EcoR1 Capital, LLC Quant / Systematic

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
CGON	CG ONCOLOGY INC	772,000	$32,053	1.5%	$41.38	0.0%	COM	156944100
ZBIO	ZENAS BIOPHARMA INC	789,500	$28,667	1.3%	$32.89	0.0%	COM	98937L105
GPCR	STRUCTURE THERAPEUTICS INC	334,380	$23,256	1.1%	$69.55	—	SPONSORED ADS	86366E106
PCVX	VAXCYTE INC	450,000	$20,763	0.9%	$44.73	0.0%	COM	92243G108
CGON	CG ONCOLOGY INC	292,800	$12,157	0.6%	$41.38	0.0%	CALL	156944100
MNKD	MANNKIND CORP	1,660,000	$9,412	0.4%	$5.51	0.0%	COM NEW	56400P706
EOLS	EVOLUS INC	675,000	$4,489	0.2%	$6.77	0.0%	COM	30052C107
IBIO	IBIO INC	2,228,000	$4,300	0.2%	$1.36	0.0%	COM NEW	451033708
MREO	MEREO BIOPHARMA GROUP PLC	7,856,466	$3,274	0.1%	$0.42	—	SPON ADS	589492107
CAMP	CAMP4 THERAPEUTICS CORP	325,000	$1,992	0.1%	$4.25	0.0%	COM	13463J101
XNCR	XENCOR INC	67,500	$1,033	0.0%	$32.11	-53.5%	CALL	98401F105

Increased Positions (2)

CNTA CENTESSA PHARMACEUTICALS PLC 3.5%

Value ($000) $77,906 (+484.1%) Shares 3,115,000 (+466.4%) Est. Cost $24.88 Unrealized —

VYGR VOYAGER THERAPEUTICS INC 0.7%

Value ($000) $15,731 (+402.5%) Shares 4,002,847 (+497.2%) Est. Cost $3.88 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
CNTA	CENTESSA PHARMACEUTICALS PLC	3,115,000 (+466.4%)	$77,906 (+484.1%)	3.5%	$24.88	—	SPONSORED ADS	152309100
VYGR	VOYAGER THERAPEUTICS INC	4,002,847 (+497.2%)	$15,731 (+402.5%)	0.7%	$3.88	—	COM	92915B106

Exited Positions (11)

QURE UNIQURE NV 10.6%

Value ($000) $232,836 Shares 3,988,971 Est. Cost $9.43 Unrealized +309.3%

TNGX TANGO THERAPEUTICS INC 4.1%

Value ($000) $89,298 Shares 10,630,736 Est. Cost $7.06 Unrealized +22.1%

APLS APELLIS PHARMACEUTICALS INC 3.5%

Value ($000) $78,009 Shares 3,447,156 Est. Cost $43.04 Unrealized -45.5%

MDGL MADRIGAL PHARMACEUTICALS INC 1.6%

Value ($000) $34,400 Shares 75,000 Est. Cost $235.62 Unrealized +116.8%

RNA AVIDITY BIOSCIENCES INC 1.5%

Value ($000) $33,331 Shares 765,000 Est. Cost $24.25 Unrealized +166.4%

ALKS ALKERMES PLC 0.7%

Value ($000) $15,000 Shares 500,000 Est. Cost $29.76 Unrealized +0.6%

— METSERA INC 0.6%

Value ($000) $14,209 Shares 271,529 Est. Cost $28.22 Unrealized —

PRME PRIME MEDICINE INC 0.4%

Value ($000) $8,550 Shares 1,543,326 Est. Cost $4.06 Unrealized +9.5%

KURA KURA ONCOLOGY INC 0.4%

Value ($000) $7,722 Shares 872,500 Est. Cost $14.07 Unrealized -25.4%

PEPG PEPGEN INC 0.2%

Value ($000) $3,696 Shares 800,000 Est. Cost $1.61 Unrealized +222.0%

CMPS COMPASS PATHWAYS PLC 0.1%

Value ($000) $1,519 Shares 265,137 Est. Cost $5.73 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
QURE	UNIQURE NV	3,988,971	$232,836	10.6%	$9.43	+309.3%	—	N90064101
TNGX	TANGO THERAPEUTICS INC	10,630,736	$89,298	4.1%	$7.06	+22.1%	—	87583X109
APLS	APELLIS PHARMACEUTICALS INC	3,447,156	$78,009	3.5%	$43.04	-45.5%	—	03753U106
MDGL	MADRIGAL PHARMACEUTICALS INC	75,000	$34,400	1.6%	$235.62	+116.8%	—	558868105
RNA	AVIDITY BIOSCIENCES INC	765,000	$33,331	1.5%	$24.25	+166.4%	—	05370A108
ALKS	ALKERMES PLC	500,000	$15,000	0.7%	$29.76	+0.6%	—	G01767105
—	METSERA INC	271,529	$14,209	0.6%	$28.22	—	—	59267L107
PRME	PRIME MEDICINE INC	1,543,326	$8,550	0.4%	$4.06	+9.5%	—	74168J101
KURA	KURA ONCOLOGY INC	872,500	$7,722	0.4%	$14.07	-25.4%	—	50127T109
PEPG	PEPGEN INC	800,000	$3,696	0.2%	$1.61	+222.0%	—	713317105
CMPS	COMPASS PATHWAYS PLC	265,137	$1,519	0.1%	$5.73	—	—	20451W101

Decreased Positions (3)

XNCR XENCOR INC 2.3%

Value ($000) $49,775 (-30.9%) Shares 3,251,112 (-47.1%) Est. Cost $32.11 Unrealized -53.5%

IMNM IMMUNOME INC 2.8%

Value ($000) $61,338 (+28.4%) Shares 2,855,590 (-30.0%) Est. Cost $8.38 Unrealized +109.5%

SRZNW SURROZEN INC 0.0%

Value ($000) $100 (-88.3%) Shares 4,444 (-93.3%) Est. Cost $7.07 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
XNCR	XENCOR INC	3,251,112 (-47.1%)	$49,775 (-30.9%)	2.3%	$32.11	-53.5%	COM	98401F105
IMNM	IMMUNOME INC	2,855,590 (-30.0%)	$61,338 (+28.4%)	2.8%	$8.38	+109.5%	COM	45257U108
SRZNW	SURROZEN INC	4,444 (-93.3%)	$100 (-88.3%)	0.0%	$7.07	—	*W EXP 08/01/203	86889P117

Unchanged Positions (14)

ZYME ZYMEWORKS INC 27.4%

Value ($000) $604,810 Shares 22,970,388 Est. Cost $9.83 Unrealized +121.8%

ANAB ANAPTYSBIO INC 17.3%

Value ($000) $382,027 Shares 7,880,094 Est. Cost $23.54 Unrealized +65.6%

JAZZ JAZZ PHARMACEUTICALS PLC 13.2%

Value ($000) $290,100 Shares 1,706,469 Est. Cost $120.72 Unrealized +27.0%

MBX MBX BIOSCIENCES INC 3.0%

Value ($000) $66,978 Shares 2,123,604 Est. Cost $18.46 Unrealized +31.5%

ORIC ORIC PHARMACEUTICALS INC 2.5%

Value ($000) $55,036 Shares 6,728,116 Est. Cost $15.26 Unrealized -24.6%

CRNX CRINETICS PHARMACEUTICALS IN 9.1%

Value ($000) $199,612 Shares 4,288,120 Est. Cost $32.41 Unrealized +37.4%

CRSP CRISPR THERAPEUTICS AG 3.3%

Value ($000) $72,854 Shares 1,389,276 Est. Cost $71.59 Unrealized -16.3%

ETON ETON PHARMACEUTICALS INC 1.6%

Value ($000) $34,336 Shares 2,030,544 Est. Cost $9.01 Unrealized +95.2%

— NUVATION BIO INC 0.4%

Value ($000) $8,631 Shares 963,333 Est. Cost $10.45 Unrealized —

NGNE NEUROGENE INC 1.2%

Value ($000) $26,190 Shares 1,271,342 Est. Cost $14.32 Unrealized +73.8%

GLPG GALAPAGOS NV 2.5%

Value ($000) $54,515 Shares 1,667,119 Est. Cost $32.49 Unrealized —

BBOT BRIDGEBIO ONCOLOGY THERAPEUT 1.6%

Value ($000) $35,346 Shares 2,823,126 Est. Cost $11.58 Unrealized —

AQST AQUESTIVE THERAPEUTICS INC 0.8%

Value ($000) $16,958 Shares 2,625,000 Est. Cost $4.32 Unrealized +44.1%

ATRA ATARA BIOTHERAPEUTICS INC 0.5%

Value ($000) $10,369 Shares 573,183 Est. Cost $13.39 Unrealized +11.5%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
ZYME	ZYMEWORKS INC	22,970,388	$604,810	27.4%	$9.83	+121.8%	COM	98985Y108
ANAB	ANAPTYSBIO INC	7,880,094	$382,027	17.3%	$23.54	+65.6%	COM	032724106
JAZZ	JAZZ PHARMACEUTICALS PLC	1,706,469	$290,100	13.2%	$120.72	+27.0%	SHS USD	G50871105
MBX	MBX BIOSCIENCES INC	2,123,604	$66,978	3.0%	$18.46	+31.5%	COM	55287L101
ORIC	ORIC PHARMACEUTICALS INC	6,728,116	$55,036	2.5%	$15.26	-24.6%	COM	68622P109
CRNX	CRINETICS PHARMACEUTICALS IN	4,288,120	$199,612	9.1%	$32.41	+37.4%	COM	22663K107
CRSP	CRISPR THERAPEUTICS AG	1,389,276	$72,854	3.3%	$71.59	-16.3%	NAMEN AKT	H17182108
ETON	ETON PHARMACEUTICALS INC	2,030,544	$34,336	1.6%	$9.01	+95.2%	COM	29772L108
—	NUVATION BIO INC	963,333	$8,631	0.4%	$10.45	—	*W EXP 02/10/202	67080N119
NGNE	NEUROGENE INC	1,271,342	$26,190	1.2%	$14.32	+73.8%	COM	64135M105
GLPG	GALAPAGOS NV	1,667,119	$54,515	2.5%	$32.49	—	SPON ADR	36315X101
BBOT	BRIDGEBIO ONCOLOGY THERAPEUT	2,823,126	$35,346	1.6%	$11.58	—	COM NEW	107924102
AQST	AQUESTIVE THERAPEUTICS INC	2,625,000	$16,958	0.8%	$4.32	+44.1%	COM	03843E104
ATRA	ATARA BIOTHERAPEUTICS INC	573,183	$10,369	0.5%	$13.39	+11.5%	COM NEW	046513206