SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

RHUMBLINE ADVISERS's Holding History (CIK: 0001115418)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 82,956 Value ($000) $2,718 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 70,914 Value ($000) $1,189 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 73,168 Value ($000) $1,095 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 56,023 Value ($000) $904 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 57,657 Value ($000) $1,342 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 53,935 Value ($000) $1,586 Avg Close $27.85 Range $23.00 - $32.41

Q2 2024

Shares 51,896 Value ($000) $1,220 Avg Close $33.73 Range $22.19 - $40.84

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	82,956	$2,718	$26.13	$15.86 - $35.31
Q3 2025	70,914	$1,189	$16.31	$14.00 - $18.30
Q2 2025	73,168	$1,095	$14.80	$10.91 - $19.20
Q1 2025	56,023	$904	$20.81	$16.13 - $26.01
Q4 2024	57,657	$1,342	$29.32	$22.37 - $40.26
Q3 2024	53,935	$1,586	$27.85	$23.00 - $32.41
Q2 2024	51,896	$1,220	$33.73	$22.19 - $40.84