Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
AGMB	AGOMAB THERAPEUTICS NV	1,550,000	$16.26M	1.2%	$10.49	—	SPONSORED ADS	00860C102
QGEN	QIAGEN NV	360,000	$14.41M	1.1%	$50.32	0.0%	ORD SHARES	N72482156
GRAL	GRAIL INC	230,000	$11.89M	0.9%	$94.37	0.0%	COM	384747101
PSNL	PERSONALIS INC	1,600,000	$10.19M	0.8%	$8.94	0.0%	COM	71535D106
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	450,000	$8.388M	0.6%	$16.05	0.0%	CLASS A ORD	61559X104
NTLA	INTELLIA THERAPEUTICS INC	355,000	$4.551M	0.3%	$12.40	0.0%	COM	45826J105
IRON	DISC MEDICINE INC	65,000	$4.156M	0.3%	$74.04	0.0%	COM	254604101
MRNA	MODERNA INC	75,000	$3.81M	0.3%	$42.94	0.0%	COM	60770K107
ANL	ADLAI NORTYE LTD	538,461	$3.726M	0.3%	$6.92	—	SPONSORED ADS	00704R109

Increased Positions (7)

RLAY RELAY THERAPEUTICS INC 10.9%

Value $143M (+30.4%) Shares 14,418,574 (+10.9%) Est. Cost $14.46 Unrealized -42.6%

TXG 10X GENOMICS INC 3.7%

Value $48.3M (+111.5%) Shares 2,275,000 (+62.5%) Est. Cost $16.93 Unrealized +17.2%

TSHA TAYSHA GENE THERAPIES INC 1.1%

Value $14.53M (+76.1%) Shares 3,250,000 (+116.7%) Est. Cost $4.80 Unrealized -0.9%

SRRK SCHOLAR ROCK HLDG CORP 1.3%

Value $17.21M (+50.2%) Shares 350,000 (+34.6%) Est. Cost $39.55 Unrealized +15.0%

HIMS HIMS & HERS HEALTH INC 1.1%

Value $14.53M (+16.2%) Shares 700,000 (+81.8%) Est. Cost $33.43 Unrealized -24.2%

NGNE NEUROGENE INC 2.2%

Value $28.63M (+7.3%) Shares 1,420,361 (+9.6%) Est. Cost $27.08 Unrealized -33.0%

GLUE MONTE ROSA THERAPEUTICS INC 0.2%

Value $3.06M (+126.9%) Shares 186,014 (+116.3%) Est. Cost $20.53 Unrealized +0.7%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
RLAY	RELAY THERAPEUTICS INC	14,418,574 (+10.9%)	$143M (+30.4%)	10.9%	$14.46	-42.6%	COM	75943R102
TXG	10X GENOMICS INC	2,275,000 (+62.5%)	$48.3M (+111.5%)	3.7%	$16.93	+17.2%	CL A COM	88025U109
TSHA	TAYSHA GENE THERAPIES INC	3,250,000 (+116.7%)	$14.53M (+76.1%)	1.1%	$4.80	-0.9%	COM SHS	877619106
SRRK	SCHOLAR ROCK HLDG CORP	350,000 (+34.6%)	$17.21M (+50.2%)	1.3%	$39.55	+15.0%	COM	80706P103
HIMS	HIMS & HERS HEALTH INC	700,000 (+81.8%)	$14.53M (+16.2%)	1.1%	$33.43	-24.2%	COM CL A	433000106
NGNE	NEUROGENE INC	1,420,361 (+9.6%)	$28.63M (+7.3%)	2.2%	$27.08	-33.0%	COM	64135M105
GLUE	MONTE ROSA THERAPEUTICS INC	186,014 (+116.3%)	$3.06M (+126.9%)	0.2%	$20.53	+0.7%	COM	61225M102

Exited Positions (7)

RNAM AVIDITY BIOSCIENCES INC 5.5%

Value $72.13M Shares 1,000,000 Est. Cost $14.11 Unrealized +415.0%

SPRY ARS PHARMACEUTICALS INC 1.4%

Value $18.64M Shares 1,600,000 Est. Cost $14.35 Unrealized -28.7%

UNH UNITEDHEALTH GROUP INC 1.2%

Value $16.51M Shares 50,000 Est. Cost $318.07 Unrealized -2.9%

DXCM DEXCOM INC 0.9%

Value $11.61M Shares 175,000 Est. Cost $64.65 Unrealized +9.7%

CI THE CIGNA GROUP 0.8%

Value $11.01M Shares 40,000 Est. Cost $279.23 Unrealized +0.5%

INCY INCYTE CORP 0.7%

Value $9.877M Shares 100,000 Est. Cost $79.04 Unrealized +30.5%

LEGN LEGEND BIOTECH CORP 0.4%

Value $4.674M Shares 215,000 Est. Cost $21.74 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
RNAM	AVIDITY BIOSCIENCES INC	1,000,000	$72.13M	5.5%	$14.11	+415.0%	—	05370A108
SPRY	ARS PHARMACEUTICALS INC	1,600,000	$18.64M	1.4%	$14.35	-28.7%	—	82835W108
UNH	UNITEDHEALTH GROUP INC	50,000	$16.51M	1.2%	$318.07	-2.9%	—	91324P102
DXCM	DEXCOM INC	175,000	$11.61M	0.9%	$64.65	+9.7%	—	252131107
CI	THE CIGNA GROUP	40,000	$11.01M	0.8%	$279.23	+0.5%	—	125523100
INCY	INCYTE CORP	100,000	$9.877M	0.7%	$79.04	+30.5%	—	45337C102
LEGN	LEGEND BIOTECH CORP	215,000	$4.674M	0.4%	$21.74	—	—	52490G102

Decreased Positions (4)

ILMN ILLUMINA INC 4.9%

Value $65.33M (-17.0%) Shares 530,000 (-11.7%) Est. Cost $116.59 Unrealized +16.2%

BEAM BEAM THERAPEUTICS INC 2.4%

Value $32.17M (-27.5%) Shares 1,350,000 (-15.6%) Est. Cost $36.48 Unrealized -20.0%

GH GUARDANT HEALTH INC 2.2%

Value $29.1M (-25.0%) Shares 315,000 (-17.1%) Est. Cost $72.99 Unrealized +47.2%

PACB PACIFIC BIOSCIENCES CALIF IN 0.1%

Value $955K (-87.9%) Shares 723,767 (-82.9%) Est. Cost $3.55 Unrealized -43.0%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ILMN	ILLUMINA INC	530,000 (-11.7%)	$65.33M (-17.0%)	4.9%	$116.59	+16.2%	COM	452327109
BEAM	BEAM THERAPEUTICS INC	1,350,000 (-15.6%)	$32.17M (-27.5%)	2.4%	$36.48	-20.0%	COM	07373V105
GH	GUARDANT HEALTH INC	315,000 (-17.1%)	$29.1M (-25.0%)	2.2%	$72.99	+47.2%	COM	40131M109
PACB	PACIFIC BIOSCIENCES CALIF IN	723,767 (-82.9%)	$955K (-87.9%)	0.1%	$3.55	-43.0%	COM	69404D108

Unchanged Positions (20)

WGS GENEDX HOLDINGS CORP 14.6%

Value $193M Shares 3,007,164 Est. Cost $9.11 Unrealized +1009.6%

RVMD REVOLUTION MEDICINES INC 19.0%

Value $251M Shares 2,577,333 Est. Cost $25.89 Unrealized +297.8%

LAB STANDARD BIOTOOLS INC 6.2%

Value $81.62M Shares 88,783,856 Est. Cost $2.16 Unrealized -37.6%

BLFS BIOLIFE SOLUTIONS INC 8.6%

Value $114M Shares 5,957,165 Est. Cost $19.43 Unrealized +21.4%

GPCR STRUCTURE THERAPEUTICS INC 4.3%

Value $56.63M Shares 1,175,000 Est. Cost $28.16 Unrealized —

MAZE MAZE THERAPEUTICS INC 1.7%

Value $22.65M Shares 758,857 Est. Cost $12.04 Unrealized +265.8%

ALNY ALNYLAM PHARMACEUTICALS INC 1.9%

Value $24.82M Shares 75,000 Est. Cost $219.27 Unrealized +61.1%

DNLI DENALI THERAPEUTICS INC 2.7%

Value $35.33M Shares 1,840,000 Est. Cost $22.98 Unrealized -14.6%

TEM TEMPUS AI INC 1.0%

Value $13.3M Shares 294,127 Est. Cost $70.04 Unrealized -12.6%

VCYT VERACYTE INC 0.7%

Value $8.9M Shares 276,308 Est. Cost $24.40 Unrealized +61.2%

SEPN SEPTERNA INC 1.0%

Value $13.3M Shares 553,268 Est. Cost $23.65 Unrealized +12.1%

IPSC CENTURY THERAPEUTICS INC 0.2%

Value $2.776M Shares 1,228,190 Est. Cost $10.97 Unrealized -82.4%

DGX QUEST DIAGNOSTICS INC 0.7%

Value $9.799M Shares 50,000 Est. Cost $182.07 Unrealized +4.7%

BBOT BRIDGEBIO ONCOLOGY THERAPEUT 0.2%

Value $2.527M Shares 282,312 Est. Cost $11.58 Unrealized —

ABSI ABSCI CORPORATION 0.2%

Value $2.92M Shares 973,260 Est. Cost $19.41 Unrealized -84.5%

CTNM CONTINEUM THERAPEUTICS INC 0.1%

Value $1.937M Shares 148,333 Est. Cost $16.10 Unrealized -17.1%

RXRX RECURSION PHARMACEUTICALS IN 0.0%

Value $508K Shares 165,323 Est. Cost $6.72 Unrealized -37.9%

DNA GINKGO BIOWORKS HOLDINGS INC 0.0%

Value $224K Shares 36,493 Est. Cost $10.02 Unrealized -6.9%

PRME PRIME MEDICINE INC 0.8%

Value $11.02M Shares 3,167,175 Est. Cost $4.73 Unrealized -19.6%

TNYA TENAYA THERAPEUTICS INC 0.0%

Value $251K Shares 361,969 Est. Cost $12.86 Unrealized -94.4%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
WGS	GENEDX HOLDINGS CORP	3,007,164	$193M	14.6%	$9.11	+1009.6%	COM CL A	81663L200
RVMD	REVOLUTION MEDICINES INC	2,577,333	$251M	19.0%	$25.89	+297.8%	COM	76155X100
LAB	STANDARD BIOTOOLS INC	88,783,856	$81.62M	6.2%	$2.16	-37.6%	COM	34385P108
BLFS	BIOLIFE SOLUTIONS INC	5,957,165	$114M	8.6%	$19.43	+21.4%	COM NEW	09062W204
GPCR	STRUCTURE THERAPEUTICS INC	1,175,000	$56.63M	4.3%	$28.16	—	SPONSORED ADS	86366E106
MAZE	MAZE THERAPEUTICS INC	758,857	$22.65M	1.7%	$12.04	+265.8%	COM	578784100
ALNY	ALNYLAM PHARMACEUTICALS INC	75,000	$24.82M	1.9%	$219.27	+61.1%	COM	02043Q107
DNLI	DENALI THERAPEUTICS INC	1,840,000	$35.33M	2.7%	$22.98	-14.6%	COM	24823R105
TEM	TEMPUS AI INC	294,127	$13.3M	1.0%	$70.04	-12.6%	CL A	88023B103
VCYT	VERACYTE INC	276,308	$8.9M	0.7%	$24.40	+61.2%	COM	92337F107
SEPN	SEPTERNA INC	553,268	$13.3M	1.0%	$23.65	+12.1%	COM	81734D104
IPSC	CENTURY THERAPEUTICS INC	1,228,190	$2.776M	0.2%	$10.97	-82.4%	COM	15673T100
DGX	QUEST DIAGNOSTICS INC	50,000	$9.799M	0.7%	$182.07	+4.7%	COM	74834L100
BBOT	BRIDGEBIO ONCOLOGY THERAPEUT	282,312	$2.527M	0.2%	$11.58	—	COM NEW	107924102
ABSI	ABSCI CORPORATION	973,260	$2.92M	0.2%	$19.41	-84.5%	COM	00091E109
CTNM	CONTINEUM THERAPEUTICS INC	148,333	$1.937M	0.1%	$16.10	-17.1%	CL A	21217B100
RXRX	RECURSION PHARMACEUTICALS IN	165,323	$508K	0.0%	$6.72	-37.9%	CL A	75629V104
DNA	GINKGO BIOWORKS HOLDINGS INC	36,493	$224K	0.0%	$10.02	-6.9%	CL A NEW	37611X209
PRME	PRIME MEDICINE INC	3,167,175	$11.02M	0.8%	$4.73	-19.6%	COM	74168J101
TNYA	TENAYA THERAPEUTICS INC	361,969	$251K	0.0%	$12.86	-94.4%	COM	87990A106