Samsara BioCapital, LLC Diversified Active

CIK: 0001744967 · Show all filings

Period: Q4 2025 (← Previous)

Filing Date: Feb 17, 2026

Total Value ($000): $969,257 (100.0% shares, 0.0% debt)

Holdings (21)

New Positions (4)

IVA INVENTIVA SA 2.5%

Value ($000) $24,156 Shares 5,194,805 Est. Cost $4.65 Unrealized —

RANI RANI THERAPEUTICS HLDGS INC 1.2%

Value ($000) $11,475 Shares 8,500,000 Est. Cost $1.51 Unrealized 0.0%

XFOR X4 PHARMACEUTICALS INC 0.8%

Value ($000) $7,840 Shares 1,960,000 Est. Cost $3.63 Unrealized 0.0%

STRO SUTRO BIOPHARMA INC 0.2%

Value ($000) $2,366 Shares 204,503 Est. Cost $9.49 Unrealized 0.0%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
IVA	INVENTIVA SA	5,194,805	$24,156	2.5%	$4.65	—	ADS	46124U107
RANI	RANI THERAPEUTICS HLDGS INC	8,500,000	$11,475	1.2%	$1.51	0.0%	COM CL A	753018100
XFOR	X4 PHARMACEUTICALS INC	1,960,000	$7,840	0.8%	$3.63	0.0%	COM NEW	98420X202
STRO	SUTRO BIOPHARMA INC	204,503	$2,366	0.2%	$9.49	0.0%	COM SHS	869367201

Increased Positions (5)

SRRK SCHOLAR ROCK HLDG CORP 31.3%

Value ($000) $303,842 (+45.4%) Shares 6,897,652 (+22.9%) Est. Cost $14.61 Unrealized +156.7%

KLRS KALARIS THERAPEUTICS INC 11.3%

Value ($000) $109,282 (+65.2%) Shares 12,948,081 (+13.1%) Est. Cost $9.40 Unrealized -32.0%

ALMS ALUMIS INC 5.8%

Value ($000) $56,188 (+193.3%) Shares 5,756,984 (+19.9%) Est. Cost $9.30 Unrealized -24.9%

JBIO JADE BIOSCIENCES INC 1.5%

Value ($000) $14,949 (+226.1%) Shares 968,798 (+82.4%) Est. Cost $23.56 Unrealized -50.2%

GOSS GOSSAMER BIO INC 2.3%

Value ($000) $22,390 (+38.9%) Shares 7,222,559 (+17.8%) Est. Cost $1.41 Unrealized +102.4%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
SRRK	SCHOLAR ROCK HLDG CORP	6,897,652 (+22.9%)	$303,842 (+45.4%)	31.3%	$14.61	+156.7%	COM	80706P103
KLRS	KALARIS THERAPEUTICS INC	12,948,081 (+13.1%)	$109,282 (+65.2%)	11.3%	$9.40	-32.0%	COM	482929106
ALMS	ALUMIS INC	5,756,984 (+19.9%)	$56,188 (+193.3%)	5.8%	$9.30	-24.9%	COM	022307102
JBIO	JADE BIOSCIENCES INC	968,798 (+82.4%)	$14,949 (+226.1%)	1.5%	$23.56	-50.2%	COM NEW	008064206
GOSS	GOSSAMER BIO INC	7,222,559 (+17.8%)	$22,390 (+38.9%)	2.3%	$1.41	+102.4%	COM	38341P102

Exited Positions (10)

LENZ LENZ THERAPEUTICS INC 1.6%

Value ($000) $15,977 Shares 343,012 Est. Cost $20.79 Unrealized +40.2%

— AVADEL PHARMACEUTICALS PLC 1.1%

Value ($000) $10,315 Shares 675,504 Est. Cost $14.06 Unrealized —

AURA AURA BIOSCIENCES INC 0.4%

Value ($000) $3,614 Shares 584,849 Est. Cost $5.85 Unrealized +1.5%

ZYME ZYMEWORKS INC 0.4%

Value ($000) $3,551 Shares 207,901 Est. Cost $8.72 Unrealized +150.1%

SRZN SURROZEN INC 0.3%

Value ($000) $3,110 Shares 241,400 Est. Cost $11.62 Unrealized +39.2%

RYTM RHYTHM PHARMACEUTICALS INC 0.3%

Value ($000) $3,058 Shares 30,285 Est. Cost $17.86 Unrealized +494.0%

— SUTRO BIOPHARMA INC 0.2%

Value ($000) $1,908 Shares 2,196,814 Est. Cost $7.26 Unrealized —

TERN TERNS PHARMACEUTICALS INC 0.1%

Value ($000) $1,018 Shares 135,573 Est. Cost $21.92 Unrealized +5.4%

BOLT BOLT BIOTHERAPEUTICS INC 0.0%

Value ($000) $260 Shares 48,830 Est. Cost $6.62 Unrealized -18.9%

SRZNW SURROZEN INC 0.0%

Value ($000) $2 Shares 99,999 Est. Cost $0.19 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
LENZ	LENZ THERAPEUTICS INC	343,012	$15,977	1.6%	$20.79	+40.2%	—	52635N103
—	AVADEL PHARMACEUTICALS PLC	675,504	$10,315	1.1%	$14.06	—	—	G29687103
AURA	AURA BIOSCIENCES INC	584,849	$3,614	0.4%	$5.85	+1.5%	—	05153U107
ZYME	ZYMEWORKS INC	207,901	$3,551	0.4%	$8.72	+150.1%	—	98985Y108
SRZN	SURROZEN INC	241,400	$3,110	0.3%	$11.62	+39.2%	—	86889P208
RYTM	RHYTHM PHARMACEUTICALS INC	30,285	$3,058	0.3%	$17.86	+494.0%	—	76243J105
—	SUTRO BIOPHARMA INC	2,196,814	$1,908	0.2%	$7.26	—	—	869367102
TERN	TERNS PHARMACEUTICALS INC	135,573	$1,018	0.1%	$21.92	+5.4%	—	880881107
BOLT	BOLT BIOTHERAPEUTICS INC	48,830	$260	0.0%	$6.62	-18.9%	—	097702203
SRZNW	SURROZEN INC	99,999	$2	0.0%	$0.19	—	—	86889P117

Decreased Positions (8)

MLYS MINERALYS THERAPEUTICS INC 22.0%

Value ($000) $213,059 (-10.3%) Shares 5,871,018 (-6.3%) Est. Cost $16.38 Unrealized +144.9%

CTNM CONTINEUM THERAPEUTICS INC 0.1%

Value ($000) $826 (-87.7%) Shares 72,245 (-87.4%) Est. Cost $16.10 Unrealized -29.2%

VTVT VTV THERAPEUTICS INC 1.2%

Value ($000) $11,937 (+36.5%) Shares 298,496 (-20.3%) Est. Cost $14.92 Unrealized +85.9%

ACLX ARCELLX INC 0.4%

Value ($000) $3,969 (-40.4%) Shares 60,873 (-25.0%) Est. Cost $16.49 Unrealized +383.8%

PVLA PALVELLA THERAPEUTICS INC NE 1.1%

Value ($000) $10,971 (-16.5%) Shares 104,817 (-50.0%) Est. Cost $15.71 Unrealized +443.1%

UPB UPSTREAM BIO INC 2.1%

Value ($000) $19,984 (+10.4%) Shares 736,047 (-23.5%) Est. Cost $22.33 Unrealized +11.5%

NKTX NKARTA INC 0.7%

Value ($000) $6,489 (-16.8%) Shares 3,507,666 (-6.9%) Est. Cost $21.30 Unrealized -90.6%

— NUVATION BIO INC 0.0%

Value ($000) $41 (+52.0%) Shares 124,119 (-6.9%) Est. Cost $0.28 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
MLYS	MINERALYS THERAPEUTICS INC	5,871,018 (-6.3%)	$213,059 (-10.3%)	22.0%	$16.38	+144.9%	COM	603170101
CTNM	CONTINEUM THERAPEUTICS INC	72,245 (-87.4%)	$826 (-87.7%)	0.1%	$16.10	-29.2%	CL A	21217B100
VTVT	VTV THERAPEUTICS INC	298,496 (-20.3%)	$11,937 (+36.5%)	1.2%	$14.92	+85.9%	CL A NEW	918385204
ACLX	ARCELLX INC	60,873 (-25.0%)	$3,969 (-40.4%)	0.4%	$16.49	+383.8%	COMMON STOCK	03940C100
PVLA	PALVELLA THERAPEUTICS INC NE	104,817 (-50.0%)	$10,971 (-16.5%)	1.1%	$15.71	+443.1%	COM	697947109
UPB	UPSTREAM BIO INC	736,047 (-23.5%)	$19,984 (+10.4%)	2.1%	$22.33	+11.5%	COM	91678A107
NKTX	NKARTA INC	3,507,666 (-6.9%)	$6,489 (-16.8%)	0.7%	$21.30	-90.6%	COM	65487U108
—	NUVATION BIO INC	124,119 (-6.9%)	$41 (+52.0%)	0.0%	$0.28	—	*W EXP 02/10/202	67080N119

Unchanged Positions (4)

SEPN SEPTERNA INC 9.1%

Value ($000) $87,798 Shares 3,149,128 Est. Cost $22.17 Unrealized +7.7%

NGNE NEUROGENE INC 3.6%

Value ($000) $35,373 Shares 1,717,127 Est. Cost $20.31 Unrealized +22.6%

ABVX ABIVAX SA 1.0%

Value ($000) $10,174 Shares 75,442 Est. Cost $84.90 Unrealized —

AQST AQUESTIVE THERAPEUTICS INC 1.7%

Value ($000) $16,150 Shares 2,500,000 Est. Cost $4.32 Unrealized +44.1%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
SEPN	SEPTERNA INC	3,149,128	$87,798	9.1%	$22.17	+7.7%	COM	81734D104
NGNE	NEUROGENE INC	1,717,127	$35,373	3.6%	$20.31	+22.6%	COM	64135M105
ABVX	ABIVAX SA	75,442	$10,174	1.0%	$84.90	—	SPONSORED ADS	00370M103
AQST	AQUESTIVE THERAPEUTICS INC	2,500,000	$16,150	1.7%	$4.32	+44.1%	COM	03843E104