Casdin Capital, LLC Diversified Active

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
TXG	10X GENOMICS INC	1,400,000	$22,834	1.4%	$15.11	0.0%	CL A COM	88025U109
DXCM	DEXCOM INC	175,000	$11,615	0.7%	$64.65	0.0%	COM	252131107
SRRK	SCHOLAR ROCK HLDG CORP	260,000	$11,453	0.7%	$37.51	0.0%	COM	80706P103
CI	THE CIGNA GROUP	40,000	$11,009	0.7%	$279.23	0.0%	COM	125523100
DGX	QUEST DIAGNOSTICS INC	50,000	$8,677	0.5%	$182.07	0.0%	COM	74834L100
TSHA	TAYSHA GENE THERAPIES INC	1,500,000	$8,250	0.5%	$4.86	0.0%	COM SHS	877619106
LEGN	LEGEND BIOTECH CORP	215,000	$4,674	0.3%	$21.74	—	SPONSORED ADS	52490G102

Increased Positions (9)

RLAY RELAY THERAPEUTICS INC 6.8%

Value ($000) $110,010 (+85.8%) Shares 13,003,574 (+14.7%) Est. Cost $15.13 Unrealized -52.8%

GH GUARDANT HEALTH INC 2.4%

Value ($000) $38,813 (+521.2%) Shares 380,000 (+280.0%) Est. Cost $72.99 Unrealized +22.6%

ILMN ILLUMINA INC 4.9%

Value ($000) $78,696 (+57.8%) Shares 600,000 (+14.3%) Est. Cost $116.59 Unrealized +0.7%

DNLI DENALI THERAPEUTICS INC 1.9%

Value ($000) $30,378 (+135.1%) Shares 1,840,000 (+106.7%) Est. Cost $22.98 Unrealized -26.5%

LAB STANDARD BIOTOOLS INC 7.1%

Value ($000) $113,643 (+12.7%) Shares 88,783,856 (+14.5%) Est. Cost $2.16 Unrealized -37.9%

UNH UNITEDHEALTH GROUP INC 1.0%

Value ($000) $16,506 (+91.2%) Shares 50,000 (+100.0%) Est. Cost $318.07 Unrealized +6.0%

PACB PACIFIC BIOSCIENCES CALIF IN 0.5%

Value ($000) $7,898 (+752.6%) Shares 4,223,767 (+483.6%) Est. Cost $3.55 Unrealized -45.9%

ALNY ALNYLAM PHARMACEUTICALS INC 1.9%

Value ($000) $29,824 (+18.9%) Shares 75,000 (+36.4%) Est. Cost $219.27 Unrealized +101.8%

HIMS HIMS & HERS HEALTH INC 0.8%

Value ($000) $12,501 (-4.2%) Shares 385,000 (+67.4%) Est. Cost $40.06 Unrealized +6.9%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
RLAY	RELAY THERAPEUTICS INC	13,003,574 (+14.7%)	$110,010 (+85.8%)	6.8%	$15.13	-52.8%	COM	75943R102
GH	GUARDANT HEALTH INC	380,000 (+280.0%)	$38,813 (+521.2%)	2.4%	$72.99	+22.6%	COM	40131M109
ILMN	ILLUMINA INC	600,000 (+14.3%)	$78,696 (+57.8%)	4.9%	$116.59	+0.7%	COM	452327109
DNLI	DENALI THERAPEUTICS INC	1,840,000 (+106.7%)	$30,378 (+135.1%)	1.9%	$22.98	-26.5%	COM	24823R105
LAB	STANDARD BIOTOOLS INC	88,783,856 (+14.5%)	$113,643 (+12.7%)	7.1%	$2.16	-37.9%	COM	34385P108
UNH	UNITEDHEALTH GROUP INC	50,000 (+100.0%)	$16,506 (+91.2%)	1.0%	$318.07	+6.0%	COM	91324P102
PACB	PACIFIC BIOSCIENCES CALIF IN	4,223,767 (+483.6%)	$7,898 (+752.6%)	0.5%	$3.55	-45.9%	COM	69404D108
ALNY	ALNYLAM PHARMACEUTICALS INC	75,000 (+36.4%)	$29,824 (+18.9%)	1.9%	$219.27	+101.8%	COM	02043Q107
HIMS	HIMS & HERS HEALTH INC	385,000 (+67.4%)	$12,501 (-4.2%)	0.8%	$40.06	+6.9%	COM CL A	433000106

Exited Positions (1)

EXAS EXACT SCIENCES CORP 0.3%

Value ($000) $4,924 Shares 90,000 Est. Cost $74.77 Unrealized +7.4%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
EXAS	EXACT SCIENCES CORP	90,000	$4,924	0.3%	$74.77	+7.4%	—	30063P105

Decreased Positions (4)

RVMD REVOLUTION MEDICINES INC 12.8%

Value ($000) $205,285 (+66.0%) Shares 2,577,333 (-2.6%) Est. Cost $25.89 Unrealized +153.2%

GPCR STRUCTURE THERAPEUTICS INC 5.1%

Value ($000) $81,721 (+87.7%) Shares 1,175,000 (-24.4%) Est. Cost $28.16 Unrealized —

BLFS BIOLIFE SOLUTIONS INC 8.9%

Value ($000) $144,044 (-15.8%) Shares 5,957,165 (-11.2%) Est. Cost $19.43 Unrealized +34.7%

RNA AVIDITY BIOSCIENCES INC 4.5%

Value ($000) $72,130 (-7.0%) Shares 1,000,000 (-43.8%) Est. Cost $14.11 Unrealized +357.9%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
RVMD	REVOLUTION MEDICINES INC	2,577,333 (-2.6%)	$205,285 (+66.0%)	12.8%	$25.89	+153.2%	COM	76155X100
GPCR	STRUCTURE THERAPEUTICS INC	1,175,000 (-24.4%)	$81,721 (+87.7%)	5.1%	$28.16	—	SPONSORED ADS	86366E106
BLFS	BIOLIFE SOLUTIONS INC	5,957,165 (-11.2%)	$144,044 (-15.8%)	8.9%	$19.43	+34.7%	COM NEW	09062W204
RNA	AVIDITY BIOSCIENCES INC	1,000,000 (-43.8%)	$72,130 (-7.0%)	4.5%	$14.11	+357.9%	COM	05370A108

Unchanged Positions (18)

WGS GENEDX HOLDINGS CORP 24.3%

Value ($000) $391,112 Shares 3,007,164 Est. Cost $9.11 Unrealized +1406.1%

MAZE MAZE THERAPEUTICS INC 2.0%

Value ($000) $31,439 Shares 758,857 Est. Cost $12.04 Unrealized +185.5%

PRME PRIME MEDICINE INC 0.7%

Value ($000) $10,990 Shares 3,167,175 Est. Cost $4.73 Unrealized -6.0%

TEM TEMPUS AI INC 1.1%

Value ($000) $17,368 Shares 294,127 Est. Cost $70.04 Unrealized +11.7%

BEAM BEAM THERAPEUTICS INC 2.8%

Value ($000) $44,352 Shares 1,600,000 Est. Cost $36.48 Unrealized -30.1%

SEPN SEPTERNA INC 1.0%

Value ($000) $15,425 Shares 553,268 Est. Cost $23.65 Unrealized +1.0%

NGNE NEUROGENE INC 1.7%

Value ($000) $26,684 Shares 1,295,361 Est. Cost $27.94 Unrealized -10.9%

SPRY ARS PHARMACEUTICALS INC 1.2%

Value ($000) $18,640 Shares 1,600,000 Est. Cost $14.35 Unrealized -32.2%

VCYT VERACYTE INC 0.7%

Value ($000) $11,633 Shares 276,308 Est. Cost $24.40 Unrealized +65.2%

INCY INCYTE CORP 0.6%

Value ($000) $9,877 Shares 100,000 Est. Cost $79.04 Unrealized +22.4%

GLUE MONTE ROSA THERAPEUTICS INC 0.1%

Value ($000) $1,349 Shares 86,014 Est. Cost $20.37 Unrealized -33.8%

IPSC CENTURY THERAPEUTICS INC 0.1%

Value ($000) $1,222 Shares 1,228,190 Est. Cost $10.97 Unrealized -94.4%

ABSI ABSCI CORPORATION 0.2%

Value ($000) $3,397 Shares 973,260 Est. Cost $19.41 Unrealized -81.2%

TNYA TENAYA THERAPEUTICS INC 0.0%

Value ($000) $258 Shares 361,969 Est. Cost $12.86 Unrealized -89.4%

BBOT BRIDGEBIO ONCOLOGY THERAPEUT 0.2%

Value ($000) $3,535 Shares 282,312 Est. Cost $11.58 Unrealized —

DNA GINKGO BIOWORKS HOLDINGS INC 0.0%

Value ($000) $303 Shares 36,493 Est. Cost $10.02 Unrealized +7.4%

RXRX RECURSION PHARMACEUTICALS IN 0.0%

Value ($000) $676 Shares 165,323 Est. Cost $6.72 Unrealized -26.3%

CTNM CONTINEUM THERAPEUTICS INC 0.1%

Value ($000) $1,695 Shares 148,333 Est. Cost $16.10 Unrealized -29.2%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
WGS	GENEDX HOLDINGS CORP	3,007,164	$391,112	24.3%	$9.11	+1406.1%	COM CL A	81663L200
MAZE	MAZE THERAPEUTICS INC	758,857	$31,439	2.0%	$12.04	+185.5%	COM	578784100
PRME	PRIME MEDICINE INC	3,167,175	$10,990	0.7%	$4.73	-6.0%	COM	74168J101
TEM	TEMPUS AI INC	294,127	$17,368	1.1%	$70.04	+11.7%	CL A	88023B103
BEAM	BEAM THERAPEUTICS INC	1,600,000	$44,352	2.8%	$36.48	-30.1%	COM	07373V105
SEPN	SEPTERNA INC	553,268	$15,425	1.0%	$23.65	+1.0%	COM	81734D104
NGNE	NEUROGENE INC	1,295,361	$26,684	1.7%	$27.94	-10.9%	COM	64135M105
SPRY	ARS PHARMACEUTICALS INC	1,600,000	$18,640	1.2%	$14.35	-32.2%	COM	82835W108
VCYT	VERACYTE INC	276,308	$11,633	0.7%	$24.40	+65.2%	COM	92337F107
INCY	INCYTE CORP	100,000	$9,877	0.6%	$79.04	+22.4%	COM	45337C102
GLUE	MONTE ROSA THERAPEUTICS INC	86,014	$1,349	0.1%	$20.37	-33.8%	COM	61225M102
IPSC	CENTURY THERAPEUTICS INC	1,228,190	$1,222	0.1%	$10.97	-94.4%	COM	15673T100
ABSI	ABSCI CORPORATION	973,260	$3,397	0.2%	$19.41	-81.2%	COM	00091E109
TNYA	TENAYA THERAPEUTICS INC	361,969	$258	0.0%	$12.86	-89.4%	COM	87990A106
BBOT	BRIDGEBIO ONCOLOGY THERAPEUT	282,312	$3,535	0.2%	$11.58	—	COM NEW	107924102
DNA	GINKGO BIOWORKS HOLDINGS INC	36,493	$303	0.0%	$10.02	+7.4%	CL A NEW	37611X209
RXRX	RECURSION PHARMACEUTICALS IN	165,323	$676	0.0%	$6.72	-26.3%	CL A	75629V104
CTNM	CONTINEUM THERAPEUTICS INC	148,333	$1,695	0.1%	$16.10	-29.2%	CL A	21217B100