268158201
OMER	OMEROS CORP	200,000	$3.436M	0.2%	—	—	PUT	682143102

Decreased Positions (9)

COGT COGENT BIOSCIENCES INC 9.6%

Value $155M (-29.0%) Shares 4,037,331 (-34.5%) Est. Cost — Unrealized —

VERA VERA THERAPEUTICS INC 8.4%

Value $137M (-21.4%) Shares 3,398,224 (-1.0%) Est. Cost — Unrealized —

WVE WAVE LIFE SCIENCES LTD 0.4%

Value $6.998M (-81.0%) Shares 965,193 (-55.5%) Est. Cost — Unrealized —

CLDX CELLDEX THERAPEUTICS INC NEW 11.4%

Value $185M (+14.8%) Shares 5,840,567 (-1.7%) Est. Cost — Unrealized —

BCRX BIOCRYST PHARMACEUTICALS INC 3.3%

Value $54.08M (-26.0%) Shares 5,680,795 (-39.4%) Est. Cost — Unrealized —

NRIX NURIX THERAPEUTICS INC 1.1%

Value $18.52M (-50.5%) Shares 1,194,757 (-39.4%) Est. Cost — Unrealized —

APLS APELLIS PHARMACEUTICALS INC 2.0%

Value $33.19M (+45.4%) Shares 825,000 (-9.2%) Est. Cost — Unrealized —

ENGN ENGENE HOLDINGS INC 0.6%

Value $9.24M (-31.5%) Shares 1,356,843 (-9.1%) Est. Cost — Unrealized —

CLYM CLIMB BIO INC 0.4%

Value $6.873M (+67.1%) Shares 1,003,341 (-2.4%) Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
COGT	COGENT BIOSCIENCES INC	4,037,331 (-34.5%)	$155M (-29.0%)	9.6%	—	—	COM	19240Q201
VERA	VERA THERAPEUTICS INC	3,398,224 (-1.0%)	$137M (-21.4%)	8.4%	—	—	CL A	92337R101
WVE	WAVE LIFE SCIENCES LTD	965,193 (-55.5%)	$6.998M (-81.0%)	0.4%	—	—	SHS	Y95308105
CLDX	CELLDEX THERAPEUTICS INC NEW	5,840,567 (-1.7%)	$185M (+14.8%)	11.4%	—	—	COM NEW	15117B202
BCRX	BIOCRYST PHARMACEUTICALS INC	5,680,795 (-39.4%)	$54.08M (-26.0%)	3.3%	—	—	COM	09058V103
NRIX	NURIX THERAPEUTICS INC	1,194,757 (-39.4%)	$18.52M (-50.5%)	1.1%	—	—	COM	67080M103
APLS	APELLIS PHARMACEUTICALS INC	825,000 (-9.2%)	$33.19M (+45.4%)	2.0%	—	—	COM	03753U106
ENGN	ENGENE HOLDINGS INC	1,356,843 (-9.1%)	$9.24M (-31.5%)	0.6%	—	—	COM	29286M105
CLYM	CLIMB BIO INC	1,003,341 (-2.4%)	$6.873M (+67.1%)	0.4%	—	—	COM	28658R106

Unchanged Positions (12)

PCVX VAXCYTE INC 10.5%

Value $170M Shares 2,922,335 Est. Cost — Unrealized —

SNDX SYNDAX PHARMACEUTICALS INC 11.6%

Value $188M Shares 8,050,959 Est. Cost — Unrealized —

CGEM CULLINAN THERAPEUTICS INC 2.7%

Value $44.25M Shares 3,114,132 Est. Cost — Unrealized —

KALV KALVISTA PHARMACEUTICALS INC 2.3%

Value $36.66M Shares 1,820,954 Est. Cost — Unrealized —

RLAY RELAY THERAPEUTICS INC 0.9%

Value $14.17M Shares 1,424,259 Est. Cost — Unrealized —

BHVN BIOHAVEN LTD 0.4%

Value $5.946M Shares 702,884 Est. Cost — Unrealized —

MBX MBX BIOSCIENCES INC 1.7%

Value $27.9M Shares 934,799 Est. Cost — Unrealized —

ALEC ALECTOR INC 0.3%

Value $4.3M Shares 2,000,000 Est. Cost — Unrealized —

DSGN DESIGN THERAPEUTICS INC 0.5%

Value $8.348M Shares 784,606 Est. Cost — Unrealized —

CRBU CARIBOU BIOSCIENCES INC 0.3%

Value $4.756M Shares 2,503,302 Est. Cost — Unrealized —

PRQR PROQR THRAPEUTICS N V 0.2%

Value $2.537M Shares 1,566,317 Est. Cost — Unrealized —

PHVS PHARVARIS N V 1.1%

Value $18.09M Shares 640,395 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
PCVX	VAXCYTE INC	2,922,335	$170M	10.5%	—	—	COM	92243G108
SNDX	SYNDAX PHARMACEUTICALS INC	8,050,959	$188M	11.6%	—	—	COM	87164F105
CGEM	CULLINAN THERAPEUTICS INC	3,114,132	$44.25M	2.7%	—	—	COM	230031106
KALV	KALVISTA PHARMACEUTICALS INC	1,820,954	$36.66M	2.3%	—	—	COM	483497103
RLAY	RELAY THERAPEUTICS INC	1,424,259	$14.17M	0.9%	—	—	COM	75943R102
BHVN	BIOHAVEN LTD	702,884	$5.946M	0.4%	—	—	COM	G1110E107
MBX	MBX BIOSCIENCES INC	934,799	$27.9M	1.7%	—	—	COM	55287L101
ALEC	ALECTOR INC	2,000,000	$4.3M	0.3%	—	—	COM	014442107
DSGN	DESIGN THERAPEUTICS INC	784,606	$8.348M	0.5%	—	—	COM	25056L103
CRBU	CARIBOU BIOSCIENCES INC	2,503,302	$4.756M	0.3%	—	—	COM	142038108
PRQR	PROQR THRAPEUTICS N V	1,566,317	$2.537M	0.2%	—	—	SHS EURO	N71542109
PHVS	PHARVARIS N V	640,395	$18.09M	1.1%	—	—	COM	N69605108