SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

RENAISSANCE TECHNOLOGIES LLC's Holding History (CIK: 0001037389)

Note: Option positions (PUT/CALL) are excluded.

Q2 2025

Shares 30,936 Value ($000) $463 Avg Close $14.80 Range $10.91 - $19.20

Q1 2024

Shares 49,468 Value ($000) $2 Avg Close $28.97 Range $18.54 - $47.97

Q4 2023

Shares 48,536 Value ($000) $1 Avg Close $13.78 Range $8.43 - $22.66

Q3 2023

Shares 23,229 Value ($000) $0 Avg Close $13.22 Range $9.53 - $18.00

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2025	30,936	$463	$14.80	$10.91 - $19.20
Q1 2024	49,468	$2	$28.97	$18.54 - $47.97
Q4 2023	48,536	$1	$13.78	$8.43 - $22.66
Q3 2023	23,229	$0	$13.22	$9.53 - $18.00