| QVT Financial LP | 4,615,709 | $10,612 |
| ORBIMED ADVISORS LLC | 4,166,000 | $10,082 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,700,000 | $8,954 |
| ACUTA CAPITAL PARTNERS, LLC | 3,410,402 | $8,253 |
| Avoro Capital Advisors LLC | 2,849,402 | $6,896 |
| KVP Capital Advisors, LP | 2,165,997 | $5,242 |
| Siren, L.L.C. | 2,082,000 | $5,038 |
| Yu Fan | 2,070,000 | $5,009 |
| VANGUARD GROUP INC | 1,590,117 | $3,848 |
| STEMPOINT CAPITAL LP | 1,458,807 | $3,530 |
| ACORN CAPITAL ADVISORS, LLC | 1,139,363 | $2,757 |
| Ally Bridge Group (NY) LLC | 817,939 | $1,979 |
| RENAISSANCE TECHNOLOGIES LLC | 440,722 | $1,067 |
| GEODE CAPITAL MANAGEMENT, LLC | 425,440 | $1,030 |
| TWO SIGMA INVESTMENTS, LP | 309,865 | $750 |
| BlackRock, Inc. | 299,011 | $724 |
| Eversept Partners, LP | 260,259 | $630 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 215,284 | $521 |
| STATE STREET CORP | 145,537 | $352 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 110,083 | $266 |
| NORTHERN TRUST CORP | 103,452 | $250 |
| CITADEL ADVISORS LLC | 98,950 | $239 |
| ADAR1 Capital Management, LLC | 77,593 | $188 |
| Qube Research & Technologies Ltd | 72,348 | $175 |
| JANE STREET GROUP, LLC | 69,931 | $169 |
| MARSHALL WACE, LLP | 67,959 | $164 |
| TWO SIGMA ADVISERS, LP | 42,400 | $103 |
| UBS Group AG | 29,844 | $72 |
| DIMENSIONAL FUND ADVISORS LP | 28,641 | $69 |
| ABG Innovation Capital Partners III GP Ltd | 26,666 | $65 |
| ACADIAN ASSET MANAGEMENT LLC | 24,634 | $0 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 18,796 | $45 |
| XTX Topco Ltd | 15,704 | $38 |
| Quadrature Capital Ltd | 11,447 | $28 |
| MORGAN STANLEY | 6,748 | $16 |
| US BANCORP \DE\ | 3,333 | $8 |
| OSAIC HOLDINGS, INC. | 3,070 | $7 |
| BARTLETT & CO. WEALTH MANAGEMENT LLC | 1,333 | $3 |
| Torren Management, LLC | 1,254 | $3 |
| BANK OF AMERICA CORP /DE/ | 411 | $1 |
| Russell Investments Group, Ltd. | 386 | $1 |
| TD Waterhouse Canada Inc. | 232 | $1 |
| BNP PARIBAS ARBITRAGE, SA | 160 | $0 |
| JPMORGAN CHASE & CO | 121 | $0 |
| GROUP ONE TRADING, L.P. | 100 | $0 |
| CWM, LLC | 25 | $0 |
| SBI Securities Co., Ltd. | 19 | $0 |
| Parallel Advisors, LLC | 8 | $0 |