UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Samsara BioCapital, LLC's Holding History (CIK: 0001744967)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 736,047 Value ($000) $19,984 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 962,154 Value ($000) $18,098 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 1,443,231 Value ($000) $15,847 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 2,067,146 Value ($000) $12,651 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 2,217,146 Value ($000) $36,450 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	736,047	$19,984	$24.89	$18.05 - $33.00
Q3 2025	962,154	$18,098	$15.54	$10.54 - $21.03
Q2 2025	1,443,231	$15,847	$9.24	$5.14 - $12.10
Q1 2025	2,067,146	$12,651	$9.55	$6.12 - $18.95
Q4 2024	2,217,146	$36,450	$22.33	$14.97 - $29.46