EcoR1 Capital, LLC Quant / Systematic

Location: San Francisco, CA

CIK: 0001587114 · Show all filings

Period: Q1 2026 (← Previous) (Next →)

Filing Date: May 15, 2026

Total Value: $2.356B (100.0% shares, 0.0% debt)

Holdings (30)

ZYME ZYMEWORKS INC 24.4%

Value $575M Shares 22,970,388 Est. Cost $9.83 Unrealized +137.7%

ANAB ANAPTYSBIO INC 18.5%

Value $437M Shares 7,880,094 Est. Cost $23.54 Unrealized +109.7%

JAZZ JAZZ PHARMACEUTICALS PLC 13.7%

Value $323M Shares 1,706,469 Est. Cost $120.72 Unrealized +40.0%

CNTA CENTESSA PHARMACEUTICALS PLC 10.1%

Value $238M Shares 6,000,000 Est. Cost $32.01 Unrealized —

CRNX CRINETICS PHARMACEUTICALS IN 6.6%

Value $156M Shares 4,288,120 Est. Cost $32.41 Unrealized +51.8%

AKTS AKTIS ONCOLOGY INC 3.7%

Value $86.31M Shares 4,824,469 Est. Cost $17.89 Unrealized —

ORIC ORIC PHARMACEUTICALS INC 3.6%

Value $85.25M Shares 6,728,116 Est. Cost $15.26 Unrealized -29.5%

CGON CG ONCOLOGY INC 3.2%

Value $74.58M Shares 1,102,000 Est. Cost $44.69 Unrealized +17.3%

CRSP CRISPR THERAPEUTICS AG 2.8%

Value $66.09M Shares 1,389,276 Est. Cost $71.59 Unrealized -25.3%

ETON ETON PHARMACEUTICALS INC 2.3%

Value $53.6M Shares 2,171,938 Est. Cost $9.47 Unrealized +68.9%

GLPG GALAPAGOS NV 2.1%

Value $50.01M Shares 1,667,119 Est. Cost $32.49 Unrealized —

XNCR XENCOR INC 1.1%

Value $26.33M Shares 2,183,000 Est. Cost $32.11 Unrealized -60.6%

NGNE NEUROGENE INC 1.1%

Value $25.63M Shares 1,271,342 Est. Cost $14.32 Unrealized +26.7%

BBOT BRIDGEBIO ONCOLOGY THERAPEUT 1.1%

Value $25.27M Shares 2,823,126 Est. Cost $11.58 Unrealized —

MBX MBX BIOSCIENCES INC 1.0%

Value $23.19M Shares 777,000 Est. Cost $18.46 Unrealized +99.5%

RLAY RELAY THERAPEUTICS INC 0.8%

Value $18.95M Shares 1,904,762 Est. Cost $8.30 Unrealized 0.0%

CNTA CENTESSA PHARMACEUTICALS PLC 0.7%

Value $16.32M Shares 410,800 Est. Cost $32.01 Unrealized —

ZBIO ZENAS BIOPHARMA INC 0.7%

Value $15.43M Shares 789,500 Est. Cost $32.89 Unrealized -33.5%

ERAS ERASCA INC 0.6%

Value $14.56M Shares 900,000 Est. Cost $10.02 Unrealized 0.0%

EIKN EIKON THERAPEUTICS INC 0.3%

Value $7.751M Shares 732,606 Est. Cost $10.58 Unrealized —

REPL REPLIMUNE GROUP INC 0.3%

Value $7.65M Shares 1,000,000 Est. Cost $7.81 Unrealized 0.0%

ZURA ZURA BIO LTD 0.3%

Value $7.019M Shares 1,179,715 Est. Cost $5.88 Unrealized 0.0%

PHAT PHATHOM PHARMACEUTICALS INC 0.3%

Value $6.944M Shares 625,000 Est. Cost $13.69 Unrealized 0.0%

MREO MEREO BIOPHARMA GROUP PLC 0.2%

Value $4.412M Shares 13,368,855 Est. Cost $0.38 Unrealized —

STOK STOKE THERAPEUTICS INC 0.1%

Value $3.256M Shares 100,000 Est. Cost $31.83 Unrealized 0.0%

PRLD PRELUDE THERAPEUTICS INC 0.1%

Value $3.239M Shares 947,049 Est. Cost $2.30 Unrealized 0.0%

IBIO IBIO INC 0.1%

Value $3.008M Shares 1,583,000 Est. Cost $1.36 Unrealized +69.5%

HLXC HELIX ACQUISITION CORP III USD 0.1%

Value $2.032M Shares 200,000 Est. Cost $10.16 Unrealized —

ATRA ATARA BIOTHERAPEUTICS INC 0.0%

Value $471K Shares 99,593 Est. Cost $13.39 Unrealized -50.8%

SRZNW SURROZEN INC 0.0%

Value $129K Shares 4,444 Est. Cost $7.07 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ZYME	ZYMEWORKS INC	22,970,388	$575M	24.4%	$9.83	+137.7%	COM	98985Y108
ANAB	ANAPTYSBIO INC	7,880,094	$437M	18.5%	$23.54	+109.7%	COM	032724106
JAZZ	JAZZ PHARMACEUTICALS PLC	1,706,469	$323M	13.7%	$120.72	+40.0%	SHS USD	G50871105
CNTA	CENTESSA PHARMACEUTICALS PLC	6,000,000	$238M	10.1%	$32.01	—	SPONSORED ADS	152309100
CRNX	CRINETICS PHARMACEUTICALS IN	4,288,120	$156M	6.6%	$32.41	+51.8%	COM	22663K107
AKTS	AKTIS ONCOLOGY INC	4,824,469	$86.31M	3.7%	$17.89	—	COM ADDED	01021M104
ORIC	ORIC PHARMACEUTICALS INC	6,728,116	$85.25M	3.6%	$15.26	-29.5%	COM	68622P109
CGON	CG ONCOLOGY INC	1,102,000	$74.58M	3.2%	$44.69	+17.3%	COM	156944100
CRSP	CRISPR THERAPEUTICS AG	1,389,276	$66.09M	2.8%	$71.59	-25.3%	NAMEN AKT	H17182108
ETON	ETON PHARMACEUTICALS INC	2,171,938	$53.6M	2.3%	$9.47	+68.9%	COM	29772L108
GLPG	GALAPAGOS NV	1,667,119	$50.01M	2.1%	$32.49	—	SPON ADR	36315X101
XNCR	XENCOR INC	2,183,000	$26.33M	1.1%	$32.11	-60.6%	COM	98401F105
NGNE	NEUROGENE INC	1,271,342	$25.63M	1.1%	$14.32	+26.7%	COM	64135M105
BBOT	BRIDGEBIO ONCOLOGY THERAPEUT	2,823,126	$25.27M	1.1%	$11.58	—	COM NEW	107924102
MBX	MBX BIOSCIENCES INC	777,000	$23.19M	1.0%	$18.46	+99.5%	COM	55287L101
RLAY	RELAY THERAPEUTICS INC	1,904,762	$18.95M	0.8%	$8.30	0.0%	COM	75943R102
CNTA	CENTESSA PHARMACEUTICALS PLC	410,800	$16.32M	0.7%	$32.01	—	Call	152309100
ZBIO	ZENAS BIOPHARMA INC	789,500	$15.43M	0.7%	$32.89	-33.5%	COM	98937L105
ERAS	ERASCA INC	900,000	$14.56M	0.6%	$10.02	0.0%	COM	29479A108
EIKN	EIKON THERAPEUTICS INC	732,606	$7.751M	0.3%	$10.58	—	COM ADDED	282564103
REPL	REPLIMUNE GROUP INC	1,000,000	$7.65M	0.3%	$7.81	0.0%	COM	76029N106
ZURA	ZURA BIO LTD	1,179,715	$7.019M	0.3%	$5.88	0.0%	CLASS A ORD SHS	G9TY5A101
PHAT	PHATHOM PHARMACEUTICALS INC	625,000	$6.944M	0.3%	$13.69	0.0%	COM	71722W107
MREO	MEREO BIOPHARMA GROUP PLC	13,368,855	$4.412M	0.2%	$0.38	—	SPON ADS	589492107
STOK	STOKE THERAPEUTICS INC	100,000	$3.256M	0.1%	$31.83	0.0%	COM	86150R107
PRLD	PRELUDE THERAPEUTICS INC	947,049	$3.239M	0.1%	$2.30	0.0%	COM	74065P101
IBIO	IBIO INC	1,583,000	$3.008M	0.1%	$1.36	+69.5%	COM NEW	451033708
HLXC	HELIX ACQUISITION CORP III USD	200,000	$2.032M	0.1%	$10.16	—	CL A ORD SHS ADDED	G4444S107
ATRA	ATARA BIOTHERAPEUTICS INC	99,593	$471K	0.0%	$13.39	-50.8%	COM NEW	046513206
SRZNW	SURROZEN INC	4,444	$129K	0.0%	$7.07	—	*W EXP 08/01/203	86889P117