Kynam Capital Management, LP Diversified Active

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
BEAM	BEAM THERAPEUTICS INC	937,000	$25,974	1.7%	$25.65	-0.5%	CALL	07373V105
BHVN	BIOHAVEN LTD	702,884	$7,936	0.5%	$12.39	0.0%	COM	G1110E107
STRO	SUTRO BIOPHARMA INC	479,590	$5,549	0.4%	$9.49	0.0%	COM SHS	869367201
OMER	OMEROS CORP	200,000	$3,436	0.2%	—	—	PUT	682143102
EVMN	EVOMMUNE INC	185,482	$3,175	0.2%	$18.78	0.0%	COM SHS	30054Y107
ALEC	ALECTOR INC	2,000,000	$3,120	0.2%	$1.77	0.0%	COM	014442107
PRLD	PRELUDE THERAPEUTICS INC	788,867	$2,288	0.1%	$1.69	0.0%	COM	74065P101

Increased Positions (4)

CTMX CYTOMX THERAPEUTICS INC 2.4%

Value ($000) $38,195 (+228.4%) Shares 8,966,077 (+145.9%) Est. Cost $3.02 Unrealized +26.0%

KALV KALVISTA PHARMACEUTICALS INC 1.9%

Value ($000) $29,247 (+296.1%) Shares 1,810,954 (+198.8%) Est. Cost $13.44 Unrealized -1.4%

CGEM CULLINAN THERAPEUTICS INC 2.1%

Value ($000) $32,231 (+136.1%) Shares 3,114,132 (+35.3%) Est. Cost $11.02 Unrealized -18.1%

APLS APELLIS PHARMACEUTICALS INC 1.5%

Value ($000) $22,824 (+24.7%) Shares 908,607 (+12.4%) Est. Cost $23.34 Unrealized +0.5%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
CTMX	CYTOMX THERAPEUTICS INC	8,966,077 (+145.9%)	$38,195 (+228.4%)	2.4%	$3.02	+26.0%	COM	23284F105
KALV	KALVISTA PHARMACEUTICALS INC	1,810,954 (+198.8%)	$29,247 (+296.1%)	1.9%	$13.44	-1.4%	COM	483497103
CGEM	CULLINAN THERAPEUTICS INC	3,114,132 (+35.3%)	$32,231 (+136.1%)	2.1%	$11.02	-18.1%	COM	230031106
APLS	APELLIS PHARMACEUTICALS INC	908,607 (+12.4%)	$22,824 (+24.7%)	1.5%	$23.34	+0.5%	COM	03753U106

Exited Positions (5)

UTHR UNITED THERAPEUTICS CORP DEL 1.3%

Value ($000) $20,010 Shares 67,588 Est. Cost $336.31 Unrealized +38.5%

IRWD IRONWOOD PHARMACEUTICALS INC 0.5%

Value ($000) $7,162 Shares 5,466,825 Est. Cost $6.46 Unrealized -59.8%

URGN UROGEN PHARMA LTD 0.4%

Value ($000) $6,936 Shares 282,412 Est. Cost $9.64 Unrealized +125.1%

— SUTRO BIOPHARMA INC 0.3%

Value ($000) $4,419 Shares 5,088,099 Est. Cost $2.71 Unrealized —

EWTX EDGEWISE THERAPEUTICS INC 0.3%

Value ($000) $4,120 Shares 253,979 Est. Cost $14.42 Unrealized +39.2%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
UTHR	UNITED THERAPEUTICS CORP DEL	67,588	$20,010	1.3%	$336.31	+38.5%	—	91307C102
IRWD	IRONWOOD PHARMACEUTICALS INC	5,466,825	$7,162	0.5%	$6.46	-59.8%	—	46333X108
URGN	UROGEN PHARMA LTD	282,412	$6,936	0.4%	$9.64	+125.1%	—	M96088105
—	SUTRO BIOPHARMA INC	5,088,099	$4,419	0.3%	$2.71	—	—	869367102
EWTX	EDGEWISE THERAPEUTICS INC	253,979	$4,120	0.3%	$14.42	+39.2%	—	28036F105

Decreased Positions (22)

COGT COGENT BIOSCIENCES INC 14.0%

Value ($000) $218,989 (+93.4%) Shares 6,165,223 (-21.8%) Est. Cost $7.97 Unrealized +252.9%

VERA VERA THERAPEUTICS INC 11.1%

Value ($000) $173,850 (+48.5%) Shares 3,433,051 (-14.8%) Est. Cost $21.50 Unrealized +65.2%

VRDN VIRIDIAN THERAPEUTICS INC 2.9%

Value ($000) $45,763 (-52.1%) Shares 1,470,541 (-66.8%) Est. Cost $16.74 Unrealized +63.9%

CGON CG ONCOLOGY INC 2.5%

Value ($000) $39,271 (-51.4%) Shares 945,830 (-52.8%) Est. Cost $34.56 Unrealized +19.7%

SNDX SYNDAX PHARMACEUTICALS INC 10.8%

Value ($000) $169,151 (+29.0%) Shares 8,050,959 (-5.5%) Est. Cost $17.75 Unrealized -1.7%

PCVX VAXCYTE INC 8.6%

Value ($000) $134,837 (+21.9%) Shares 2,922,335 (-4.9%) Est. Cost $77.50 Unrealized -42.3%

ENGN ENGENE HOLDINGS INC 0.9%

Value ($000) $13,481 (-60.5%) Shares 1,492,898 (-70.1%) Est. Cost $7.65 Unrealized +4.7%

NRIX NURIX THERAPEUTICS INC 2.4%

Value ($000) $37,378 (+86.5%) Shares 1,970,357 (-9.1%) Est. Cost $12.80 Unrealized +12.3%

TYRA TYRA BIOSCIENCES INC 2.6%

Value ($000) $41,130 (+26.2%) Shares 1,564,492 (-32.9%) Est. Cost $13.36 Unrealized +37.5%

IMCR IMMUNOCORE HLDGS PLC 1.9%

Value ($000) $29,728 (-18.9%) Shares 856,462 (-15.1%) Est. Cost $29.77 Unrealized —

BEAM BEAM THERAPEUTICS INC 4.3%

Value ($000) $67,643 (+10.7%) Shares 2,440,214 (-3.1%) Est. Cost $25.65 Unrealized -0.5%

MBX MBX BIOSCIENCES INC 1.9%

Value ($000) $29,484 (-15.8%) Shares 934,799 (-53.3%) Est. Cost $13.37 Unrealized +81.5%

AMRN AMARIN CORP PLC 0.3%

Value ($000) $5,432 (-42.4%) Shares 389,273 (-32.4%) Est. Cost $16.22 Unrealized —

CLDX CELLDEX THERAPEUTICS INC NEW 10.3%

Value ($000) $161,417 (+2.3%) Shares 5,943,180 (-2.6%) Est. Cost $29.50 Unrealized -10.7%

WVE WAVE LIFE SCIENCES LTD 2.4%

Value ($000) $36,875 (+10.5%) Shares 2,169,105 (-52.4%) Est. Cost $4.64 Unrealized +119.0%

CRBU CARIBOU BIOSCIENCES INC 0.3%

Value ($000) $3,980 (-44.3%) Shares 2,503,302 (-18.4%) Est. Cost $3.41 Unrealized -38.5%

RLAY RELAY THERAPEUTICS INC 0.8%

Value ($000) $12,049 (-20.0%) Shares 1,424,259 (-50.7%) Est. Cost $4.42 Unrealized +61.6%

TVTX TRAVERE THERAPEUTICS INC 1.3%

Value ($000) $19,788 (-12.8%) Shares 517,884 (-45.5%) Est. Cost $15.29 Unrealized +112.6%

PHVS PHARVARIS N V 1.1%

Value ($000) $17,771 (+5.5%) Shares 640,395 (-5.1%) Est. Cost $22.18 Unrealized +8.6%

DSGN DESIGN THERAPEUTICS INC 0.5%

Value ($000) $7,360 (-5.1%) Shares 784,606 (-23.8%) Est. Cost $4.65 Unrealized +68.6%

PRQR PROQR THRAPEUTICS N V 0.2%

Value ($000) $3,164 (-9.9%) Shares 1,566,317 (-5.0%) Est. Cost $3.18 Unrealized -26.4%

— DYNAVAX TECHNOLOGIES CORP 1.4%

Value ($000) $21,157 (-0.7%) Shares 1,375,632 (-35.9%) Est. Cost $12.15 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
COGT	COGENT BIOSCIENCES INC	6,165,223 (-21.8%)	$218,989 (+93.4%)	14.0%	$7.97	+252.9%	COM	19240Q201
VERA	VERA THERAPEUTICS INC	3,433,051 (-14.8%)	$173,850 (+48.5%)	11.1%	$21.50	+65.2%	CL A	92337R101
VRDN	VIRIDIAN THERAPEUTICS INC	1,470,541 (-66.8%)	$45,763 (-52.1%)	2.9%	$16.74	+63.9%	COM	92790C104
CGON	CG ONCOLOGY INC	945,830 (-52.8%)	$39,271 (-51.4%)	2.5%	$34.56	+19.7%	COM	156944100
SNDX	SYNDAX PHARMACEUTICALS INC	8,050,959 (-5.5%)	$169,151 (+29.0%)	10.8%	$17.75	-1.7%	COM	87164F105
PCVX	VAXCYTE INC	2,922,335 (-4.9%)	$134,837 (+21.9%)	8.6%	$77.50	-42.3%	COM	92243G108
ENGN	ENGENE HOLDINGS INC	1,492,898 (-70.1%)	$13,481 (-60.5%)	0.9%	$7.65	+4.7%	COM	29286M105
NRIX	NURIX THERAPEUTICS INC	1,970,357 (-9.1%)	$37,378 (+86.5%)	2.4%	$12.80	+12.3%	COM	67080M103
TYRA	TYRA BIOSCIENCES INC	1,564,492 (-32.9%)	$41,130 (+26.2%)	2.6%	$13.36	+37.5%	COM	90240B106
IMCR	IMMUNOCORE HLDGS PLC	856,462 (-15.1%)	$29,728 (-18.9%)	1.9%	$29.77	—	ADS	45258D105
BEAM	BEAM THERAPEUTICS INC	2,440,214 (-3.1%)	$67,643 (+10.7%)	4.3%	$25.65	-0.5%	COM	07373V105
MBX	MBX BIOSCIENCES INC	934,799 (-53.3%)	$29,484 (-15.8%)	1.9%	$13.37	+81.5%	COM	55287L101
AMRN	AMARIN CORP PLC	389,273 (-32.4%)	$5,432 (-42.4%)	0.3%	$16.22	—	SPONSORED ADR	023111404
CLDX	CELLDEX THERAPEUTICS INC NEW	5,943,180 (-2.6%)	$161,417 (+2.3%)	10.3%	$29.50	-10.7%	COM NEW	15117B202
WVE	WAVE LIFE SCIENCES LTD	2,169,105 (-52.4%)	$36,875 (+10.5%)	2.4%	$4.64	+119.0%	SHS	Y95308105
CRBU	CARIBOU BIOSCIENCES INC	2,503,302 (-18.4%)	$3,980 (-44.3%)	0.3%	$3.41	-38.5%	COM	142038108
RLAY	RELAY THERAPEUTICS INC	1,424,259 (-50.7%)	$12,049 (-20.0%)	0.8%	$4.42	+61.6%	COM	75943R102
TVTX	TRAVERE THERAPEUTICS INC	517,884 (-45.5%)	$19,788 (-12.8%)	1.3%	$15.29	+112.6%	COM	89422G107
PHVS	PHARVARIS N V	640,395 (-5.1%)	$17,771 (+5.5%)	1.1%	$22.18	+8.6%	COM	N69605108
DSGN	DESIGN THERAPEUTICS INC	784,606 (-23.8%)	$7,360 (-5.1%)	0.5%	$4.65	+68.6%	COM	25056L103
PRQR	PROQR THRAPEUTICS N V	1,566,317 (-5.0%)	$3,164 (-9.9%)	0.2%	$3.18	-26.4%	SHS EURO	N71542109
—	DYNAVAX TECHNOLOGIES CORP	1,375,632 (-35.9%)	$21,157 (-0.7%)	1.4%	$12.15	—	COM NEW	268158201

Unchanged Positions (4)

BNR BURNING ROCK BIOTECH LTD 1.3%

Value ($000) $20,047 Shares 994,883 Est. Cost $6.40 Unrealized —

CLYM CLIMB BIO INC 0.3%

Value ($000) $4,113 Shares 1,028,341 Est. Cost $2.66 Unrealized -9.9%

BCRX BIOCRYST PHARMACEUTICALS INC 4.7%

Value ($000) $73,059 Shares 9,366,526 Est. Cost $6.82 Unrealized +5.9%

GERN GERON CORP 0.3%

Value ($000) $4,562 Shares 3,456,318 Est. Cost $2.44 Unrealized -48.5%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
BNR	BURNING ROCK BIOTECH LTD	994,883	$20,047	1.3%	$6.40	—	SPONSORED ADS	12233L206
CLYM	CLIMB BIO INC	1,028,341	$4,113	0.3%	$2.66	-9.9%	COM	28658R106
BCRX	BIOCRYST PHARMACEUTICALS INC	9,366,526	$73,059	4.7%	$6.82	+5.9%	COM	09058V103
GERN	GERON CORP	3,456,318	$4,562	0.3%	$2.44	-48.5%	COM	374163103