ARCH Venture Management, LLC Diversified Active

CIK: 0001274403 · Show all filings

Period: Q4 2025 (← Previous)

Filing Date: Feb 17, 2026

Total Value ($000): $651,681 (100.0% shares, 0.0% debt)

Holdings (9)

New Positions (1)

TXG 10X GENOMICS INC. 1.8%

Value ($000) $12,029 Shares 737,539 Est. Cost $15.11 Unrealized 0.0%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
TXG	10X GENOMICS INC.	737,539	$12,029	1.8%	$15.11	0.0%	CL A COM	88025U109

Exited Positions (1)

CERO CERO THERAPEUTICS HOLDINGS INC. 0.0%

Value ($000) $114 Shares 22,389 Est. Cost $12.44 Unrealized -90.9%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
CERO	CERO THERAPEUTICS HOLDINGS INC.	22,389	$114	0.0%	$12.44	-90.9%	—	71902K402

Unchanged Positions (8)

MAZE MAZE THERAPEUTICS INC. 26.2%

Value ($000) $170,694 Shares 4,120,053 Est. Cost $12.04 Unrealized +185.5%

LYEL LYELL IMMUNOPHARMA INC. 13.0%

Value ($000) $84,924 Shares 2,759,072 Est. Cost $9.90 Unrealized +126.1%

ERAS ERASCA INC. 6.3%

Value ($000) $41,127 Shares 11,055,554 Est. Cost $17.12 Unrealized -83.6%

BEAM BEAM THERAPEUTICS INC. 19.3%

Value ($000) $125,852 Shares 4,540,132 Est. Cost $24.56 Unrealized +3.9%

VIR VIR BIOTECHNOLOGY INC. 12.0%

Value ($000) $77,887 Shares 12,916,663 Est. Cost $5.36 Unrealized +11.1%

GOSS GOSSAMER BIO INC. 3.8%

Value ($000) $24,973 Shares 8,055,916 Est. Cost $1.15 Unrealized +147.6%

RAPP RAPPORT THERAPEUTICS INC. 17.4%

Value ($000) $113,130 Shares 3,728,738 Est. Cost $23.15 Unrealized +19.5%

QTTB Q32 BIO INC. 0.2%

Value ($000) $1,064 Shares 320,482 Est. Cost $13.78 Unrealized -79.5%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
MAZE	MAZE THERAPEUTICS INC.	4,120,053	$170,694	26.2%	$12.04	+185.5%	COM	578784100
LYEL	LYELL IMMUNOPHARMA INC.	2,759,072	$84,924	13.0%	$9.90	+126.1%	COM NEW	55083R203
ERAS	ERASCA INC.	11,055,554	$41,127	6.3%	$17.12	-83.6%	COM	29479A108
BEAM	BEAM THERAPEUTICS INC.	4,540,132	$125,852	19.3%	$24.56	+3.9%	COM	07373V105
VIR	VIR BIOTECHNOLOGY INC.	12,916,663	$77,887	12.0%	$5.36	+11.1%	COM	92764N102
GOSS	GOSSAMER BIO INC.	8,055,916	$24,973	3.8%	$1.15	+147.6%	COM	38341P102
RAPP	RAPPORT THERAPEUTICS INC.	3,728,738	$113,130	17.4%	$23.15	+19.5%	COM	75383L102
QTTB	Q32 BIO INC.	320,482	$1,064	0.2%	$13.78	-79.5%	COM	746964105