SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Rafferty Asset Management, LLC's Holding History (CIK: 0001389426)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 53,410 Value ($000) $1,750 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 59,667 Value ($000) $1,000 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 50,957 Value ($000) $763 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 70,323 Value ($000) $1,135 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 76,740 Value ($000) $1,787 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 70,586 Value ($000) $2,076 Avg Close $27.85 Range $23.00 - $32.41

Q2 2024

Shares 67,109 Value ($000) $1,578 Avg Close $33.73 Range $22.19 - $40.84

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	53,410	$1,750	$26.13	$15.86 - $35.31
Q3 2025	59,667	$1,000	$16.31	$14.00 - $18.30
Q2 2025	50,957	$763	$14.80	$10.91 - $19.20
Q1 2025	70,323	$1,135	$20.81	$16.13 - $26.01
Q4 2024	76,740	$1,787	$29.32	$22.37 - $40.26
Q3 2024	70,586	$2,076	$27.85	$23.00 - $32.41
Q2 2024	67,109	$1,578	$33.73	$22.19 - $40.84